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Taraxeryl acetate

CAS# 2189-80-2

Taraxeryl acetate

Catalog No. BCN4937----Order now to get a substantial discount!

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Taraxeryl acetate: 5mg $265 In Stock
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Quality Control of Taraxeryl acetate

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Chemical structure

Taraxeryl acetate

3D structure

Chemical Properties of Taraxeryl acetate

Cas No. 2189-80-2 SDF Download SDF
PubChem ID 5458941 Appearance Powder
Formula C32H52O2 M.Wt 468.8
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(3S,4aR,6aR,8aR,12aR,14aR,14bR)-4,4,6a,6a,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,8,9,10,12,12a,13,14,14a-tetradecahydropicen-3-yl] acetate
SMILES CC(=O)OC1CCC2(C(C1(C)C)CCC3(C2CCC4(C3=CCC5(C4CC(CC5)(C)C)C)C)C)C
Standard InChIKey YWJGYBXHXATAQY-MZVVBVDXSA-N
Standard InChI InChI=1S/C32H52O2/c1-21(33)34-26-13-17-30(7)22(28(26,4)5)11-15-31(8)23-10-14-29(6)19-18-27(2,3)20-25(29)32(23,9)16-12-24(30)31/h10,22,24-26H,11-20H2,1-9H3/t22-,24+,25+,26-,29-,30-,31-,32?/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Taraxeryl acetate

The herb of Taraxacum mongolicum Hand. Mazz.

Biological Activity of Taraxeryl acetate

Description1. Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). 2. Taraxeryl acetate has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol. 3. A. roxburghiana has antidiabetic activity, could be attributed due to PTP1B inhibition by its triterpene constituents, betulin, betulinic acid and Taraxeryl acetate.
TargetsHSV

Taraxeryl acetate Dilution Calculator

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Taraxeryl acetate Molarity Calculator

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Preparing Stock Solutions of Taraxeryl acetate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1331 mL 10.6655 mL 21.3311 mL 42.6621 mL 53.3276 mL
5 mM 0.4266 mL 2.1331 mL 4.2662 mL 8.5324 mL 10.6655 mL
10 mM 0.2133 mL 1.0666 mL 2.1331 mL 4.2662 mL 5.3328 mL
50 mM 0.0427 mL 0.2133 mL 0.4266 mL 0.8532 mL 1.0666 mL
100 mM 0.0213 mL 0.1067 mL 0.2133 mL 0.4266 mL 0.5333 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Taraxeryl acetate

Antimicrobial activity of the crude extract, fractions and compounds from stem bark of Ficus ovata (Moraceae).[Pubmed:19450673]

J Ethnopharmacol. 2009 Jul 30;124(3):556-61.

AIM OF THE STUDY: This study was designed to investigate the antimicrobial activities of the methanol extracts from the stem bark of Ficus ovata (FOB), fractions (FOB1-6) and compounds isolated following bio-guided fractionation [3-friedelanone (1), Taraxeryl acetate (2), betulinic acid (3), oleanoic acid (4), 2-hydroxyisoprunetin (5), 6,7-(2-isopropenyl furo)-5,2,4-trihydroxyisoflavone (6), Cajanin (7) and protocatechuic acid (8)]. MATERIALS AND METHODS: The micro-dilution method was used for the determination of the minimal inhibition concentration (MIC) and the minimal microbicidal concentration (MMC) against fungi (two species), gram-positive (three species) and gram-negative bacteria (five species). RESULTS: The results of the MIC determinations indicated that the crude extract (FOB), fractions FOB2 and FOB4 as well as compound 5 were active on the entire studied organisms. Other samples showed selective activity, fractions FOB1, FOB3 and FOB5 being active against 50% of the tested microbial species while FOB6 was active on 40%. Compounds 8, 6, 2 and 7 prevented the growth of 80%, 70%, 50% and 20% of the organisms respectively. The lowest MIC value (156 g/ml) observed with the crude extract was recorded on Streptococcus faecalis, Candida albicans and Microsporum audouinii. The corresponding value for fractions (39 microg/ml) was noted with FOB4 against Staphylococcus aureus, while that of the tested compounds (10 microg/ml) was observed with compound 8 on Microsporum audouinii. The results of the MMC determination suggested that the cidal effect of most of the tested samples on the studied microorganisms could be expected. CONCLUSIONS: The overall results provided evidence that the studied plant extract, as well as some of the isolated compounds might be potential sources of new antimicrobial drug.

Protein tyrosine phosphatase 1B inhibitors isolated from Artemisia roxburghiana.[Pubmed:26118418]

J Enzyme Inhib Med Chem. 2016 Aug;31(4):563-7.

Artemisia roxburghiana is used in traditional medicine for treating various diseases including diabetes. The present study was designed to evaluate the antidiabetic potential of active constituents by using protein tyrosine phosphatase 1B (PTP1B) as a validated target for management of diabetes. Various compounds were isolated as active principles from the crude methanolic extract of aerial parts of A. roxburghiana. All compounds were screened for PTP1B inhibitory activity. Molecular docking simulations were performed to investigate the mechanism behind PTP1B inhibition of the isolated compound and positive control, ursolic acid. Betulinic acid, betulin and Taraxeryl acetate were the active PTP1B principles with IC50 values 3.49 +/- 0.02, 4.17 +/- 0.03 and 87.52 +/- 0.03 microM, respectively. Molecular docking studies showed significant molecular interactions of the triterpene inhibitors with Gly220, Cys215, Gly218 and Asp48 inside the active site of PTP1B. The antidiabetic activity of A. roxburghiana could be attributed due to PTP1B inhibition by its triterpene constituents, betulin, betulinic acid and Taraxeryl acetate. Computational insights of this study revealed that the C-3 and C-17 positions of the compounds needs extensive optimization for the development of new lead compounds.

Description

Taraxerol acetate is a COX-1 and COX-2 inhibitor with IC50 values of 116.3 μM and 94.7 μM, respectively. Taraxerol acetate the has the anticancer potential and induces cell apoptosis.

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