FFN 511

Fluorescent substrate for VMAT2 CAS# 1004548-96-2

FFN 511

Catalog No. BCC7799----Order now to get a substantial discount!

Product Name & Size Price Stock
FFN 511: 5mg $138 In Stock
FFN 511: 10mg Please Inquire In Stock
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Quality Control of FFN 511

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Chemical structure

FFN 511

3D structure

Chemical Properties of FFN 511

Cas No. 1004548-96-2 SDF Download SDF
PubChem ID 91885442 Appearance Powder
Formula C17H20N2O2 M.Wt 284.35
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 25 mM in 1eq. HCl and to 5 mM in DMSO
SMILES C1CC2=C3C(=C4C(=C2)C(=CC(=O)O4)CCN)CCCN3C1.C(=O)(C(F)(F)F)O
Standard InChIKey XHUSAIWAUAMZRG-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H20N2O2.C2HF3O2/c18-6-5-11-10-15(20)21-17-13-4-2-8-19-7-1-3-12(16(13)19)9-14(11)17;3-2(4,5)1(6)7/h9-10H,1-8,18H2;(H,6,7)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of FFN 511

DescriptionFluorescent false neurotransmitter (FFN). Targets neuronal vesicular monoamine transporter (VMAT) 2; inhibits serotonin binding to VMAT2 (IC50 = 1 μM).

FFN 511 Dilution Calculator

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FFN 511 Molarity Calculator

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Preparing Stock Solutions of FFN 511

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5168 mL 17.584 mL 35.1679 mL 70.3359 mL 87.9198 mL
5 mM 0.7034 mL 3.5168 mL 7.0336 mL 14.0672 mL 17.584 mL
10 mM 0.3517 mL 1.7584 mL 3.5168 mL 7.0336 mL 8.792 mL
50 mM 0.0703 mL 0.3517 mL 0.7034 mL 1.4067 mL 1.7584 mL
100 mM 0.0352 mL 0.1758 mL 0.3517 mL 0.7034 mL 0.8792 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on FFN 511

Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals.[Pubmed:19423778]

Science. 2009 Jun 12;324(5933):1441-4.

The nervous system transmits signals between neurons via neurotransmitter release during synaptic vesicle fusion. In order to observe neurotransmitter uptake and release from individual presynaptic terminals directly, we designed fluorescent false neurotransmitters as substrates for the synaptic vesicle monoamine transporter. Using these probes to image dopamine release in the striatum, we made several observations pertinent to synaptic plasticity. We found that the fraction of synaptic vesicles releasing neurotransmitter per stimulus was dependent on the stimulus frequency. A kinetically distinct "reserve" synaptic vesicle population was not observed under these experimental conditions. A frequency-dependent heterogeneity of presynaptic terminals was revealed that was dependent in part on D2 dopamine receptors, indicating a mechanism for frequency-dependent coding of presynaptic selection.

Dopamine release at individual presynaptic terminals visualized with FFNs.[Pubmed:19721412]

J Vis Exp. 2009 Aug 31;(30). pii: 1562.

The nervous system transmits signals between neurons via neurotransmitter release during synaptic vesicle fusion. To observe neurotransmitter uptake and release from individual presynaptic terminals directly, we designed fluorescent false neurotransmitters as substrates for the synaptic vesicle monoamine transporter. Using these probes to image dopamine release in the striatum, we made several observations pertinent to synaptic plasticity. We found that the fraction of synaptic vesicles releasing neurotransmitter per stimulus was dependent on the stimulus frequency. A kinetically distinct "reserve" synaptic vesicle population was not observed under these experimental conditions. A frequency-dependent heterogeneity of presynaptic terminals was revealed that was dependent in part on D2 dopamine receptors, indicating a mechanism for frequency-dependent coding of presynaptic selection.

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