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Nω-Propyl-L-arginine hydrochloride

CAS# 137361-05-8

Nω-Propyl-L-arginine hydrochloride

Catalog No. BCC6965----Order now to get a substantial discount!

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Chemical structure

Nω-Propyl-L-arginine hydrochloride

3D structure

Chemical Properties of Nω-Propyl-L-arginine hydrochloride

Cas No. 137361-05-8 SDF Download SDF
PubChem ID 447180 Appearance Powder
Formula C9H20N4O2 M.Wt 216.3
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in water and to 100 mM in DMSO
Chemical Name (2S)-2-amino-5-[(N'-propylcarbamimidoyl)amino]pentanoic acid
SMILES CCCN=C(N)NCCCC(C(=O)O)N
Standard InChIKey AOMXURITGZJPKB-ZETCQYMHSA-N
Standard InChI InChI=1S/C9H20N4O2/c1-2-5-12-9(11)13-6-3-4-7(10)8(14)15/h7H,2-6,10H2,1H3,(H,14,15)(H3,11,12,13)/t7-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Nω-Propyl-L-arginine hydrochloride

DescriptionHighly selective and potent inhibitor of nNOS (Ki = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo.

Nω-Propyl-L-arginine hydrochloride Dilution Calculator

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Nω-Propyl-L-arginine hydrochloride Molarity Calculator

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Preparing Stock Solutions of Nω-Propyl-L-arginine hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.6232 mL 23.116 mL 46.2321 mL 92.4642 mL 115.5802 mL
5 mM 0.9246 mL 4.6232 mL 9.2464 mL 18.4928 mL 23.116 mL
10 mM 0.4623 mL 2.3116 mL 4.6232 mL 9.2464 mL 11.558 mL
50 mM 0.0925 mL 0.4623 mL 0.9246 mL 1.8493 mL 2.3116 mL
100 mM 0.0462 mL 0.2312 mL 0.4623 mL 0.9246 mL 1.1558 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Nω-Propyl-L-arginine hydrochloride

The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney.[Pubmed:11404282]

Am J Physiol Regul Integr Comp Physiol. 2001 Jul;281(1):R91-7.

The role of nitric oxide (NO) produced by NO synthase 1 (NOS1) in the renal vasculature remains undetermined. In the present study, we investigated the influence of systemic inhibition of NOS1 by intravenous administration of N(omega)-propyl-L-arginine (L-NPA; 1 mg. kg(-1). h(-1)) and N(5)-(1-imino-3-butenyl)-L-ornithine (v-NIO; 1 mg. kg(-1). h(-1)), highly selective NOS1 inhibitors, on renal cortical and medullary blood flow and interstitial NO concentration in Sprague-Dawley rats. Arterial blood pressure was significantly decreased by administration of both NOS1-selective inhibitors (-11 +/- 1 mmHg with L-NPA and -7 +/- 1 mmHg with v-NIO; n = 9/group). Laser-Doppler flowmetry experiments demonstrated that blood flow in the renal cortex and medulla was not significantly altered following administration of either NOS1-selective inhibitor. In contrast, the renal interstitial level of NO assessed by an in vivo microdialysis oxyhemoglobin-trapping technique was significantly decreased in both the renal cortex (by 36-42%) and medulla (by 32-40%) following administration of L-NPA (n = 8) or v-NIO (n = 8). Subsequent infusion of the nonspecific NOS inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME; 50 mg. kg(-1). h(-1)) to rats pretreated with either of the NOS1-selective inhibitors significantly increased mean arterial pressure by 38-45 mmHg and significantly decreased cortical (25-29%) and medullary (37-43%) blood flow. In addition, L-NAME further decreased NO in the renal cortex (73-77%) and medulla (62-71%). To determine if a 40% decrease in NO could alter renal blood flow, a lower dose of L-NAME (5 mg. kg(-1). h(-1); n = 8) was administered to a separate group of rats. The low dose of L-NAME reduced interstitial NO (cortex 39%, medulla 38%) and significantly decreased blood flow (cortex 23-24%, medulla 31-33%). These results suggest that NOS1 does not regulate basal blood flow in the renal cortex or medulla, despite the observation that a considerable portion of NO in the renal interstitial space appears to be produced by NOS1.

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