Neoglycyrol

CAS# 23013-84-5

Neoglycyrol

Catalog No. BCN2907----Order now to get a substantial discount!

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Neoglycyrol: 5mg $161 In Stock
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Quality Control of Neoglycyrol

Number of papers citing our products

Chemical structure

Neoglycyrol

3D structure

Chemical Properties of Neoglycyrol

Cas No. 23013-84-5 SDF Download SDF
PubChem ID 5320083 Appearance Powder
Formula C21H18O6 M.Wt 366.4
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3,9-dihydroxy-1-methoxy-2-(3-methylbut-2-enyl)-[1]benzofuro[3,2-c]chromen-6-one
SMILES CC(=CCC1=C(C=C2C(=C1OC)C3=C(C4=C(O3)C=C(C=C4)O)C(=O)O2)O)C
Standard InChIKey LWESBHWAOZORCQ-UHFFFAOYSA-N
Standard InChI InChI=1S/C21H18O6/c1-10(2)4-6-12-14(23)9-16-18(19(12)25-3)20-17(21(24)27-16)13-7-5-11(22)8-15(13)26-20/h4-5,7-9,22-23H,6H2,1-3H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Neoglycyrol

The roots of Glycyrrhiza uralensis Fisch

Biological Activity of Neoglycyrol

DescriptionNeoglycyrol shows some cardioprotective effects .
In vitro

Screening of active compounds with myocardial protective effects from Tongmai Yangxin pill[Pubmed: 26038132]

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015 Mar;44(2):145-53.

Based on cell model and HPLC-MS technology, to screen myocardial protection active compounds from traditional patent medicine Tongmai Yangxin pill (TMYXP).
METHODS AND RESULTS:
Fractions of TMYXP were prepared by high performance liquid preparation technology. The cardioprotective effects of prepared fractions were tested on H2O2 oxidation-damaged H9c2 myocardiocytes. The active components were analyzed by high performance liquid chromatography (HPLC) coupled with high resolution mass spectrometry. The possible active compounds were putatively identified by comparison of their MS ions and molecular weight with literatures. Ten TMYXP components presented significant myocardial protective activities, 5 of which were investigated and presented good dose-effect relationships. Their median effective concentrations (EC50) were respectively 11.66, 17.44, 13.10, 7.332, 15.15 μg/mL. Totally, 11 potential active compounds were analyzed and identified, including Glycyrrhizic acid, Glycycoumarin, Licoisoflavone, Ophiopogonin D', Licoricon, Gancaonin L, Neoglycyrol, Emodin, Angeloylgomisin H, Angeloylgomisin Q and Glyasperin A.
CONCLUSIONS:
The myocardial protection active compounds of TMYXP were screened successfully.

Neoglycyrol Dilution Calculator

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Neoglycyrol Molarity Calculator

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Preparing Stock Solutions of Neoglycyrol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7293 mL 13.6463 mL 27.2926 mL 54.5852 mL 68.2314 mL
5 mM 0.5459 mL 2.7293 mL 5.4585 mL 10.917 mL 13.6463 mL
10 mM 0.2729 mL 1.3646 mL 2.7293 mL 5.4585 mL 6.8231 mL
50 mM 0.0546 mL 0.2729 mL 0.5459 mL 1.0917 mL 1.3646 mL
100 mM 0.0273 mL 0.1365 mL 0.2729 mL 0.5459 mL 0.6823 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Neoglycyrol

[Screening of active compounds with myocardial protective effects from Tongmai Yangxin pill].[Pubmed:26038132]

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015 Mar;44(2):145-53.

OBJECTIVE: Based on cell model and HPLC-MS technology, to screen myocardial protection active compounds from traditional patent medicine Tongmai Yangxin pill (TMYXP). METHODS: Fractions of TMYXP were prepared by high performance liquid preparation technology. The cardioprotective effects of prepared fractions were tested on H2O2 oxidation-damaged H9c2 myocardiocytes. The active components were analyzed by high performance liquid chromatography (HPLC) coupled with high resolution mass spectrometry. The possible active compounds were putatively identified by comparison of their MS ions and molecular weight with literatures. RESULTS: Ten TMYXP components presented significant myocardial protective activities, 5 of which were investigated and presented good dose-effect relationships. Their median effective concentrations (EC50) were respectively 11.66, 17.44, 13.10, 7.332, 15.15 mug/mL. Totally, 11 potential active compounds were analyzed and identified, including Glycyrrhizic acid, Glycycoumarin, Licoisoflavone, Ophiopogonin D', Licoricon, Gancaonin L, Neoglycyrol, Emodin, Angeloylgomisin H, Angeloylgomisin Q and Glyasperin A. CONCLUSION: The myocardial protection active compounds of TMYXP were screened successfully.

Description

Neoglycyrol is isolated from the root of Glycyrrhiza uralensis Fisch. Neoglycyrol is a potential myocardial protection active compound screened from traditional patent medicine Tongmai Yangxin pill (TMYXP).

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