Hedyotis diffusa is a kind of herb used in traditional Chinese medicine. It is sometimes combined with Siraitia grosvenorii to make hot drinks like Lohoguo of Guongsei or Luohanguo Pearl and Sheshecao Beverage.  Hedyotis Diffusa Willd has been used as a major component in several Chinese medicine formulations for the clinical treatment of colorectal cancer. Wild Hedyotis diffusa can be found in China, Japan, and Nepal. It is slender herbs, annual, ascending to procumbent, to 50 cm tall; stems slightly flattened to terete or young stems sometimes 4-angled, sparsely to densely puberulent, scaberulous, or glabrescent to glabrous, similarly glabrous or pubescent on angles and to sides. Three new iridoid glucosides, 6-O-p-coumaroyl, 6-O-p-methoxycinnamoyl and 6-O-feruloyl ester of scandoside methyl ester, have been isolated along with a known glucoside, asperuloside from the aerial parts of Hedyotis diffusa Willd.