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Cefozopran hydrochloride

CAS# 113981-44-5

Cefozopran hydrochloride

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Quality Control of Cefozopran hydrochloride

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Chemical structure

Cefozopran hydrochloride

3D structure

Chemical Properties of Cefozopran hydrochloride

Cas No. 113981-44-5 SDF Download SDF
PubChem ID 5491954 Appearance Powder
Formula C19H18ClN9O5S2 M.Wt 552.0
Type of Compound N/A Storage Desiccate at -20°C
Synonyms SCE-2787 hydrochloride
Solubility H2O : ≥ 52 mg/mL (94.20 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name (6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl]amino]-3-(imidazo[1,2-b]pyridazin-4-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;chloride
SMILES CON=C(C1=NSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)CN4C=C[N+]5=C4C=CC=N5)C(=O)O.[Cl-]
Standard InChIKey NTJHUKMPVIFDNY-XFDPNJHTSA-N
Standard InChI InChI=1S/C19H17N9O5S2.ClH/c1-33-24-11(14-23-19(20)35-25-14)15(29)22-12-16(30)28-13(18(31)32)9(8-34-17(12)28)7-26-5-6-27-10(26)3-2-4-21-27;/h2-6,12,17H,7-8H2,1H3,(H3-,20,22,23,25,29,31,32);1H/b24-11-;/t12-,17-;/m1./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Cefozopran hydrochloride Dilution Calculator

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Cefozopran hydrochloride Molarity Calculator

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Preparing Stock Solutions of Cefozopran hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8116 mL 9.058 mL 18.1159 mL 36.2319 mL 45.2899 mL
5 mM 0.3623 mL 1.8116 mL 3.6232 mL 7.2464 mL 9.058 mL
10 mM 0.1812 mL 0.9058 mL 1.8116 mL 3.6232 mL 4.529 mL
50 mM 0.0362 mL 0.1812 mL 0.3623 mL 0.7246 mL 0.9058 mL
100 mM 0.0181 mL 0.0906 mL 0.1812 mL 0.3623 mL 0.4529 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Cefozopran hydrochloride

Cefozopran Hcl(SCE 2787 Hcl) is a fourth-generation cephalosporin. Target: Antibacterial Cefozopran is a fourth-generation cephalosporin.

References:
[1]. http://www.toku-e.com/Assets/MIC/Cefozopran%20hydrochloride.pdf

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References on Cefozopran hydrochloride

DEVELOPMENT AND VALIDATION OF THE STABILITY-INDICATING LC-UV METHOD FOR DETERMINATION OF CEFOZOPRAN HYDROCHLORIDE.[Pubmed:26642650]

Acta Pol Pharm. 2015 May-Jun;72(3):423-7.

The stability-indicating LC assay method was developed and validated for quantitative determination of Cefozopran hydrochloride (CZH) in the presence of degradation products formed during the forced degradation studies. An isocratic, RP-HPLC method was developed with C-18 (250 mm x 4.6 mm, 5 microm) column and 12 mM ammonium acetate-acetonitrile (92:8, v/v) as a mobile phase. The flow rate of the mobile phase was 1.0 mL/min. Detection wavelength was 260 not and temperature was 30 degrees C. Cefozopran hydrochloride as other cephalosporins was subjected to stress conditions of degradation in aqueous solutions including hydrolysis, oxidation, photolysis and thermal degradation. The developed method was validated with regard to linearity, accuracy, precision, selectivity and robustness. The method was applied successfully for identification and determination of Cefozopran hydrochloride in pharmaceuticals and during kinetic studies.

[Pharmacokinetics of injected cefozopran hydrochloride in healthy volunteers].[Pubmed:23230745]

Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 Sep;43(5):711-4.

OBJECTIVE: To study the pharmacokinetics of injected Cefozopran hydrochloride in healthy volunteers. METHODS: 24 healthy volunteers were enrolled to receive low (0.5 g), middle (1.0 g), high (2.0 g) doses of single injection and multiple doses (1.0 g) injection of Cefozopran hydrochloride in an open randomized study. The plasma concentrations of cefozopran were determined by RP-HPLC. The DAS2.0 was used to fit the concentration-time data and to calculate the pharmacokinetic parameters. RESULTS: The main pharmaeokinetic parameters for a single injection of low, middle and high doses of cefozopran were as follows: Cmax (48.27 +/- 9.84), (77.99 +/- 15.08) and (171.59 +/- 18.27) mg/L; Tmax (0.50 +/- 0.00), (0.51 +/- 0.02) and (0.51 + 0.02) h; AUCo-t (92.43 +/- 24.02), (152.45 +/- 16.26) and (341.03 +/- 44.16) mg x h/L; t1/2beta (1.97 +/- 0.19), (2.44 +/- 0.24) and (2.18 +/- 0.31) h, respectively. The main pharmacokinetic parameters for a multiple doses injection of cefozopran were as follows: Cmax (80.39 +/- 11.86) mg/L; Tmax (0.51 +/- 0.02) h; AUCo-t (159.74 +/- 15.06) mg x h/L; t1/2beta (2.55 +/- 0.55) h. The accumulative rate of cefozopran through urine pathway within 24 h was (89.4 +/- 15.5)%. The statistical analysis showed that Cmax, AUCo-t, and AUCo-infinity increased significantly with increased doses of injection (P < 0.05). Those parameters were linearly correlated with the doses of injection (r = 0.9950, 0.9960, 0.9963). However, dosage did not have an impact on other pharmacokinetic parameters (P > 0.05). No gender differences in the parameters were found (P > 0.05). CONCLUSION: Cefozopran hydrochloride performs a linear kinetics in healthy volunteers. The main pharmacokinetic parameters have no significant gender differences, and there is no drug accumulated with multiple doses of injection.

Description

Cefozopran Hcl(SCE 2787 Hcl) is a fourth-generation cephalosporin.

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