Atractylic acid dipotassium saltANT inhibitor CAS# 102130-43-8 |
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Quality Control & MSDS
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Chemical structure
3D structure
| Cas No. | 102130-43-8 | SDF | Download SDF |
| PubChem ID | 5702200 | Appearance | Powder |
| Formula | C30H44K2O16S2 | M.Wt | 802.99 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | DMSO : 250 mg/mL (311.34 mM; Need ultrasonic) H2O : 100 mg/mL (124.53 mM; Need ultrasonic) | ||
| SMILES | CC(C)CC(=O)OC1C(C(C(OC1OC2CC(C3CCC45CC(CCC4C3(C2)C)C(=C)C5O)C(=O)O)CO)OS(=O)(=O)[O-])OS(=O)(=O)[O-].[K+].[K+] | ||
| Standard InChIKey | IUCNQFHEWLYECJ-UAPRPQGYSA-L | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Atractyloside potassium salt inhibits oxidative phosphorylation by blocking the transfer of adenosine nucleotides through the mitochondrial membrane. |
Atractylic acid dipotassium salt Dilution Calculator
Atractylic acid dipotassium salt Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.2453 mL | 6.2267 mL | 12.4535 mL | 24.9069 mL | 31.1336 mL |
| 5 mM | 0.2491 mL | 1.2453 mL | 2.4907 mL | 4.9814 mL | 6.2267 mL |
| 10 mM | 0.1245 mL | 0.6227 mL | 1.2453 mL | 2.4907 mL | 3.1134 mL |
| 50 mM | 0.0249 mL | 0.1245 mL | 0.2491 mL | 0.4981 mL | 0.6227 mL |
| 100 mM | 0.0125 mL | 0.0623 mL | 0.1245 mL | 0.2491 mL | 0.3113 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Atractyloside Dipotassium Salt is an inhibitor of ADP/ATP Translocase.
ATP-ADP translocase (AAT) is a mitochondrial ADP/ATP carrier. It transports ATP from the mitochondrial matrix to the cytoplasm and transports ADP from the cytoplasm to the mitochondrial matrix.
In Ehrlich ascites tumor cells, atractyloside (3 mM) inhibited cells growth by 70%. The mitochondria became spherical shaped with translucent matrix rid of cristae. When transfered to normal medium, proliferation and macromolecular synthesis recovered to normal levels within 3 to 6 h [2].
In the sarcoplasmic reticulum vesicles from the rabbit skeletal muscle with 10 μM of cytoplasmic Ca2+, atractyloside reduced the rate of choline+ influx through the Ca2+ channels to 60%. Also, it inhibited about half of Ca2+ channels incorporated into planar bilayers [1]. In mitochondrial membranes isolated from a rat heart muscle, atractyloside (5-100 μM) inhibited the chloride channels in dose-dependent way [3].
References:
[1]. Yamaguchi N, Kagari T, Kasai M. Inhibition of the ryanodine receptor calcium channel in the sarcoplasmic reticulum of skeletal muscle by an ADP/ATP translocase inhibitor, atractyloside. Biochem Biophys Res Commun, 1999, 258(2): 247-251.
[2]. Pick-Kober KH, Schneider F. Proliferation, macromolecular synthesis and energy metabolism of in vitro grown Ehrlich ascites tumor cells after inhibition of ATP-ADP translocation by atractyloside. Eur J Cell Biol, 1984, 34(2): 323-329.
[3]. Malekova L, Kominkova V, Ferko M, et al. Bongkrekic acid and atractyloside inhibits chloride channels from mitochondrial membranes of rat heart. Biochim Biophys Acta, 2007, 1767(1): 31-44.
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