Rosiridin

CAS# 100462-37-1

Rosiridin

Catalog No. BCN5970----Order now to get a substantial discount!

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Rosiridin: 5mg $184 In Stock
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Quality Control of Rosiridin

Number of papers citing our products

Chemical structure

Rosiridin

3D structure

Chemical Properties of Rosiridin

Cas No. 100462-37-1 SDF Download SDF
PubChem ID 10314695 Appearance Oil
Formula C16H28O7 M.Wt 332.39
Type of Compound Monoterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2R,3R,4S,5S,6R)-2-[(2E)-4-hydroxy-3,7-dimethylocta-2,6-dienoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
SMILES CC(=CCC(C(=CCOC1C(C(C(C(O1)CO)O)O)O)C)O)C
Standard InChIKey PBPYEEMQIFDGSQ-MIYBPCGNSA-N
Standard InChI InChI=1S/C16H28O7/c1-9(2)4-5-11(18)10(3)6-7-22-16-15(21)14(20)13(19)12(8-17)23-16/h4,6,11-21H,5,7-8H2,1-3H3/b10-6+/t11?,12-,13-,14+,15-,16-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Rosiridin

The herb of Rhodiola rosea L.

Biological Activity of Rosiridin

DescriptionRosiridin has cardioprotective activity.
In vitro

The determination of rosiridin in effect extracts of anti-coronary atherosclerotic heart disease of Rhodiola rosea by HPLC[Reference: WebLink]

Journal of Xinjiang Medical University,2007, 30(2):127-9.

To develop an assay method for determining the concentrations of Rosiridin in effect extracts of anti-coronary atherosclerotic heart disease of Rhodiola rosea.
METHODS AND RESULTS:
High performance liquid chromatography detection (HPLC) was used, using a ODS C18 column (250 mm×4.6 mm, 5 μm) set at 35℃, methanol-water (35∶65) as mobile phase with flowing rate 0.8 ml/min and detected at 210 nm. The linear range of Rosiridin was 5.5~550 μg/ml (r=0.999 6), and the average recovery (n=9) was 98.5%, RSD=1.3%.
CONCLUSIONS:
This method is simple, accurate and reproducible. It provides a basis for the quality evaluation for effect extracts of anti-coronary atherosclerotic heart disease of Rhodiola rosea.

Protocol of Rosiridin

Structure Identification
Chem Pharm Bull (Tokyo). 2008 May;56(5):695-700.

Reinvestigation of absolute stereostructure of (-)-rosiridol: structures of monoterpene glycosides, rosiridin, rosiridosides A, B, and C, from Rhodiola sachalinensis.[Pubmed: 18451561]

Three new (-)-rosiridol glycosides, rosiridosides A, B, and C, were isolated from the roots of Rhodiola sachalinensis together with Rosiridin [(-)-rosiridol 1-O-beta-D-glucopyranoside]. In the course of the structure elucidation of those new glycosides, the absolute configuration of the 4-position in (-)-rosiridol was reinvestigated. On the basis of the application of the modified Mosher's method for (-)- and (+)-rosiridol derivatives, the absolute configuration of the 4-position in (-)-rosiridol should be revised to be S orientation from the recently assigned R form, so that the absolute stereostructures of rosiridosides A, B, and C and Rosiridin were determined.

Rosiridin Dilution Calculator

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Rosiridin Molarity Calculator

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Preparing Stock Solutions of Rosiridin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0085 mL 15.0426 mL 30.0851 mL 60.1703 mL 75.2129 mL
5 mM 0.6017 mL 3.0085 mL 6.017 mL 12.0341 mL 15.0426 mL
10 mM 0.3009 mL 1.5043 mL 3.0085 mL 6.017 mL 7.5213 mL
50 mM 0.0602 mL 0.3009 mL 0.6017 mL 1.2034 mL 1.5043 mL
100 mM 0.0301 mL 0.1504 mL 0.3009 mL 0.6017 mL 0.7521 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Rosiridin

Reinvestigation of absolute stereostructure of (-)-rosiridol: structures of monoterpene glycosides, rosiridin, rosiridosides A, B, and C, from Rhodiola sachalinensis.[Pubmed:18451561]

Chem Pharm Bull (Tokyo). 2008 May;56(5):695-700.

Three new (-)-rosiridol glycosides, rosiridosides A, B, and C, were isolated from the roots of Rhodiola sachalinensis together with Rosiridin [(-)-rosiridol 1-O-beta-D-glucopyranoside]. In the course of the structure elucidation of those new glycosides, the absolute configuration of the 4-position in (-)-rosiridol was reinvestigated. On the basis of the application of the modified Mosher's method for (-)- and (+)-rosiridol derivatives, the absolute configuration of the 4-position in (-)-rosiridol should be revised to be S orientation from the recently assigned R form, so that the absolute stereostructures of rosiridosides A, B, and C and Rosiridin were determined.

Description

Rosiridin, which is isolated from Rhodiola rosea L., inhibits MAO A and MAO B with potential beneficial effect in depression and senile dementia. Rosiridin shows an inhibition of 83.8% against MAO B at 10 μM (pIC50=5.38).

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