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Ajugasterone C

CAS# 23044-80-6

Ajugasterone C

Catalog No. BCN2757----Order now to get a substantial discount!

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Ajugasterone C: 5mg $213 In Stock
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Quality Control of Ajugasterone C

Number of papers citing our products

Chemical structure

Ajugasterone C

3D structure

Chemical Properties of Ajugasterone C

Cas No. 23044-80-6 SDF Download SDF
PubChem ID 441826 Appearance Powder
Formula C27H44O7 M.Wt 480.64
Type of Compound Steroids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S,3R,5R,9R,10R,11R,13R,14S,17S)-17-[(2R,3R)-2,3-dihydroxy-6-methylheptan-2-yl]-2,3,11,14-tetrahydroxy-10,13-dimethyl-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one
SMILES CC(C)CCC(C(C)(C1CCC2(C1(CC(C3C2=CC(=O)C4C3(CC(C(C4)O)O)C)O)C)O)O)O
Standard InChIKey LQGNCUXDDPRDJH-UKTRSHMFSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ajugasterone C

The herbs of Ajuga ciliata Bunge.

Biological Activity of Ajugasterone C

DescriptionAjugasterone C shows significant inhibitory effect at 100 mg/kg dose on rat paw oedema development due to carrageenan-induced inflammation in Sprague Dawley rats.
TargetsImmunology & Inflammation related
In vivo

Phytoecdysteroids from the stem bark of Vitex doniana and their anti-inflammatory effects.[Pubmed: 23150078 ]

Planta Med. 2013 Jan;79(1):52-9.

With reference to the ethnopharmacological significance of Vitex doniana Sweet (Lamiaceae) leaves in the treatment of stomach and rheumatic pains as well as inflammatory disorders, biological studies on its stem bark extracts have also reported anti-inflammatory and analgesic activities, with no attempt to identify the active components.
METHODS AND RESULTS:
Chromatographic and spectroscopic procedures identified three new phytoecdysteroids: 21-hydroxyshidasterone (1), 11β-hydroxy-20-deoxyshidasterone (2), and 2,3-acetonide-24-hydroxyecdysone (3) from the stem bark methanol extracts along with known ecdysteroids shidasterone (4), Ajugasterone C (5), 24-hydroxyecdysone (6), and 11β,24-hydroxyecdysone (7). The compounds (1-7) showed significant (p ≤ 0.05) inhibitory effect at 100 mg/kg dose on rat paw oedema development due to carrageenan-induced inflammation in Sprague Dawley rats.
CONCLUSIONS:
These results suggest a possible contribution of ecdysteroids to the anti-inflammatory effect of some V. doniana stem bark extracts.

Ajugasterone C Dilution Calculator

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Ajugasterone C Molarity Calculator

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Preparing Stock Solutions of Ajugasterone C

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0806 mL 10.4028 mL 20.8056 mL 41.6112 mL 52.014 mL
5 mM 0.4161 mL 2.0806 mL 4.1611 mL 8.3222 mL 10.4028 mL
10 mM 0.2081 mL 1.0403 mL 2.0806 mL 4.1611 mL 5.2014 mL
50 mM 0.0416 mL 0.2081 mL 0.4161 mL 0.8322 mL 1.0403 mL
100 mM 0.0208 mL 0.104 mL 0.2081 mL 0.4161 mL 0.5201 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Ajugasterone C

Phytoecdysteroids from the stem bark of Vitex doniana and their anti-inflammatory effects.[Pubmed:23150078]

Planta Med. 2013 Jan;79(1):52-9.

With reference to the ethnopharmacological significance of Vitex doniana Sweet (Lamiaceae) leaves in the treatment of stomach and rheumatic pains as well as inflammatory disorders, biological studies on its stem bark extracts have also reported anti-inflammatory and analgesic activities, with no attempt to identify the active components. Chromatographic and spectroscopic procedures identified three new phytoecdysteroids: 21-hydroxyshidasterone (1), 11beta-hydroxy-20-deoxyshidasterone (2), and 2,3-acetonide-24-hydroxyecdysone (3) from the stem bark methanol extracts along with known ecdysteroids shidasterone (4), Ajugasterone C (5), 24-hydroxyecdysone (6), and 11beta,24-hydroxyecdysone (7). The compounds (1-7) showed significant (p

Description

Ajugasterone C is an ecdysteroid isolated from Leuzea carthamoides. Ajugasterone C shows significant inhibitory effect at 100 mg/kg dose on rat paw oedema development due to Carrageenan-induced inflammation in Sprague Dawley rats.

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