Home >> Research Area >>GPCR/G protein>>NK3 Receptor>> SSR 146977 hydrochloride

SSR 146977 hydrochloride

Potent and selective NK3 antagonist CAS# 264618-38-4

SSR 146977 hydrochloride

Catalog No. BCC7635----Order now to get a substantial discount!

Product Name & Size Price Stock
SSR 146977 hydrochloride: 5mg $138 In Stock
SSR 146977 hydrochloride: 10mg Please Inquire In Stock
SSR 146977 hydrochloride: 20mg Please Inquire Please Inquire
SSR 146977 hydrochloride: 50mg Please Inquire Please Inquire
SSR 146977 hydrochloride: 100mg Please Inquire Please Inquire
SSR 146977 hydrochloride: 200mg Please Inquire Please Inquire
SSR 146977 hydrochloride: 500mg Please Inquire Please Inquire
SSR 146977 hydrochloride: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of SSR 146977 hydrochloride

Number of papers citing our products

Chemical structure

SSR 146977 hydrochloride

3D structure

Chemical Properties of SSR 146977 hydrochloride

Cas No. 264618-38-4 SDF Download SDF
PubChem ID 90488827 Appearance Powder
Formula C35H43Cl3N4O2 M.Wt 658.11
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO and to 100 mM in ethanol
Chemical Name 3-[1-[3-[(3R)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl]-4-phenylpiperidin-4-yl]-1,1-dimethylurea;hydrochloride
SMILES CN(C)C(=O)NC1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5.Cl
Standard InChIKey HYPKKQPFHSNZBY-GXUZKUJRSA-N
Standard InChI InChI=1S/C35H42Cl2N4O2.ClH/c1-39(2)33(43)38-35(28-13-7-4-8-14-28)19-23-40(24-20-35)21-9-17-34(29-15-16-30(36)31(37)25-29)18-10-22-41(26-34)32(42)27-11-5-3-6-12-27;/h3-8,11-16,25H,9-10,17-24,26H2,1-2H3,(H,38,43);1H/t34-;/m0./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of SSR 146977 hydrochloride

DescriptionPotent and selective NK3 receptor antagonist (Ki values are 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor respectively). Also inhibits senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC50 = 10 nM).

SSR 146977 hydrochloride Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

SSR 146977 hydrochloride Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of SSR 146977 hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5195 mL 7.5975 mL 15.195 mL 30.3901 mL 37.9876 mL
5 mM 0.3039 mL 1.5195 mL 3.039 mL 6.078 mL 7.5975 mL
10 mM 0.152 mL 0.7598 mL 1.5195 mL 3.039 mL 3.7988 mL
50 mM 0.0304 mL 0.152 mL 0.3039 mL 0.6078 mL 0.7598 mL
100 mM 0.0152 mL 0.076 mL 0.152 mL 0.3039 mL 0.3799 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on SSR 146977 hydrochloride

Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist.[Pubmed:12056557]

Can J Physiol Pharmacol. 2002 May;80(5):482-8.

SSR 146977 is a potent and selective antagonist of the tachykinin NK3 receptor. In Chinese hamster ovary cells expressing the human tachykinin NK3 receptor, SSR 146977 inhibited the binding of radioactive neurokinin B to NK3 receptors (Ki = 0.26 nM), senktide (10 nM) induced inositol monophosphate formation (IC50 = 7.8-13 nM), and intracellular calcium mobilization (IC50 = 10 nM). It antagonized [MePhe7]neurokinin B induced contractions of guinea pig ileum (pA2 = 9.07). Senktide (30 nM) induced firing rate increase of noradrenergic neurons in the guinea pig locus coeruleus and dopaminergic neurons in the guinea pig substantia nigra was also blocked by SSR 146977 (50 and 100 nM, respectively). In vivo, in the respiratory system, SSR 146977 inhibited bronchial hyperresponsiveness to acetylcholine, bronchial microvascular permeability hypersensitivity to histamine (doses of 0.1-1 mg/kg i.p.), and cough (doses of 0.03-1 mg/kg i.p.) provoked by citric acid in guinea pigs. In the central nervous system, SSR 146977 inhibited turning behaviour (ID50 = 0.2 mg/kg i.p. and 0.4 mg/kg p.o.) and prevented the decrease of locomotor activity (10 and 30 mg/kg i.p) mediated by the stimulation of NK3 receptors in gerbils. In guinea pigs, SSR 146977 antagonized senktide-induced acetylcholine release in the hippocampus (0.3 and 1 mg/kg i.p) and norepinephrine release in the prefrontal cortex (0.3 mg/kg i.p.). It also prevented haloperidol-induced increase of the number of spontaneously active dopamine A10 neurons (1 and 3 mg/kg i.p.).

Keywords:

SSR 146977 hydrochloride,264618-38-4,Natural Products,NK3 Receptor, buy SSR 146977 hydrochloride , SSR 146977 hydrochloride supplier , purchase SSR 146977 hydrochloride , SSR 146977 hydrochloride cost , SSR 146977 hydrochloride manufacturer , order SSR 146977 hydrochloride , high purity SSR 146977 hydrochloride

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: