TNP-ATP triethylammonium saltPotent, selective P2X antagonist CAS# 61368-63-6 |
- Valproic acid sodium salt (Sodium valproate)
Catalog No.:BCC2156
CAS No.:1069-66-5
- Vorinostat (SAHA, MK0683)
Catalog No.:BCC2145
CAS No.:149647-78-9
- Resminostat (RAS2410)
Catalog No.:BCC2165
CAS No.:864814-88-0
- PCI-34051
Catalog No.:BCC2148
CAS No.:950762-95-5
- Droxinostat
Catalog No.:BCC2157
CAS No.:99873-43-5
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 61368-63-6 | SDF | Download SDF |
| PubChem ID | 90474108 | Appearance | Powder |
| Formula | C40H77N12O19P3 | M.Wt | 1123.04 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) | ||
| Chemical Name | 2',3'-O-(2,4,6-Trinitrophenyl)adenosi | ||
| SMILES | CCN(CC)CC.CCN(CC)CC.CCN(CC)CC.CCN(CC)CC.C1=C(C=C(C2(C1[N+](=O)[O-])OC3C(OC(C3O2)N4C=NC5=C4N=CN=C5N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[N+](=O)[O-])[N+](=O)[O-] | ||
| Standard InChIKey | SWLXZTUOMCLGJI-UHFFFAOYSA-M | ||
| Standard InChI | InChI=1S/C16H13N8O19P3/c17-13-10-14(19-4-18-13)21(5-20-10)15-12-11(7(39-15)3-38-45(34,35)43-46(36,37)42-44(31,32)33)40-16(41-12)8(23(27)28)1-6(22(25)26)2-9(16)24(29)30/h1-2,4-5,8,10,17H,3H2,(H,34,35)(H,36,37)(H2,31,32,33)/p-1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | High affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1, P2X3 and P2X2/3 receptors with IC50 values of 6, 0.9, and 7 nM respectively. Displays 1000-fold selectivity over P2X2, P2X4 and P2X7. |
TNP-ATP triethylammonium salt Dilution Calculator
TNP-ATP triethylammonium salt Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 0.8904 mL | 4.4522 mL | 8.9044 mL | 17.8088 mL | 22.261 mL |
| 5 mM | 0.1781 mL | 0.8904 mL | 1.7809 mL | 3.5618 mL | 4.4522 mL |
| 10 mM | 0.089 mL | 0.4452 mL | 0.8904 mL | 1.7809 mL | 2.2261 mL |
| 50 mM | 0.0178 mL | 0.089 mL | 0.1781 mL | 0.3562 mL | 0.4452 mL |
| 100 mM | 0.0089 mL | 0.0445 mL | 0.089 mL | 0.1781 mL | 0.2226 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- VU 0364770
Catalog No.:BCC4597
CAS No.:61350-00-3
- Boc-D-Glu-OH
Catalog No.:BCC2606
CAS No.:61348-28-6
- Boc-D-Gln-OH
Catalog No.:BCC2607
CAS No.:61348-28-5
- Amoxicillin trihydrate
Catalog No.:BCC5168
CAS No.:61336-70-7
- Neoschaftoside
Catalog No.:BCN3053
CAS No.:61328-41-4
- Sulconazole Nitrate
Catalog No.:BCC4853
CAS No.:61318-91-0
- Boc-D-Arg(Tos)-OH
Catalog No.:BCC3070
CAS No.:61315-61-5
- Isoacteoside
Catalog No.:BCN4137
CAS No.:61303-13-7
- Schisandrin C
Catalog No.:BCN1198
CAS No.:61301-33-5
- 2-Aminoacetophenone
Catalog No.:BCC8546
CAS No.:613-89-8
- 2-(Phenylmethoxy)-naphthalene
Catalog No.:BCC8485
CAS No.:613-62-7
- AKT inhibitor VIII
Catalog No.:BCC1334
CAS No.:612847-09-3
- erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether
Catalog No.:BCN7024
CAS No.:613684-55-2
- Griffonilide
Catalog No.:BCN1271
CAS No.:61371-55-9
- Rifapentine
Catalog No.:BCC4937
CAS No.:61379-65-5
- Trigonelline hydrochloride
Catalog No.:BCN1050
CAS No.:6138-41-6
- Naginata ketone
Catalog No.:BCN7801
CAS No.:6138-88-1
- 3-Amino-3-phenylpropionic acid
Catalog No.:BCC8609
CAS No.:614-19-7
- Procainamide HCl
Catalog No.:BCC5492
CAS No.:614-39-1
- 2-Hydroxycinnamic acid
Catalog No.:BCN5039
CAS No.:614-60-8
- 2,4-Dihydroxyphenylacetic acid
Catalog No.:BCN4139
CAS No.:614-82-4
- Rolipram
Catalog No.:BCC2282
CAS No.:61413-54-5
- Carmofur
Catalog No.:BCC1214
CAS No.:61422-45-5
- 2-Amino-3-Formylchromone
Catalog No.:BCC8526
CAS No.:61424-76-8
Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors.[Pubmed:9614197]
Mol Pharmacol. 1998 Jun;53(6):969-73.
There are currently seven P2X receptor subunits (P2X1-7) defined by molecular cloning. The functional identification of these receptors has relied primarily on the potency of alpha,beta-methylene-ATP relative to that of ATP and on the kinetics of receptor desensitization. In the present experiments we found that the 2', 3'-O-(2,4,6-trinitrophenyl)-substituted analogs of ATP are selective and potent antagonists at some but not all P2X receptors. The trinitrophenyl analogs of ATP, ADP, AMP, and GTP produced a reversible inhibition of ATP-evoked currents in human embryonic kidney 293 cells expressing P2X1 receptors, P2X3 receptors, or both P2X2 and P2X3 (heteromeric) receptors; IC50 values were close to 1 nM. These compounds were at least 1000-fold less effective in blocking currents in cells expressing P2X2, P2X4, or P2X7 receptors (P2X5 and P2X6 not tested). GTP, 2,4,6-trinitrophenol, and the 2',3'-trinitrophenyl analog of adenosine (0.1-10 microM) had no effect. Thus, we have identified a structural motif that confers antagonist action at P2X receptors that contain P2X1 or P2X3 subunits (the alpha,beta-methylene-ATP-sensitive subclass).
2',3'-O-(2,4,6- trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP)--a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels.[Pubmed:9723959]
Br J Pharmacol. 1998 Aug;124(7):1463-6.
1. P2X receptor activation by alpha,beta-meATP evoked inward currents in acutely dissociated rat mesenteric artery smooth muscle cells and contractions of whole artery rings. 2. The selective P2X1 and P2X3 receptor antagonist TNP-ATP inhibited P2X receptor mediated inward currents in response to 3 microM alpha,beta-meATP (an approximately EC90 concentration) with an IC50 of approximately 2 nM. This provides further evidence that the P2X receptor underlying membrane depolarisation associated with P2X receptor activation can be accounted for by the expression of P2X1 receptors. 3. TNP-ATP inhibited alpha,beta-meATP induced contractions with an IC50 of approximately 30 microM and had non-specific effects on smooth muscle contraction. 4. The reduced potency of TNP-ATP in whole tissue experiments probably reflects the breakdown of TNP-ATP by nucleotidases. Thus, TNP-ATP is of limited use in whole tissue experiments as a P2X receptor antagonist.
