Home >> Research Area >> Ac-YVAD-AFC

Ac-YVAD-AFC

CAS# 219137-85-6

Ac-YVAD-AFC

Catalog No. BCC4022----Order now to get a substantial discount!

Product Name & Size Price Stock
Ac-YVAD-AFC: 5mg $127 In Stock
Ac-YVAD-AFC: 10mg Please Inquire In Stock
Ac-YVAD-AFC: 20mg Please Inquire Please Inquire
Ac-YVAD-AFC: 50mg Please Inquire Please Inquire
Ac-YVAD-AFC: 100mg Please Inquire Please Inquire
Ac-YVAD-AFC: 200mg Please Inquire Please Inquire
Ac-YVAD-AFC: 500mg Please Inquire Please Inquire
Ac-YVAD-AFC: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Ac-YVAD-AFC

Number of papers citing our products

Chemical structure

Ac-YVAD-AFC

3D structure

Chemical Properties of Ac-YVAD-AFC

Cas No. 219137-85-6 SDF Download SDF
PubChem ID 16760708 Appearance Powder
Formula C33H36F3N5O10 M.Wt 719.66
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in DMSO
Chemical Name (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxo-4-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]butanoic acid
SMILES CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C
Standard InChIKey GWKJISJKNKIJNP-DEQDFGQZSA-N
Standard InChI InChI=1S/C33H36F3N5O10/c1-15(2)28(41-31(49)23(38-17(4)42)11-18-5-8-20(43)9-6-18)32(50)37-16(3)29(47)40-24(14-26(44)45)30(48)39-19-7-10-21-22(33(34,35)36)13-27(46)51-25(21)12-19/h5-10,12-13,15-16,23-24,28,43H,11,14H2,1-4H3,(H,37,50)(H,38,42)(H,39,48)(H,40,47)(H,41,49)(H,44,45)/t16-,23-,24-,28-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Ac-YVAD-AFC

DescriptionFluorogenic peptide substrate for caspase-1 (ICE).

Ac-YVAD-AFC Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Ac-YVAD-AFC Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Ac-YVAD-AFC

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.3895 mL 6.9477 mL 13.8955 mL 27.7909 mL 34.7386 mL
5 mM 0.2779 mL 1.3895 mL 2.7791 mL 5.5582 mL 6.9477 mL
10 mM 0.139 mL 0.6948 mL 1.3895 mL 2.7791 mL 3.4739 mL
50 mM 0.0278 mL 0.139 mL 0.2779 mL 0.5558 mL 0.6948 mL
100 mM 0.0139 mL 0.0695 mL 0.139 mL 0.2779 mL 0.3474 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Ac-YVAD-AFC

Ac-YVAD-AFC

Featured Products
New Products
 

References on Ac-YVAD-AFC

Activation of caspase-3 and apoptosis in cerebellar granule cells.[Pubmed:9590441]

J Neurosci Res. 1998 May 1;52(3):334-41.

Caspase-3 activity increased dramatically in cytosolic extracts of rat cerebellar granule cells exposed to apoptotic conditions (basal medium Eagle (BME) containing 5 mM K+ without serum) when assayed with Ac-DEVD-amc, but not with Ac-YVAD-AFC, a preferred substrate for caspase-1. This provided a basis to examine relationships between enzyme activity and cell viability for purposes of selecting an optimal time for comparing neuroprotective agents or strategies. Exposure of neurons to an apoptotic medium containing 5 mM K+ in absence of serum led to a rapid 5- to 10-fold increase in caspase-3 within 2-4 hr but without significant cell loss, or morphological alterations. Exposure to apoptotic medium followed by replacement with maintenance medium containing 25 mM K+ and serum led to a rapid fall in caspase-3 and prevention of cell death. This strategy was not effective after 13 hr exposure despite a large fall in enzyme activity. These temporal changes infer systems for rapid enzyme turnover and/or activation of cytoplasmic components linked to later DNA degradation. The effects of cycloheximide point to requirements for protein synthesis, and those of Glu exclude a caspase-3 dependent pathway for necrotic cell damage. Brief treatment with 10 microM LIGA20, an anti-necrotic agent, also attenuated cell loss and caspase-3 activity, indicating a broad spectrum of neuroprotection. Rapid and long-lasting effects, together with its biophysical properties, suggest that this semisynthetic ganglioside acted upstream at or near a membrane site. As such, gangliosides provide useful agents to further probe pathways relevant to neuronal death in culture.

Keywords:

Ac-YVAD-AFC,219137-85-6,Natural Products, buy Ac-YVAD-AFC , Ac-YVAD-AFC supplier , purchase Ac-YVAD-AFC , Ac-YVAD-AFC cost , Ac-YVAD-AFC manufacturer , order Ac-YVAD-AFC , high purity Ac-YVAD-AFC

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: