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Pasiniazid

CAS# 2066-89-9

Pasiniazid

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Chemical structure

Pasiniazid

3D structure

Chemical Properties of Pasiniazid

Cas No. 2066-89-9 SDF Download SDF
PubChem ID 16367 Appearance Powder
Formula C13H14N4O4 M.Wt 290.27
Type of Compound N/A Storage Desiccate at -20°C
Synonyms Paraniazide; Pasiniazide; Isonicotinic acid hydrazide p-aminosalicylate
Solubility DMSO : ≥ 160 mg/mL (551.21 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name 4-amino-2-hydroxybenzoic acid;pyridine-4-carbohydrazide
SMILES C1=CC(=C(C=C1N)O)C(=O)O.C1=CN=CC=C1C(=O)NN
Standard InChIKey RKPHTRVPGYGVQD-UHFFFAOYSA-N
Standard InChI InChI=1S/C7H7NO3.C6H7N3O/c8-4-1-2-5(7(10)11)6(9)3-4;7-9-6(10)5-1-3-8-4-2-5/h1-3,9H,8H2,(H,10,11);1-4H,7H2,(H,9,10)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Pasiniazid

DescriptionPasiniazid is an anti-TB and anti-leprosy drug, used to treat various types of TB and leprosy.

Pasiniazid Dilution Calculator

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Pasiniazid Molarity Calculator

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Preparing Stock Solutions of Pasiniazid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4451 mL 17.2253 mL 34.4507 mL 68.9014 mL 86.1267 mL
5 mM 0.689 mL 3.4451 mL 6.8901 mL 13.7803 mL 17.2253 mL
10 mM 0.3445 mL 1.7225 mL 3.4451 mL 6.8901 mL 8.6127 mL
50 mM 0.0689 mL 0.3445 mL 0.689 mL 1.378 mL 1.7225 mL
100 mM 0.0345 mL 0.1723 mL 0.3445 mL 0.689 mL 0.8613 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Pasiniazid

On-column amperometric detection of ofloxacin and pasiniazid in urine by capillary electrophoresis with an improved fractured joint and small detection cell.[Pubmed:11340975]

Analyst. 2001 Apr;126(4):441-5.

An improved high-voltage electric field isolating joint and small detection cell have been carefully designed and fabricated. The joint possesses short steady time, high electric conductance efficiency and high performance. The cell is convenient to install and remove the capillaries with and without the joint, as well as to fix, adjust and insert the microelectrode into the detection capillary. Using the joint and the cell, an analytical method for determination of ofloxacin (Oflx) and Pasiniazid (Ipa) in urine by capillary electrophoresis with on-column amperometric detection was developed. The calibration lines were linear in the range of 10-100 mg l-1 of Oflx and 1.0-50 mg l-1 of Ipa, respectively. The detection limits were 8.5 mg l-1 of Oflx and 0.80 mg l-1 of Ipa. Their recovery ranged from 101 to 104%. The accuracy and intra-day and inter-day reproducibility of Oflx and Ipa were determined with satisfactory results. This method was successfully used for determining Oflx and Ipa in human urine.

Description

Pasiniazid is an anti-TB and anti-leprosy drug, used to treat various types of TB and leprosy.

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