Aucklandia lappa
Aucklandia lappa
Aucklandia lappa is a plant whose rhizome is commonly used in Traditional Chinese medicine. Compounds in the rhizome are thought to have anti-fungal, anti-oxidant and anti-cancer properties. Dehydrocostuslactone and costunolide have been isolated from the rhizome. Aucklandia lappa Decne, a well-known traditional herbal medicine, is used for the treatment of asthma, rheumatism, coughs, tuberculosis and numerous other diseases. The present study evaluated the inhibitory effects of the three sesquiterpene lactones costunolide, dehydrocostus lactone, and alantolactone, isolated from a 70% methanolic extract of Aucklandia lappa, on the expression of chemokine mRNA in HaCaT human keratinocyte cells. The cytotoxicities of the compounds on HaCaT cells were evaluated using a Cell Counting Kit8 assay. Furthermore, the inhibitory effects of the three compounds on chemokine expression in tumor necrosis factor (TNF)‑α‑ and interferon (IFN)‑γ‑stimulated HaCaT cells were analyzed by reverse transcription-polymerase chain reaction analysis.
Products from Aucklandia lappa
- Cat.No. Product Name CAS Number COA
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BCN5536
Dehydrocostus lactone 477-43-0
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BCN5740
Costunolide 553-21-9
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BCN4955
Isoalantolactone 470-17-7
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BCN1033
Alantolactone 546-43-0
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BCN1015
Beta-Sitosterol 83-46-5
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BCN4376
Stigmasterol 83-48-7
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BCN1206
Palmitic acid 57-10-3
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BCN3821
Linoleic acid 60-33-3
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BCN5324
beta-Costic acid 3650-43-9
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BCN5528
Betulin 473-98-3
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BCN6170
5beta-Hydroxycostic acid 132185-84-3
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BCN6169
5alpha-Hydroxycostic acid 132185-83-2
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BCN6059
Syringin 118-34-3
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BCN5524
Betulinic acid 472-15-1
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BCN5870
Sulfocostunolide B 1059671-65-6
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BCN5830
Sulfocostunolide A 1016983-51-9
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BCN3508
1beta-Hydroxyalantolactone 68776-47-6
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