TB 21007

CAS# 207306-50-1

TB 21007

Catalog No. BCC7510----Order now to get a substantial discount!

Product Name & Size Price Stock
TB 21007: 5mg $104 In Stock
TB 21007: 10mg Please Inquire In Stock
TB 21007: 20mg Please Inquire Please Inquire
TB 21007: 50mg Please Inquire Please Inquire
TB 21007: 100mg Please Inquire Please Inquire
TB 21007: 200mg Please Inquire Please Inquire
TB 21007: 500mg Please Inquire Please Inquire
TB 21007: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of TB 21007

Number of papers citing our products

Chemical structure

TB 21007

3D structure

Chemical Properties of TB 21007

Cas No. 207306-50-1 SDF Download SDF
PubChem ID 6918633 Appearance Powder
Formula C15H17NO2S3 M.Wt 339.5
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO and to 25 mM in ethanol
Chemical Name 3-(2-hydroxyethylsulfanyl)-6,6-dimethyl-1-(1,3-thiazol-2-yl)-5,7-dihydro-2-benzothiophen-4-one
SMILES CC1(CC2=C(SC(=C2C(=O)C1)SCCO)C3=NC=CS3)C
Standard InChIKey QILRYFCEXLFIDS-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of TB 21007

DescriptionGABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.

TB 21007 Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

TB 21007 Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of TB 21007

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9455 mL 14.7275 mL 29.4551 mL 58.9102 mL 73.6377 mL
5 mM 0.5891 mL 2.9455 mL 5.891 mL 11.782 mL 14.7275 mL
10 mM 0.2946 mL 1.4728 mL 2.9455 mL 5.891 mL 7.3638 mL
50 mM 0.0589 mL 0.2946 mL 0.5891 mL 1.1782 mL 1.4728 mL
100 mM 0.0295 mL 0.1473 mL 0.2946 mL 0.5891 mL 0.7364 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on TB 21007

Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.[Pubmed:12747794]

J Med Chem. 2003 May 22;46(11):2227-40.

In pursuit of a GABA(A) alpha5-subtype-selective inverse agonist to enhance cognition, a series of 6,7-dihydro-2-benzothiophen-4(5H)-ones has been identified as a novel class of GABA(A) receptor ligands. These thiophenes have higher binding affinity for the GABA(A) alpha5 receptor subtype compared to the GABA(A) alpha1, alpha2, and alpha3 subtypes, and several analogues exhibit high GABA(A) alpha5 receptor inverse agonism. 6,6-Dimethyl-3-(2-hydroxyethyl)thio-1-(thiazol-2-yl)-6,7-dihydro-2-benzothiophen- 4(5H)-one (43) has been identified as a full inverse agonist at the GABA(A) alpha5 receptor and is functionally selective over the other major GABA(A) receptor subtypes. 43 readily penetrates into the CNS to give selective occupancy of GABA(A) alpha5 receptors. In addition, 43 enhances cognitive performance in rats in the delayed 'matching-to-place' Morris water maze test-a hippocampal-dependent memory task-without the convulsant or proconvulsant activity associated with nonselective, GABA(A) receptor inverse agonists.

Keywords:

TB 21007,207306-50-1,Natural Products,GABA Receptor, buy TB 21007 , TB 21007 supplier , purchase TB 21007 , TB 21007 cost , TB 21007 manufacturer , order TB 21007 , high purity TB 21007

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: