Wilfornine A

CAS# 345954-00-9

Wilfornine A

Catalog No. BCN3099----Order now to get a substantial discount!

Product Name & Size Price Stock
Wilfornine A: 5mg $575 In Stock
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Quality Control of Wilfornine A

Number of papers citing our products

Chemical structure

Wilfornine A

3D structure

Chemical Properties of Wilfornine A

Cas No. 345954-00-9 SDF Download SDF
PubChem ID 44584747 Appearance Powder
Formula C45H51NO20 M.Wt 925.9
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1S,3R,15R,18S,19R,20R,21R,22S,23R,24R,25R,26S)-19,20,22,23,25-pentaacetyloxy-21-(acetyloxymethyl)-26-hydroxy-3,15,26-trimethyl-6,16-dioxo-2,5,17-trioxa-11-azapentacyclo[16.7.1.01,21.03,24.07,12]hexacosa-7(12),8,10-trien-15-yl] benzoate
SMILES CC(=O)OCC12C(C(C3C(C14C(C(C(C2OC(=O)C)OC(=O)C)OC(=O)C(CCC5=C(C=CC=N5)C(=O)OCC3(O4)C)(C)OC(=O)C6=CC=CC=C6)(C)O)OC(=O)C)OC(=O)C)OC(=O)C
Standard InChIKey YJDNHPICMWQYIV-VTPOCOLISA-N
Standard InChI InChI=1S/C45H51NO20/c1-22(47)57-21-44-36(62-26(5)51)32(59-23(2)48)31-34(61-25(4)50)45(44)43(9,56)35(33(60-24(3)49)37(44)63-27(6)52)64-40(55)41(7,65-38(53)28-14-11-10-12-15-28)18-17-30-29(16-13-19-46-30)39(54)58-20-42(31,8)66-45/h10-16,19,31-37,56H,17-18,20-21H2,1-9H3/t31-,32-,33+,34-,35+,36-,37+,41-,42+,43+,44-,45+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Wilfornine A

The roots of Tripterygium wilfordii Hook. f.

Biological Activity of Wilfornine A

DescriptionWilfornine A is a natural product from Schisandra sphenanthera.

Protocol of Wilfornine A

Kinase Assay

Immunosuppressive sesquiterpene alkaloids from Tripterygium wilfordii.[Pubmed: 11374948]

J Nat Prod. 2001 May;64(5):582-7.

Nine new sesquiterpene pyridine alkaloids [Wilfornine A (1), wilfornine B (2), wilfornine C (3), wilfornine D (4), wilfornine E (5), wilfornine F (8), and wilfornine G (9); wilfordinines I (6) and J (7)] and six known compounds (10-15) were isolated from a clinically used extract (T(II)) of Tripterygium wilfordii.
METHODS AND RESULTS:
The structures of 1-9 were elucidated by spectroscopic and chemical methods. The inhibitory effects on cytokine production of 1-3 and several related compounds were evaluated. Compounds 10 and 14 showed significant inhibitory effects on cytokine production.

Wilfornine A Dilution Calculator

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Wilfornine A Molarity Calculator

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Preparing Stock Solutions of Wilfornine A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.08 mL 5.4002 mL 10.8003 mL 21.6006 mL 27.0008 mL
5 mM 0.216 mL 1.08 mL 2.1601 mL 4.3201 mL 5.4002 mL
10 mM 0.108 mL 0.54 mL 1.08 mL 2.1601 mL 2.7001 mL
50 mM 0.0216 mL 0.108 mL 0.216 mL 0.432 mL 0.54 mL
100 mM 0.0108 mL 0.054 mL 0.108 mL 0.216 mL 0.27 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Wilfornine A

Immunosuppressive sesquiterpene alkaloids from Tripterygium wilfordii.[Pubmed:11374948]

J Nat Prod. 2001 May;64(5):582-7.

Nine new sesquiterpene pyridine alkaloids [wilfornines A (1), B (2), C (3), D (4), E (5), F (8), and G (9); wilfordinines I (6) and J (7)] and six known compounds (10-15) were isolated from a clinically used extract (T(II)) of Tripterygium wilfordii. The structures of 1-9 were elucidated by spectroscopic and chemical methods. The inhibitory effects on cytokine production of 1-3 and several related compounds were evaluated. Compounds 10 and 14 showed significant inhibitory effects on cytokine production.

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