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Protoveratrine B

CAS# 124-97-0

Protoveratrine B

Catalog No. BCN2435----Order now to get a substantial discount!

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Quality Control of Protoveratrine B

Number of papers citing our products

Chemical structure

Protoveratrine B

3D structure

Chemical Properties of Protoveratrine B

Cas No. 124-97-0 SDF Download SDF
PubChem ID 222158 Appearance Powder
Formula C41H63NO15 M.Wt 809.9
Type of Compound Alkaloids Storage Desiccate at -20°C
Synonyms Veratetrine;Neoprotoveratrin;Neoprotoveratrine
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1S,2S,6S,9S,10S,11R,12R,13S,14S,15S,16S,17R,18R,19S,22S,23S,25R)-16,17-diacetyloxy-10,12,14,23-tetrahydroxy-6,10,19-trimethyl-13-[(2R)-2-methylbutanoyl]oxy-24-oxa-4-azaheptacyclo[12.12.0.02,11.04,9.015,25.018,23.019,25]hexacosan-22-yl] (2R,3R)-2,3-dihydroxy-2-methylbutanoate
SMILES CCC(C)C(=O)OC1C(C2C(CN3CC(CCC3C2(C)O)C)C4C1(C5C(C(C6C7(C5(C4)OC6(C(CC7)OC(=O)C(C)(C(C)O)O)O)C)OC(=O)C)OC(=O)C)O)O
Standard InChIKey BFLXOMFFVWQPAZ-CEEVVQPDSA-N
Standard InChI InChI=1S/C41H63NO15/c1-10-19(3)34(47)56-33-28(46)27-23(17-42-16-18(2)11-12-25(42)38(27,9)50)24-15-39-32(40(24,33)51)30(54-22(6)45)29(53-21(5)44)31-36(39,7)14-13-26(41(31,52)57-39)55-35(48)37(8,49)20(4)43/h18-20,23-33,43,46,49-52H,10-17H2,1-9H3/t18-,19+,20+,23-,24-,25-,26-,27+,28+,29-,30+,31-,32+,33-,36-,37+,38+,39+,40-,41+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Protoveratrine B

The herb of Sophora alopecuroidos L.

Protoveratrine B Dilution Calculator

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Protoveratrine B Molarity Calculator

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Preparing Stock Solutions of Protoveratrine B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2347 mL 6.1736 mL 12.3472 mL 24.6944 mL 30.868 mL
5 mM 0.2469 mL 1.2347 mL 2.4694 mL 4.9389 mL 6.1736 mL
10 mM 0.1235 mL 0.6174 mL 1.2347 mL 2.4694 mL 3.0868 mL
50 mM 0.0247 mL 0.1235 mL 0.2469 mL 0.4939 mL 0.6174 mL
100 mM 0.0123 mL 0.0617 mL 0.1235 mL 0.2469 mL 0.3087 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Protoveratrine B

Inhibition of some new cardiotonic agents by tetrodotoxin.[Pubmed:2434106]

Arzneimittelforschung. 1986 Oct;36(10):1461-3.

The effects of sulmazole, milrinone and 1,5-dihydro-6-chloro-3-methylimidazo[2,1-b]quinazolone-2 on guinea pig left atria were studied, measuring the force of contraction in the absence and in the presence of 1 x 10(-5) mol/l octahydro-12-(hydroxymethyl)-2-imino-5,9: 7,10a-dimethano-10aH-[1,3]-dioxocino[6,5-d]pyrimidine- 4,7,10, 11,12-pentol (tetrodotoxin, TTX). The dihydropyridine derivative methyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-tri-fluoromethylphenyl) pyridine-5-carboxylate, a Ca2+ agonist, was also tested. Protoveratrine B, which prolongs the Na+ current phase, was inhibited by TTX. Isoprenaline, whose activity is mediated by cyclic adenosine monophosphate and consequently by the increase in slow inward Ca2+ current, was not. TTX antagonized competitively sulmazole, milrinone and the quinazolone drug and reduced only the activity of the dihydropyridine derivative. These results suggest an interference of the new cardiotonic drugs with the fast Na+ channel.

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