Cardiogenol C hydrochlorideInduces cardiomyocyte differentiation in ESCs CAS# 1049741-55-0 |
- GAP-134
Catalog No.:BCC1588
CAS No.:943134-39-2
Quality Control & MSDS
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| Cas No. | 1049741-55-0 | SDF | Download SDF |
| PubChem ID | 16078958 | Appearance | Powder |
| Formula | C13H17ClN4O2 | M.Wt | 296.75 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in water and to 100 mM in DMSO | ||
| Chemical Name | 2-[[2-(4-methoxyanilino)pyrimidin-4-yl]amino]ethanol;hydrochloride | ||
| SMILES | COC1=CC=C(C=C1)NC2=NC=CC(=N2)NCCO.Cl | ||
| Standard InChIKey | QQAHYSZVJLHCNA-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C13H16N4O2.ClH/c1-19-11-4-2-10(3-5-11)16-13-15-7-6-12(17-13)14-8-9-18;/h2-7,18H,8-9H2,1H3,(H2,14,15,16,17);1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Induces differentiation of mouse embryonic stem cells (ESCs) into cardiomyocytes (EC50 = 100 nM). |
Cardiogenol C hydrochloride Dilution Calculator
Cardiogenol C hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3698 mL | 16.8492 mL | 33.6984 mL | 67.3968 mL | 84.246 mL |
| 5 mM | 0.674 mL | 3.3698 mL | 6.7397 mL | 13.4794 mL | 16.8492 mL |
| 10 mM | 0.337 mL | 1.6849 mL | 3.3698 mL | 6.7397 mL | 8.4246 mL |
| 50 mM | 0.0674 mL | 0.337 mL | 0.674 mL | 1.3479 mL | 1.6849 mL |
| 100 mM | 0.0337 mL | 0.1685 mL | 0.337 mL | 0.674 mL | 0.8425 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Cardiogenol C hydrochloride is a cell-permeable pyrimidine compound which potently induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM). IC50 value: 100 nM (EC50) Target: in vitro: Cardiogenol C hydrochloride is a cardiomyogenesis inducer in embryonic stem cells. Cardiogenol C induces the differentiation of myosin heavy chain-positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 μM; about 90% of embryonic stem cells treated with 0.25 μM of Cardiogenol C express the cardiac muscle cell specific transcription factors GATA-4, MEF2, and Nkx2.5 and display the characteristic beating behavior of differentiated cardiomyocytes. Cardiogenol C (a diaminopyrimidine) induces cardiac differentiation in P19 and in P19Cl6 cells. [1] Cardiogenol C could activate Wnt/β-catenin signaling to induce cardiogenesis. Cardiogenol C-treatment significantly decreased HBPCs proliferation. Cardiogenol C was able to induce HBPCs to transdifferentiate into cardiomyocyte-like cells.[2]
References:
[1]. Jasmin, et al. Chemical induction of cardiac differentiation in p19 embryonal carcinoma stem cells. Stem Cells Dev. 2010 Mar;19(3):403-412.
[2]. Yau WW, et al. Cardiogenol C can induce Mouse Hair Bulge Progenitor Cells to Transdifferentiate into Cardiomyocyte-like Cells. Proteome Sci. 2011 Jan 19;9(1):3.
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Small molecules that induce cardiomyogenesis in embryonic stem cells.[Pubmed:14871063]
J Am Chem Soc. 2004 Feb 18;126(6):1590-1.
A phenotypic cell-based screen of a large combinatorial chemical library led to the identification of a class of diaminopyrimidine compounds (cardiogenol A-D) which can selectively and efficiently induce mouse embryonic stem cells (ESCs) to differentiate into cardiomyocytes. ESC-derived cardiomyocytes were shown to express multiple cardiac muscle markers, including myosin heavy chain, GATA-4, MEF2, and Nkx2.5, and spontaneously form beating regions. Such small molecules will serve as useful chemical probes to study cardiac muscle differentiation and may ultimately facilitate the therapeutic application of ESCs for cardiac repair.
