Deacetylasperulosidic acidCAS# 14259-55-3 |
- Scandoside
Catalog No.:BCN3449
CAS No.:18842-99-4
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| Cas No. | 14259-55-3 | SDF | Download SDF |
| PubChem ID | 12315350 | Appearance | Colorless crystals |
| Formula | C16H22O11 | M.Wt | 390.3 |
| Type of Compound | Iridoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in methanol and water | ||
| Chemical Name | (1S,4aS,5S,7aS)-5-hydroxy-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid | ||
| SMILES | C1=C(C2C(C1O)C(=COC2OC3C(C(C(C(O3)CO)O)O)O)C(=O)O)CO | ||
| Standard InChIKey | ZVXWFPTVHBWJOU-YYFGDFGFSA-N | ||
| Standard InChI | InChI=1S/C16H22O11/c17-2-5-1-7(19)10-6(14(23)24)4-25-15(9(5)10)27-16-13(22)12(21)11(20)8(3-18)26-16/h1,4,7-13,15-22H,2-3H2,(H,23,24)/t7-,8+,9+,10-,11+,12-,13+,15-,16-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Deacetylasperulosidic acid may increase catalase activity. 2. Deacetylasperulosidic acid inhibits the reduction of ear swelling, and also cancels the suppression of IL-2 production along with the activation of natural killer cells in the same manner as that of Noni-ext. |
| Targets | IL Receptor |
Deacetylasperulosidic acid Dilution Calculator
Deacetylasperulosidic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5621 mL | 12.8107 mL | 25.6213 mL | 51.2426 mL | 64.0533 mL |
| 5 mM | 0.5124 mL | 2.5621 mL | 5.1243 mL | 10.2485 mL | 12.8107 mL |
| 10 mM | 0.2562 mL | 1.2811 mL | 2.5621 mL | 5.1243 mL | 6.4053 mL |
| 50 mM | 0.0512 mL | 0.2562 mL | 0.5124 mL | 1.0249 mL | 1.2811 mL |
| 100 mM | 0.0256 mL | 0.1281 mL | 0.2562 mL | 0.5124 mL | 0.6405 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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In vivo antioxidant activity of deacetylasperulosidic Acid in noni.[Pubmed:24371540]
J Anal Methods Chem. 2013;2013:804504.
Deacetylasperulosidic acid (DAA) is a major phytochemical constituent of Morinda citrifolia (noni) fruit. Noni juice has demonstrated antioxidant activity in vivo and in human trials. To evaluate the role of DAA in this antioxidant activity, Wistar rats were fed 0 (control group), 15, 30, or 60 mg/kg body weight per day for 7 days. Afterwards, serum malondialdehyde concentration and superoxide dismutase and glutathione peroxidase activities were measured and compared among groups. A dose-dependent reduction in malondialdehyde was evident as well as a dose-dependent increase in superoxide dismutase activity. DAA ingestion did not influence serum glutathione peroxidase activity. These results suggest that DAA contributes to the antioxidant activity of noni juice by increasing superoxide dismutase activity. The fact that malondialdehyde concentrations declined with increased DAA dose, despite the lack of glutathione peroxidase-inducing activity, suggests that DAA may also increase catalase activity. It has been previously reported that noni juice increases catalase activity in vivo but additional research is required to confirm the effect of DAA on catalase. Even so, the current findings do explain a possible mechanism of action for the antioxidant properties of noni juice that have been observed in human clinical trials.
Activation of cell-mediated immunity by Morinda citrifolia fruit extract and its constituents.[Pubmed:24868850]
Nat Prod Commun. 2014 Apr;9(4):445-50.
Morinda citrifolia, commonly known as noni, is a traditional natural medicine in French Polynesia and Hawaii. Functional foods derived from M. citrifolia fruit have been marketed to help prevent diseases and promote good health. The objective of this study was to assess the effects of M. citrifolia fruit on cell-mediated immunity. In the picryl chloride-induced contact dermatitis test, M. citrifolia fruit extract (Noni-ext) inhibited the suppression of cell-mediated immunity by immunosuppressive substances isolated from freeze-dried ascites of Ehrlich carcinoma-bearing mice (EC-sup). In addition, Noni-ext inhibited reduction of IL-2 production in EC-sup-treated mice and activated natural killer cells in normal mice. These results suggest that Noni-ext has multiple effects on the recovery of cell-mediated immunity. Furthermore, we investigated the active principles of Noni-ext and identified an iridoid glycoside, Deacetylasperulosidic acid. Oral administration of Deacetylasperulosidic acid inhibited the reduction of ear swelling, and also cancelled the suppression of IL-2 production along with the activation of natural killer cells in the same manner as that of Noni-ext.
