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3'-O-Demethylarctigenin

CAS# 147022-95-5

3'-O-Demethylarctigenin

Catalog No. BCN3544----Order now to get a substantial discount!

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3'-O-Demethylarctigenin: 5mg Please Inquire In Stock
3'-O-Demethylarctigenin: 10mg Please Inquire In Stock
3'-O-Demethylarctigenin: 20mg Please Inquire Please Inquire
3'-O-Demethylarctigenin: 50mg Please Inquire Please Inquire
3'-O-Demethylarctigenin: 100mg Please Inquire Please Inquire
3'-O-Demethylarctigenin: 200mg Please Inquire Please Inquire
3'-O-Demethylarctigenin: 500mg Please Inquire Please Inquire
3'-O-Demethylarctigenin: 1000mg Please Inquire Please Inquire

Quality Control of 3'-O-Demethylarctigenin

Number of papers citing our products

Chemical structure

3'-O-Demethylarctigenin

3D structure

Chemical Properties of 3'-O-Demethylarctigenin

Cas No. 147022-95-5 SDF Download SDF
PubChem ID 384870 Appearance Powder
Formula C20H22O6 M.Wt 358.4
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3R,4R)-3-[(3,4-dihydroxyphenyl)methyl]-4-[(3,4-dimethoxyphenyl)methyl]oxolan-2-one
SMILES COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)O)OC
Standard InChIKey FTDOXLKYCKOSHA-LSDHHAIUSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3'-O-Demethylarctigenin

The root of Arctium lappa L

Biological Activity of 3'-O-Demethylarctigenin

DescriptionStandard reference

Protocol of 3'-O-Demethylarctigenin

Structure Identification
Planta Med. 1994 Oct;60(5):441-4.

Biotransformation of the naturally occurring lignan (-)-arctigenin in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.[Pubmed: 7997474]


METHODS AND RESULTS:
V79 Chinese hamster cells genetically engineered for stable expression of single forms of rat cytochromes P450 1A1, P450 1A2, and P450 2B1, and human P450 1A2 were used to analyse the metabolism of (-)-arctigenin. Concentrations of metabolites formed in the medium were determined by TLC, HPLC, GC, and GC-MS. Only in the cell line expressing rat P450 2B1 was (-)-arctigenin metabolized to a significant extent.
CONCLUSIONS:
The lignan was converted by O-demethylation to (-)-3'-O-Demethylarctigenin.

3'-O-Demethylarctigenin Dilution Calculator

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3'-O-Demethylarctigenin Molarity Calculator

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Preparing Stock Solutions of 3'-O-Demethylarctigenin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7902 mL 13.9509 mL 27.9018 mL 55.8036 mL 69.7545 mL
5 mM 0.558 mL 2.7902 mL 5.5804 mL 11.1607 mL 13.9509 mL
10 mM 0.279 mL 1.3951 mL 2.7902 mL 5.5804 mL 6.9754 mL
50 mM 0.0558 mL 0.279 mL 0.558 mL 1.1161 mL 1.3951 mL
100 mM 0.0279 mL 0.1395 mL 0.279 mL 0.558 mL 0.6975 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 3'-O-Demethylarctigenin

Biotransformation of the naturally occurring lignan (-)-arctigenin in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.[Pubmed:7997474]

Planta Med. 1994 Oct;60(5):441-4.

V79 Chinese hamster cells genetically engineered for stable expression of single forms of rat cytochromes P450 1A1, P450 1A2, and P450 2B1, and human P450 1A2 were used to analyse the metabolism of (-)-arctigenin. Concentrations of metabolites formed in the medium were determined by TLC, HPLC, GC, and GC-MS. Only in the cell line expressing rat P450 2B1 was (-)-arctigenin metabolized to a significant extent. The lignan was converted by O-demethylation to (-)-3'-O-demethylarctigenin.

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