Tokinolide B

CAS# 112966-16-2

Tokinolide B

Catalog No. BCN2753----Order now to get a substantial discount!

Product Name & Size Price Stock
Tokinolide B: 5mg $161 In Stock
Tokinolide B: 10mg Please Inquire In Stock
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Quality Control of Tokinolide B

Number of papers citing our products

Chemical structure

Tokinolide B

3D structure

Chemical Properties of Tokinolide B

Cas No. 112966-16-2 SDF Download SDF
PubChem ID 11090206 Appearance Powder
Formula C24H28O4 M.Wt 380.48
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1S,2Z,7R,8R,9S)-2-butylidene-8-propylspiro[3-oxatricyclo[5.2.2.01,5]undec-5-ene-9,3'-4,5-dihydro-2-benzofuran]-1',4-dione
SMILES CCCC=C1C23CCC(C=C2C(=O)O1)C(C34C5=C(C=CCC5)C(=O)O4)CCC
Standard InChIKey DZMFTLLDUYBHLI-MUSNRYMWSA-N
Standard InChI InChI=1S/C24H28O4/c1-3-5-11-20-23-13-12-15(14-19(23)22(26)27-20)17(8-4-2)24(23)18-10-7-6-9-16(18)21(25)28-24/h6,9,11,14-15,17H,3-5,7-8,10,12-13H2,1-2H3/b20-11-/t15-,17-,23+,24+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Tokinolide B

The roots of Angelica sinensis

Biological Activity of Tokinolide B

DescriptionTokinolide B may have sedative and spasmolytic properties.
In vitro

Phthalides and other constituents from Ligusticum porteri; sedative and spasmolytic activities of some natural products and derivatives.[Pubmed: 21797735 ]

Nat Prod Res. 2011 Aug;25(13):1234-42.


METHODS AND RESULTS:
The chemical constituents of the organic extracts from the rhizomes of Ligusticum porteri were isolated, characterised and identified as Z-ligustilide, Z-butylidenephthalide, diligustilide, Tokinolide B, riligustilide, senkyunolides F and I, ferulic acid, among other known compounds. The preparation of 4,5-dehydroTokinolide B from Tokinolide B is reported, and its structure confirmed by X-ray analysis. The sedative and spasmolytic activities of some of these natural products and derivatives were evaluated by applying them to in vivo and in vitro models.
CONCLUSIONS:
Several of these dimeric phthalides displayed sedative and spasmolytic properties that may correlate with some popular uses of L. porteri.

Protocol of Tokinolide B

Structure Identification
Zhongguo Zhong Yao Za Zhi. 2008 Oct;33(19):2196-201.

Study on biligustilides from Angelica sinensis.[Pubmed: 19166005]

To study the chemical constituents of Angelica sinensis.
METHODS AND RESULTS:
The constituents were separated by chromatographic methods, and their structures were identified on the basis of spectroscopic analysis. Eight compounds were isolated and identified as levistolide A (1), senkyunolide O (2), (3Z, 3Z')-6.8', 7.3'-diligustilide (3), Tokinolide B (4), isoTokinolide B (5), (3'Z)-(3R, 8S, 3a'R, 6'S)-3, 3a': 8, 6'-biligustilide (6), E, E'-3. 3', 8. 8'-diligustilide (7) and E, E'-3. 3', 8. 8'-isodiligustilide (8), which are all diligustilides.
CONCLUSIONS:
Compound 7 was obtained from the plant for the first time; compounds 6 and 8 are new compounds.

Tokinolide B Dilution Calculator

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Tokinolide B Molarity Calculator

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Preparing Stock Solutions of Tokinolide B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6283 mL 13.1413 mL 26.2826 mL 52.5652 mL 65.7065 mL
5 mM 0.5257 mL 2.6283 mL 5.2565 mL 10.513 mL 13.1413 mL
10 mM 0.2628 mL 1.3141 mL 2.6283 mL 5.2565 mL 6.5706 mL
50 mM 0.0526 mL 0.2628 mL 0.5257 mL 1.0513 mL 1.3141 mL
100 mM 0.0263 mL 0.1314 mL 0.2628 mL 0.5257 mL 0.6571 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Tokinolide B

[Study on biligustilides from Angelica sinensis].[Pubmed:19166005]

Zhongguo Zhong Yao Za Zhi. 2008 Oct;33(19):2196-201.

OBJECTIVE: To study the chemical constituents of Angelica sinensis. METHOD: The constituents were separated by chromatographic methods, and their structures were identified on the basis of spectroscopic analysis. RESULT: Eight compounds were isolated and identified as levistolide A (1), senkyunolide O (2), (3Z, 3Z')-6.8', 7.3'-diligustilide (3), Tokinolide B (4), isoTokinolide B (5), (3'Z)-(3R, 8S, 3a'R, 6'S)-3, 3a': 8, 6'-biligustilide (6), E, E'-3. 3', 8. 8'-diligustilide (7) and E, E'-3. 3', 8. 8'-isodiligustilide (8), which are all diligustilides. CONCLUSION: Compound 7 was obtained from the plant for the first time; compounds 6 and 8 are new compounds.

Phthalides and other constituents from Ligusticum porteri; sedative and spasmolytic activities of some natural products and derivatives.[Pubmed:21797735]

Nat Prod Res. 2011 Aug;25(13):1234-42.

The chemical constituents of the organic extracts from the rhizomes of Ligusticum porteri were isolated, characterised and identified as Z-ligustilide, Z-butylidenephthalide, diligustilide, Tokinolide B, riligustilide, senkyunolides F and I, ferulic acid, among other known compounds. The preparation of 4,5-dehydroTokinolide B from Tokinolide B is reported, and its structure confirmed by X-ray analysis. The sedative and spasmolytic activities of some of these natural products and derivatives were evaluated by applying them to in vivo and in vitro models. Several of these dimeric phthalides displayed sedative and spasmolytic properties that may correlate with some popular uses of L. porteri.

Description

Tokinolide B is isolated from the rhizomes of Ligusticum porter.

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