Procainamide HClCAS# 614-39-1 |
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Quality Control & MSDS
3D structure
Package In Stock
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| Cas No. | 614-39-1 | SDF | Download SDF |
| PubChem ID | 66068 | Appearance | Powder |
| Formula | C13H22ClN3O | M.Wt | 271.79 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | H2O : ≥ 50 mg/mL (183.97 mM) DMSO : 50 mg/mL (183.97 mM; Need ultrasonic) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 4-amino-N-[2-(diethylamino)ethyl]benzamide;hydrochloride | ||
| SMILES | CCN(CC)CCNC(=O)C1=CC=C(C=C1)N.Cl | ||
| Standard InChIKey | ABTXGJFUQRCPNH-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C13H21N3O.ClH/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17);1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Procainamide HCl Dilution Calculator
Procainamide HCl Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.6793 mL | 18.3966 mL | 36.7931 mL | 73.5862 mL | 91.9828 mL |
| 5 mM | 0.7359 mL | 3.6793 mL | 7.3586 mL | 14.7172 mL | 18.3966 mL |
| 10 mM | 0.3679 mL | 1.8397 mL | 3.6793 mL | 7.3586 mL | 9.1983 mL |
| 50 mM | 0.0736 mL | 0.3679 mL | 0.7359 mL | 1.4717 mL | 1.8397 mL |
| 100 mM | 0.0368 mL | 0.184 mL | 0.3679 mL | 0.7359 mL | 0.9198 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Procainamide hydrochloride is an anti-arrhythmic agent and is used to treat cardiac arrhythmia; induces rapid block of the batrachotoxin(BTX)-activated sodium channels of the heart muscle and acts as antagonist to long gating closures.
References:
[1]. Zamponi GW, et al. Dual actions of procainamide on batrachotoxin-activated sodium channels: open channel block and prevention of inactivation. Biophys J. 1993 Dec;65(6):2324-34.
[2]. http://en.wikipedia.org/wiki/Procainamid
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Flow injection method for the assay of the anti-arrhythmic procainamide HCl in drug formulations utilizing statistical optimization techniques.[Pubmed:18965675]
Talanta. 1993 May;40(5):623-7.
A flow injection spectrophotometric method for the determination of Procainamide HCl was explored. The method was based on the oxidation of Procainamide HCl with cerium(IV) in sulphuric acid media and subsequent monitoring of the absorbance of the oxidized form of the drug at 480 nm. A sample rate of 250 samples per hour was attained. The procedure was optimized by the Factorial Design at two upper and lower levels of the five parameters sample loop size, flow rate, coil length, sulphuric acid and cerium(IV) concentrations. The latter three indicated high interactions and revealed significance to peak height value therefore optimized by the Super Modified Simplex programme. The optimized FI system with a linear calibration range of 100-600 ppm was found to be adequate and suitable for determination of Procainamide HCl in proprietary drugs. A high degree of accuracy of the results was demonstrated by a statistical comparison with those obtained by the British Pharmacopoeia method of the same batch of drugs.
