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Stem Cell

Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells. They are found in multicellular organisms. In mammals, there are two broad types of stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found in various tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing adult tissues. In a developing embryo, stem cells can differentiate into all the specialized cells—ectoderm, endoderm and mesoderm but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues.

Products for Stem Cell

Cat.No. Product Name Information
BCC5441 RU-SKI 43 RU-SKI 43 is a potent and selective Hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. RU-SKI 43 reduces Gli-1 activation through Smoothened-independent non-canonical signaling and decreases Akt and mTOR pathway activity. RU-SKI 43 has anti-cancer activity.
BCC7790 Cardiogenol C hydrochloride Cardiogenol C hydrochloride is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM). Cardiogenol C hydrochloride also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C hydrochloride is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models.
BCC1573 FH535 FH535 is an inhibitor of Wnt/β-catenin and PPAR, with anti-tumor activities.
BCC5154 PF-04449913 Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM.
BCC3628 KY 02111 KY02111 is a small molecule which can promote differentiation of hPSCs to cardiomyocytes.
BCC5507 WAY-262611 WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate with an EC50 of 0.63 μM in TCF-Luciferase assay.
BCC5102 IWR-1-endo IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
BCC7823 exo-IWR 1
BCC5487 IM-12 IM-12 is an inhibitor of GSK-3β, with an IC50 of 53 nM, and also enhances Wnt signalling.
BCC6099 IDE 2
BCC7704 PNU 74654 PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell.
BCC7841 IDE 1 IDE1 is an inducer of definitive endoderm 1.
BCC5614 CKI 7 dihydrochloride
BCC6254 SMANT hydrochloride
BCC7798 TCS 2210
BCC1693 LDE225 Diphosphate Erismodegib diphosphate (Sonidegib diphosphate) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.
BCC6258 CCT 031374 hydrobromide
BCC3965 Wnt-C59 Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.
BCC5103 LGK-974 LGK974 (WNT974) is an orally bioavailable and specific Porcupine (PORCN) inhibitor with an IC50 of 0.1 nM.
BCC3935 LY2940680 Taladegib (LY2940680) is an antagonist of the smoothened receptor.
BCC6386 GSK503 GSK503 is a potent and specific inhibitor of EZH2 methyltransferase with Kiapp values of 3 to 27 nM.
BCC1604 GSK126 GSK126 (GSK2816126A) is a potent, highly selective inhibitor of EZH2 methyltransferase with an IC50 of 9.9 nM.
BCC1607 GSK343 GSK343 is a highly potent and selective EZH2 inhibitor with an IC50 of 4 nM.
BCC3838 PF-5274857 PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.
BCC3987 ML 239 ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.
BCC4044 EI1 EI1 (KB-145943) is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.
BCC5101 IWP-L6 IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC50 of 0.5 nM.
BCC5396 CPI-169 CPI-169 racemate is the racemate of CPI-169. CPI-169 is a novel and potent EZH2 inhibitor.
BCC5509 BMS-983970 BMS-983970 is an oral pan-Notch inhibitor for the treatment of multiplecancers.
BCC5591 Z-Ile-Leu-aldehyde Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch.
BCC6487 CCT251545 CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with an IC50 of 5 nM in 7dF3 cells.
BCC6486 Windorphen
BCC6329 GSA 10
BCC1508 D4476 D4476 is a potent, selective and cell-permeable inhibitor of casein kinase 1(CK1) with an IC50 value of 0.3 μM in vitro.
BCC3939 Ciliobrevin A Ciliobrevin A is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM.
BCC7136 U 18666A U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor.
BCC3941 SANT-1 SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively.
BCC5110 FLI-06 Inhibitor of Notch signaling,FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.
BCC3936 JK 184 JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells.
BCC6334 Shz 1
BCC3937 SANT-2
BCC7950 MRT 10
BCC7965 IQ 1 IQ 1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on.
BCC3940 AY 9944 dihydrochloride AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol.
BCC5603 C34 TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.
BCC6251 JW 67
BCN2964 Cyclopamine Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay.
BCC3981 SW033291 SW033291 is a potent and high-affinity inhibitor of 15-PGDH with a Ki of 0.1 nM. SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues. SW033291 also promotes tissue regeneration.
BCN2975 Jervine Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum album. Jervine has anti-inflammatory and antioxidant properties.
BCC6211 Kartogenin Kartogenin is an inducer of differentiation of human mesenchymal stem cells into chondrocytes.
BCC3641 Purmorphamine Purmorphamine (Shh Signaling Antagonist VI) is a smoothened receptor agonist with an EC50 of 1 μM.
BCC1617 HhAntag HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway; antitumor agent.
BCC1090 GANT61 GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.
BCC7937 20(S)-Hydroxycholesterol 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells.
BCC1916 Salinomycin Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin (Procoxacin) shows selective activity against human cancer stem cells.
BCC6199 Cardionogen 1
BCC3938 HPI 1 Inhibits Hedgehog signaling
BCC4246 LH846 LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively.
BCC5401 iCRT 14 iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive STF16 luciferase.
BCC1665 IWP-2 IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ.
BCC5602 IWP 4 IWP-4 is a small molecule Wnt inhibitor with an IC50 of 25 nM.
BCC6181 ISX 9 ISX-9 is a small molecule inducer of adult neural stem cell differentiation.
BCC3632 ICG 001 ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
BCC1285 GDC-0449 (Vismodegib) Vismodegib (GDC-0449) is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM. It also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively.
BCC6390 SAG SAG is a potent Smo receptor agonist which activates the Hedgehog signaling pathway with a Kd of 59 nM.
BCC7738 Neurodazine Neurodazine is an imidazole-based small molecule, serve as a promoter of neurogenesisin pluripotent cells. Neurodazine promotes neurogenesis by activating Wnt and Shh signaling pathways. Neurodazine selectively suppresses astrocyte differentiation of P19 cells.
BCC7648 QS 11 ARFGAP1 inhibitor; modulates Wnt signaling pathway,QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor.
BCC1856 PF-670462 PF-670462 is a potent and selective inhibitor of casein kinase (CK1ε and CK1δ), with IC50s of 7.7 nM and 14 nM, respectively.
BCC5066 LDE225 (NVP-LDE225,Erismodegib) Erismodegib (Sonidegib) is a potent and selective Smoothened (Smo) antagonist with IC50s of 1.3 nM and 2.5 nM for mouse and human Smo, respectively.