Glyasperin D

CAS# 142561-10-2

Glyasperin D

Catalog No. BCN6836----Order now to get a substantial discount!

Product Name & Size Price Stock
Glyasperin D: 5mg $828 In Stock
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Quality Control of Glyasperin D

Number of papers citing our products

Chemical structure

Glyasperin D

3D structure

Chemical Properties of Glyasperin D

Cas No. 142561-10-2 SDF Download SDF
PubChem ID 480860 Appearance Powder
Formula C22H26O5 M.Wt 370.44
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-[(3R)-5,7-dimethoxy-6-(3-methylbut-2-enyl)-3,4-dihydro-2H-chromen-3-yl]benzene-1,3-diol
SMILES CC(=CCC1=C(C=C2C(=C1OC)CC(CO2)C3=C(C=C(C=C3)O)O)OC)C
Standard InChIKey DDMAUIOCNQXFHL-AWEZNQCLSA-N
Standard InChI InChI=1S/C22H26O5/c1-13(2)5-7-17-20(25-3)11-21-18(22(17)26-4)9-14(12-27-21)16-8-6-15(23)10-19(16)24/h5-6,8,10-11,14,23-24H,7,9,12H2,1-4H3/t14-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Glyasperin D

The roots of Glycyrrhiza aspera Pall.

Biological Activity of Glyasperin D

Description1. Glyasperin D possesses weak anti-Helicobacter pylori activity.
TargetsAntifection

Glyasperin D Dilution Calculator

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Glyasperin D Molarity Calculator

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Preparing Stock Solutions of Glyasperin D

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6995 mL 13.4975 mL 26.9949 mL 53.9898 mL 67.4873 mL
5 mM 0.5399 mL 2.6995 mL 5.399 mL 10.798 mL 13.4975 mL
10 mM 0.2699 mL 1.3497 mL 2.6995 mL 5.399 mL 6.7487 mL
50 mM 0.054 mL 0.2699 mL 0.5399 mL 1.0798 mL 1.3497 mL
100 mM 0.027 mL 0.135 mL 0.2699 mL 0.5399 mL 0.6749 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Glyasperin D

Anti-Helicobacter pylori flavonoids from licorice extract.[Pubmed:12127165]

Life Sci. 2002 Aug 9;71(12):1449-63.

Licorice is the most used crude drug in Kampo medicines (traditional Chinese medicines modified in Japan). The extract of the medicinal plant is also used as the basis of anti-ulcer medicines for treatment of peptic ulcer. Among the chemical constituents of the plant, glabridin and glabrene (components of Glycyrrhiza glabra), licochalcone A (G. inflata), licoricidin and licoisoflavone B (G. uralensis) exhibited inhibitory activity against the growth of Helicobacter pylori in vitro. These flavonoids also showed anti-H. pylori activity against a clarithromycin (CLAR) and amoxicillin (AMOX)-resistant strain. We also investigated the methanol extract of G. uralensis. From the extract, three new isoflavonoids (3-arylcoumarin, pterocarpan, and isoflavan) with a pyran ring, gancaonols A[bond]C, were isolated together with 15 known flavonoids. Among these compounds, vestitol, licoricone, 1-methoxyphaseollidin and gancaonol C exhibited anti-H. pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. Glycyrin, formononetin, isolicoflavonol, Glyasperin D, 6,8-diprenylorobol, gancaonin I, dihydrolicoisoflavone A, and gancaonol B possessed weaker anti-H. pylori activity. These compounds may be useful chemopreventive agents for peptic ulcer or gastric cancer in H. pylori-infected individuals.

Description

Glyasperin D is a flavonoid isolated from Glycyrrhiza uralensis, and possesses weaker anti-Helicobacter pylori activity.

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