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1-Cinnamoyl-3-hydroxypyrrolidine

CAS# 1344876-77-2

1-Cinnamoyl-3-hydroxypyrrolidine

Catalog No. BCN6497----Order now to get a substantial discount!

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1-Cinnamoyl-3-hydroxypyrrolidine: 5mg $799 In Stock
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Quality Control of 1-Cinnamoyl-3-hydroxypyrrolidine

Number of papers citing our products

Chemical structure

1-Cinnamoyl-3-hydroxypyrrolidine

3D structure

Chemical Properties of 1-Cinnamoyl-3-hydroxypyrrolidine

Cas No. 1344876-77-2 SDF Download SDF
PubChem ID 62917426 Appearance Powder
Formula C13H15NO2 M.Wt 217.3
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (E)-1-(3-hydroxypyrrolidin-1-yl)-3-phenylprop-2-en-1-one
SMILES C1CN(CC1O)C(=O)C=CC2=CC=CC=C2
Standard InChIKey FHARWVZPAKTDJR-VOTSOKGWSA-N
Standard InChI InChI=1S/C13H15NO2/c15-12-8-9-14(10-12)13(16)7-6-11-4-2-1-3-5-11/h1-7,12,15H,8-10H2/b7-6+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 1-Cinnamoyl-3-hydroxypyrrolidine

The herbs of Piper nigrum

Biological Activity of 1-Cinnamoyl-3-hydroxypyrrolidine

Description1-Cinnamoyl-3-hydroxypyrrolidine is a natural product from Piper nigrum.

Protocol of 1-Cinnamoyl-3-hydroxypyrrolidine

Structure Identification
Planta Med. 2017 Jan;83(1-02):143-50.

Antifungal Amide Alkaloids from the Aerial Parts of Piper flaviflorum and Piper sarmentosum.[Pubmed: 27405106]


METHODS AND RESULTS:
Sixty-three amide alkaloids, including three new, piperflaviflorine A (1), piperflaviflorine B (2), and sarmentamide D (4), and two previously synthesized ones, (1E,3S)-1-Cinnamoyl-3-hydroxypyrrolidine (3) and N-[7'-(4'-methoxyphenyl)ethyl]-2-methoxybenzamide (5), were isolated from the aerial parts of Piper flaviflorum and Piper sarmentosum. Their structures were elucidated by detailed spectroscopic analysis and, in case of 3, by single-crystal X-ray diffraction. Most of the isolates were tested for their antifungal and antibacterial activities.
CONCLUSIONS:
Ten amides (6-15) showed antifungal activity against Cryptococcus neoformans ATCC 90 113 with IC50 values in the range between 4.7 and 20.0 μg/mL.

1-Cinnamoyl-3-hydroxypyrrolidine Dilution Calculator

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1-Cinnamoyl-3-hydroxypyrrolidine Molarity Calculator

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Preparing Stock Solutions of 1-Cinnamoyl-3-hydroxypyrrolidine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.6019 mL 23.0097 mL 46.0193 mL 92.0387 mL 115.0483 mL
5 mM 0.9204 mL 4.6019 mL 9.2039 mL 18.4077 mL 23.0097 mL
10 mM 0.4602 mL 2.301 mL 4.6019 mL 9.2039 mL 11.5048 mL
50 mM 0.092 mL 0.4602 mL 0.9204 mL 1.8408 mL 2.301 mL
100 mM 0.046 mL 0.2301 mL 0.4602 mL 0.9204 mL 1.1505 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 1-Cinnamoyl-3-hydroxypyrrolidine

Antifungal Amide Alkaloids from the Aerial Parts of Piper flaviflorum and Piper sarmentosum.[Pubmed:27405106]

Planta Med. 2017 Jan;83(1-02):143-150.

Sixty-three amide alkaloids, including three new, piperflaviflorine A (1), piperflaviflorine B (2), and sarmentamide D (4), and two previously synthesized ones, (1E,3S)-1-cinnamoyl-3- hydroxypyrrolidine (3) and N-[7'-(4'-methoxyphenyl)ethyl]-2-methoxybenzamide (5), were isolated from the aerial parts of Piper flaviflorum and Piper sarmentosum. Their structures were elucidated by detailed spectroscopic analysis and, in case of 3, by single-crystal X-ray diffraction. Most of the isolates were tested for their antifungal and antibacterial activities. Ten amides (6-15) showed antifungal activity against Cryptococcus neoformans ATCC 90 113 with IC50 values in the range between 4.7 and 20.0 microg/mL.

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