Ro 51Potent P2X3, P2X2/3 antagonist CAS# 1050670-85-3 |
- BS-181
Catalog No.:BCC1439
CAS No.:1092443-52-1
- WHI-P180 hydrochloride
Catalog No.:BCC4243
CAS No.:153437-55-9
- SNS-032 (BMS-387032)
Catalog No.:BCC1152
CAS No.:345627-80-7
- Dinaciclib (SCH727965)
Catalog No.:BCC3765
CAS No.:779353-01-4
- RGB-286638
Catalog No.:BCC5519
CAS No.:784210-87-3
- AT7519 Hydrochloride
Catalog No.:BCC1376
CAS No.:902135-91-5
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 1050670-85-3 | SDF | Download SDF |
PubChem ID | 24883277 | Appearance | Powder |
Formula | C17H23IN4O4 | M.Wt | 474.29 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol | ||
Chemical Name | 2-[[4-amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propane-1,3-diol | ||
SMILES | CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)NC(CO)CO)I)OC | ||
Standard InChIKey | PAYROHWFGZADBR-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C17H23IN4O4/c1-9(2)11-4-14(25-3)12(18)5-13(11)26-15-6-20-17(22-16(15)19)21-10(7-23)8-24/h4-6,9-10,23-24H,7-8H2,1-3H3,(H3,19,20,21,22) | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Potent, dual P2X3 and P2X2/3 antagonist (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively). Selective for P2X3 and P2X2/3 over other P2X receptors (IC50 values are > 10 μM for P2X1, P2X2, P2X4, P2X5, and P2X7). Cell permeable. |
Ro 51 Dilution Calculator
Ro 51 Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.1084 mL | 10.5421 mL | 21.0841 mL | 42.1683 mL | 52.7104 mL |
5 mM | 0.4217 mL | 2.1084 mL | 4.2168 mL | 8.4337 mL | 10.5421 mL |
10 mM | 0.2108 mL | 1.0542 mL | 2.1084 mL | 4.2168 mL | 5.271 mL |
50 mM | 0.0422 mL | 0.2108 mL | 0.4217 mL | 0.8434 mL | 1.0542 mL |
100 mM | 0.0211 mL | 0.1054 mL | 0.2108 mL | 0.4217 mL | 0.5271 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- 1-Ketoaethiopinone
Catalog No.:BCN3219
CAS No.:105062-36-0
- GPR120 modulator 2
Catalog No.:BCC1600
CAS No.:1050506-87-0
- GPR120 modulator 1
Catalog No.:BCC1599
CAS No.:1050506-75-6
- AST-1306 TsOH
Catalog No.:BCC4043
CAS No.:1050500-29-2
- Pallidol
Catalog No.:BCN3306
CAS No.:105037-88-5
- Ascomycin(FK 520)
Catalog No.:BCC1370
CAS No.:104987-12-4
- Tacrolimus (FK506)
Catalog No.:BCC4952
CAS No.:104987-11-3
- 3-Acetoxy-4,7(11)-cadinadien-8-one
Catalog No.:BCN5865
CAS No.:104975-02-2
- PS 1145 dihydrochloride
Catalog No.:BCC7949
CAS No.:1049743-58-9
- Cardiogenol C hydrochloride
Catalog No.:BCC7790
CAS No.:1049741-55-0
- A 331440 dihydrochloride
Catalog No.:BCC7963
CAS No.:1049740-32-0
- Naspm trihydrochloride
Catalog No.:BCC7476
CAS No.:1049731-36-3
- Moellendorffilin
Catalog No.:BCN3546
CAS No.:105099-87-4
- Ligucyperonol
Catalog No.:BCN6638
CAS No.:105108-20-1
- GSK744 (S/GSK1265744)
Catalog No.:BCC3888
CAS No.:1051375-10-0
- S/GSK1349572
Catalog No.:BCC2138
CAS No.:1051375-16-6
- GSK1349572 sodiuM salt
Catalog No.:BCC6407
CAS No.:1051375-19-9
- AC 264613
Catalog No.:BCC3952
CAS No.:1051487-82-1
- 9-Oxoageraphorone
Catalog No.:BCN5866
CAS No.:105181-06-4
- Q94 hydrochloride
Catalog No.:BCC6281
CAS No.:1052076-77-3
- PSB 0739
Catalog No.:BCC6095
CAS No.:1052087-90-7
- PSB 06126
Catalog No.:BCC7417
CAS No.:1052089-16-3
- WEB 2086
Catalog No.:BCC7335
CAS No.:105219-56-5
- Virosine B
Catalog No.:BCN6742
CAS No.:1052228-70-2
Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain.[Pubmed:19231178]
Bioorg Med Chem Lett. 2009 Mar 15;19(6):1632-5.
The purinoceptor subtypes P2X(3) and P2X(2/3) have been shown to play a pivotal role in models of various pain conditions. Identification of a potent and selective dual P2X(3)/P2X(2/3) diaminopyrimidine antagonist RO-4 prompted subsequent optimization of the template. This paper describes the SAR and optimization of the diaminopyrimidine ring and particularly the substitution of the 2-amino group. The discovery of the highly potent and drug-like dual P2X(3)/P2X(2/3) antagonist RO-51 is presented.