Products for Wnt/β-catenin
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BCC7790
Cardiogenol C hydrochloride
Cardiogenol C hydrochloride is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM). Cardiogenol C hydrochloride also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C hydrochloride is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models.
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BCC1573
FH535
FH535 is an inhibitor of Wnt/β-catenin and PPAR, with anti-tumor activities.
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BCC3628
KY 02111
KY02111 is a small molecule which can promote differentiation of hPSCs to cardiomyocytes.
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BCC5507
WAY-262611
WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate with an EC50 of 0.63 μM in TCF-Luciferase assay.
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BCC5102
IWR-1-endo
IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
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BCC7823
exo-IWR 1
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BCC6099
IDE 2
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BCC7704
PNU 74654
PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell.
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BCC7841
IDE 1
IDE1 is an inducer of definitive endoderm 1.
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BCC7798
TCS 2210
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BCC6258
CCT 031374 hydrobromide
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BCC3965
Wnt-C59
Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.
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BCC5103
LGK-974
LGK974 (WNT974) is an orally bioavailable and specific Porcupine (PORCN) inhibitor with an IC50 of 0.1 nM.
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BCC5101
IWP-L6
IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC50 of 0.5 nM.
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BCC6487
CCT251545
CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with an IC50 of 5 nM in 7dF3 cells.
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BCC6486
Windorphen
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BCC6334
Shz 1
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BCC7965
IQ 1
IQ 1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on.
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BCC6251
JW 67
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BCC6211
Kartogenin
Kartogenin is an inducer of differentiation of human mesenchymal stem cells into chondrocytes.
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BCC1916
Salinomycin
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin (Procoxacin) shows selective activity against human cancer stem cells.
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BCC6199
Cardionogen 1
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BCC5401
iCRT 14
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive STF16 luciferase.
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BCC1665
IWP-2
IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ.
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BCC5602
IWP 4
IWP-4 is a small molecule Wnt inhibitor with an IC50 of 25 nM.
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BCC6181
ISX 9
ISX-9 is a small molecule inducer of adult neural stem cell differentiation.
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BCC3632
ICG 001
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
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BCC7738
Neurodazine
Neurodazine is an imidazole-based small molecule, serve as a promoter of neurogenesisin pluripotent cells. Neurodazine promotes neurogenesis by activating Wnt and Shh signaling pathways. Neurodazine selectively suppresses astrocyte differentiation of P19 cells.
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BCC7648
QS 11
ARFGAP1 inhibitor; modulates Wnt signaling pathway,QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor.
