SUN-B 8155

Non-peptide calcitonin (CT) receptor agonist CAS# 345893-91-6

SUN-B 8155

Catalog No. BCC7405----Order now to get a substantial discount!

Product Name & Size Price Stock
SUN-B 8155: 5mg $92 In Stock
SUN-B 8155: 10mg Please Inquire In Stock
SUN-B 8155: 20mg Please Inquire Please Inquire
SUN-B 8155: 50mg Please Inquire Please Inquire
SUN-B 8155: 100mg Please Inquire Please Inquire
SUN-B 8155: 200mg Please Inquire Please Inquire
SUN-B 8155: 500mg Please Inquire Please Inquire
SUN-B 8155: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of SUN-B 8155

Number of papers citing our products

Chemical structure

SUN-B 8155

3D structure

Chemical Properties of SUN-B 8155

Cas No. 345893-91-6 SDF Download SDF
PubChem ID 16079007 Appearance Powder
Formula C14H15N3O3 M.Wt 273.29
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO
Chemical Name (3Z)-3-[1-(2-aminoanilino)ethylidene]-1-hydroxy-4-methylpyridine-2,6-dione
SMILES CC1=CC(=O)N(C(=O)C1=C(C)NC2=CC=CC=C2N)O
Standard InChIKey IMUCOECFKIWBSW-LCYFTJDESA-N
Standard InChI InChI=1S/C14H15N3O3/c1-8-7-12(18)17(20)14(19)13(8)9(2)16-11-6-4-3-5-10(11)15/h3-7,16,20H,15H2,1-2H3/b13-9-
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of SUN-B 8155

DescriptionNon-peptide calcitonin (CT) receptor agonist that fully stimulates cAMP production in CHO/hCTR cells (EC50 = 21 μM). Causes a significant reduction in serum calcium concentrations in vivo following i.p. administration.

SUN-B 8155 Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

SUN-B 8155 Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of SUN-B 8155

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6591 mL 18.2956 mL 36.5912 mL 73.1823 mL 91.4779 mL
5 mM 0.7318 mL 3.6591 mL 7.3182 mL 14.6365 mL 18.2956 mL
10 mM 0.3659 mL 1.8296 mL 3.6591 mL 7.3182 mL 9.1478 mL
50 mM 0.0732 mL 0.3659 mL 0.7318 mL 1.4636 mL 1.8296 mL
100 mM 0.0366 mL 0.183 mL 0.3659 mL 0.7318 mL 0.9148 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on SUN-B 8155

Discovery of a non-peptide small molecule that selectively mimics the biological actions of calcitonin.[Pubmed:11325540]

Biochim Biophys Acta. 2001 May 3;1526(2):183-90.

Calcitonin (CT), a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis. To discover non-peptide small molecules with biological actions similar to those of CT, a cell-based screening of an in-house chemical library was performed and a pyridone derivative (SUN B8155) was identified. Like CT, it elevated cyclic AMP (cAMP) levels in T47D and UMR106-06 cells which endogenously express human and rat CT receptor, respectively. SUN B8155 also stimulated cAMP formation in cells expressing recombinant human CT receptor, but not in those expressing human parathyroid hormone/parathyroid hormone-related peptide receptor. Accumulation of cAMP in T47D cells was blocked by a selective antagonist of CT receptor, salmon CT(8-32), whereas SUN B8155 did not displace the specific binding of [(125)I]CT to the receptor. Our results suggested that the compound selectively interacts with the CT receptor by a mechanism similar to but probably different from that of CT itself. In rats, intraperitoneal administration of SUN B8155 significantly lowered serum calcium levels, like CT. Our results demonstrate, for the first time, that the biological activities of the newly identified small molecule can mimic that of CT, acting via the CT receptor.

Keywords:

SUN-B 8155,345893-91-6,Natural Products,Calcitonin and Related Receptors, buy SUN-B 8155 , SUN-B 8155 supplier , purchase SUN-B 8155 , SUN-B 8155 cost , SUN-B 8155 manufacturer , order SUN-B 8155 , high purity SUN-B 8155

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: