P2X purinergic receptor - Membrane Transporter/Ion Channel

Cat.No. Product Name Information

BCC6918 2-Methylthioadenosine triphosphate tetrasodium salt

BCC7015 PPNDS PPNDS

BCC7548 RO-3 RO-3

BCC7367 NF 157 NF157 is a highly selective nanomolar P2Y11 antagonist with a pKi of 7.35. The IC50s are 463 nM, 1811 µM, 170 µM for P2Y11 (Ki=44.3 nM), P2Y1 (Ki=187 µM), P2Y2 (Ki=28.9 µM), respectively. NF157, significantly reduces expression of metalloproteinase (MMP)-3, MMP-13, can be used in the treatment of osteoarthritis (OA). NF 157

BCC6985 NF 023 NF 023

BCC6157 Ro 51 Ro 51

BCC7404 NF 110 NF 110

BCC6198 A 804598 A-804598 is a CNS penetrant, competitive and selective P2X7 receptor antagonist with IC50s of 9 nM, 10 nM and 11 nM for mouse, rat and human P2X7 receptors, respectively.

BCC7643 BzATP triethylammonium salt

BCC1682 KN-92 phosphate KN-92 phosphate is an inactive derivative of KN-93.

BCC3602 KN-62 KN-62 is a selective and potent inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with IC50 of 0.9 μM, KN-62 also displays noncompetitive antagonism at P2X7 receptors in HEK293 cells, with an IC50 value of approximately 15 nM. KN-62

BCC7079 Suramin hexasodium salt Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM). Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM). Suramin sodium salt is an antitrypanosomal, anti-neoplastic and anti-angiogenic agent. Suramin hexasodium salt

BCC7276 Ro 0437626

BCC1683 KN-93 CaM kinase II inhibitor; also K+ channel blocker (KV),KN-93 is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II, with Ki of 370 nM. KN-93

BCC6333 Purotoxin 1

BCC6966 MRS 2219

BCC1681 KN-92 hydrochloride KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).

BCC6725 PPADS tetrasodium salt PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca²⁺exchanger in guinea pig airway smooth muscle. PPADS tetrasodium salt

BCC6964 NF 279 NF 279

BCC6749 iso-PPADS tetrasodium salt P2X antagonist

BCC7646 AZ 11645373 Potent and selective human P2X7 antagonist

BCC1320 A-317491 A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors.

BCC6005 AZ 10606120 dihydrochloride AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth. AZ 10606120 dihydrochloride

BCC7373 TNP-ATP triethylammonium salt

BCC7043 NF 449 Highly selective P2X1 antagonist NF 449

BCC1251 Ivermectin Ivermectin (MK-933) is a broad-spectrum anti-parasite medication used in humans most commonly to treat nematode infections such as onchocerciasis, as well as scabies and lice. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import.

BCC7717 5-BDBD 5-BDBD

BCC6155 TC-P 262

BCC1317 A 438079 hydrochloride A 438079 (hydrochloride) is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

BCC1316 A 438079 A 438079 is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

BCC7855 ATPγS tetralithium salt

Products for P2X purinergic receptor