Endocrinology and Hormones

Cat.No. Product Name Information

BCC1013 GnRH Associated Peptide (GAP) (1-13), human

BCC7557 GSK 4716 GSK-4716 is a selective ERRβ/γ agonist.

BCC5780 CTOP CTOP

BCC5776 CTAP CTAP

BCC3586 Perindopril Erbumine Perindopril erbumine (Perindopril tert-butylamine salt) is a potent ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease.

BCC7811 PF 998425

BCC1061 Exemestane Exemestane(FCE 24304) is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.

BCC7701 FERb 033

BCC6773 Naltrindole hydrochloride Naltrindole hydrochloride is a highly potent and selective non-peptide δ opioid receptor antagonist with a Ki of 0.02 nM.

BCC7761 Endoxifen Endoxifen Z-isomer is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα).

BCC6751 BRL 52537 hydrochloride

BCC6668 U-54494A hydrochloride

BCC1063 Letrozole Letrozole is an aromatase inhibitor with an IC50 of 1-13 nM.

BCC6614 nor-Binaltorphimine dihydrochloride Norbinaltorphimine dihydrochloride is a potent and selective κ opioid receptor antagonist.

BCC6666 (-)-U-50488 hydrochloride

BCC6656 (+)-U-50488 hydrochloride

BCC6792 ICI 199,441 hydrochloride

BCC6058 G-15 G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM. G-15

BCC5684 Clocinnamox mesylate

BCC7425 Cyprodime hydrochloride

BCC5757 Naloxone benzoylhydrazone Naloxone benzoylhydrazone (NalBzoH) is a mixed agonist/antagonist. Naloxone benzoylhydrazone is a prototypic κ3-opioid receptor agonist, and a partial agonist at the cloned μ and δ opioid receptors, and an antagonist at opioid-like NOP receptors. Naloxone benzoylhydrazone has potently analgesia effect.

BCC4370 Anastrozole Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM.

BCC6782 N-Benzylnaltrindole hydrochloride

BCC6806 ICI 204,448 hydrochloride

BCC5687 SB 205607 dihydrobromide

BCC5683 Naltriben mesylate

BCC6233 Deltorphin I Deltorphin I is a δ-opioid receptor agonist with high affinity and selectivity.

BCC5723 [D-Ala2]-Deltorphin II Deltorphin 2 is a selective peptide agonist for the δ opioid receptor.

BCC1041 Peptide YY(3-36), PYY, human

BCC6090 Oxycodone hydrochloride

BCC1070 AZD3514 AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression. AZD3514

BCC1080 Losartan Potassium (DuP 753) Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC50 of 20 nM.

BCC4368 Aminoglutethimide Aminoglutethimide is an aromatase inhibitor with IC50 of 10 μM.

BCC7083 GR 89696 fumarate

BCC5557 Ospemifene Ospemifene is a selective estrogen for the prevention of postmenopausal osteoporosis with IC50 values of 827nM and 1633nM for ERα and ERβ, respectively.

BCC1081 Fulvestrant Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and apoptosis and has antitumor efficacy.

BCC3796 ODM-201 Darolutamide (ODM-201;BAY-1841788) is a potent androgen receptor (AR) antagonist with an IC50 of 26 nM in in vitro assay. ODM-201

BCC4364 Flutamide Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.

BCC1719 LY2795050 LY2795050 is a novel selective κ-opioid Receptor (KOR) antagonist (IC50=0.72 nM) and has the potential as a PET tracer to image KOR in vivo.

BCC6308 ML 190 ML 190

BCC7224 (R,R)-THC

BCC1349 Alvimopan monohydrate Alvimopan monohydrate (ADL 8-2698 monohydrate) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.

BCC6283 G-36 G-36

BCC2558 Candesartan Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.

BCC5697 Endomorphin-2 Endomorphin 2, a high affinity, highly selective agonist of the μ-opioid receptor, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM.

BCC7088 DPN DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β(ER β) selective ligand. DPN

BCC5954 Diprenorphine

BCC3863 Telmisattan Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

BCC3853 Rosuvastatin Calcium Rosuvastatin Calcium (Rosuvastatin hemicalcium) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

BCC7608 RU 58668

BCC1911 RU 58841 RU 58841 (PSK-3841) is a specific androgen receptor antagonist or anti-androgen. RU 58841 (PSK-3841) has a dramatic effect on hair regrowth.

BCC6799 DIPPA hydrochloride

BCC5798 BW 373U86

BCC1347 Alvimopan Alvimopan(LY 246736; ADL 8-2698) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.

BCC6785 SNC 80 SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment. SNC 80

BCC1295 (Z)-2-decenoic acid (Z)-2-decenoic acid(cis-2-Decenoic acid) is an unsaturated short chain fatty acid that is secreted by P.

BCC1097 Dutasteride Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT.

BCC1783 Naltrexone

BCC4613 Naltrexone HCl Broad spectrum opioid antagonist,Naltrexone HCl is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.

BCC1348 Alvimopan dihydrate Alvimopan dihydrate (ADL 8-2698 dihydrate) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.

BCC7272 ZK 164015

BCC7103 SNC 162 SNC 162

BCC7831 Zearalenone Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts.

BCC6069 TFM-4AS-1

BCC7780 Cl-4AS-1

BCC1296 17 alpha-propionate Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist.

BCC4492 Bazedoxifene HCl Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively.

BCC1411 Bazedoxifene Bazedoxifene (TSE-424) is a selective estrogen receptor modulator (SERM) currently in development for osteoporosis prevention and treatment.

BCC1412 Bazedoxifene acetate Bazedoxifene acetate (TSE-424 acetate) is a third generation selective estrogen receptor modulator (SERM) with IC50s of 26 and 99 nM for ERα and ERβ, respectively.

BCC5672 N-MPPP Hydrochloride

BCC6143 AR-M 1000390 hydrochloride AR-M 1000390 hydrochloride is an exceptionally selective, potent δ opioid receptor agonist with an EC50 of 7.2±0.9 nM for δ agonist potency.

BCC1957 Sobetirome Sobetirome is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC50 of 0.16 μM.

BCC4204 Finasteride acetate Finasteride (acetate) is an orally active testosterone 5-alpha-reductase inhibitor.

BCC6536 EPI-001 EPI-001

BCC3800 JTC-801 JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a Ki value of 8.2 nM. JTC-801

BCC7839 Cyclofenil Cyclofenil is a selective estrogen receptor modulator and an ovulation-inducing agent. Cyclofenil shows an inhibitory effect on dengue virus replication in Vero cells with an EC50

BCC7062 PPT Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%). PPT

BCC4483 Ethynodiol diacetate Ethynodiol diacetate is a steroidal progestin which is used as a hormonal contraceptive, it has relatively little or no potency as an androgen,has significant estrogenic effects.

BCC4477 Estradiol Cypionate Estradiol cypionate is a 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor IC50 value: Target: estrogen receptor Estradiol cypionate is a synthetic ester, is a estrogen.

BCC1292 (E)-2-Decenoic acid (E)-2-Decenoic acid is an interesting fatty acid isolated from royal jelly secretions of honey bees.

BCC1049 Luteinizing Hormone Releasing Hormone (LHRH)

BCC7749 CITCO CITCO, an imidazothiazole derivative, is a selective Constitutive androstane receptor (CAR) agonist. CITCO inhibits growth and expansion of brain tumour stem cells (BTSCs) and has an EC50 of 49 nM over pregnane X receptor (PXR), and no activity on other nuclear receptors. CITCO

BCC1005 Angiotensin 1/2 (1-9)

BCC7054 SDM25N hydrochloride

BCC4380 Loperamide HCl Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist. Loperamide hydrochloride is a selective and competitive

BCC7003 GNTI dihydrochloride

BCC4612 Naloxone HCl Broad spectrum opioid antagonist,Naloxone HCl is an opioid inverse agonist drug used to counter the effects of opiate overdose.

BCC1670 JDTic JDTic is a highly selective antagonist for the κ-opioid receptor; without affecting the μ- or δ-opioid receptors. JDTic

BCC4615 Trimebutine Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects.

BCC1168 Andarine Andarine (S-4) is an investigational selective androgen receptor modulator (SARM) and an active partial agonist.

BCC2280 TAK-700 (Orteronel) TAK-700 (Orteronel) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). Phase 3.

BCC3758 Cyproterone Acetate Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity.

BCC4478 Ethisterone Ethisterone is a progestogen hormone being considered to treat prostate cancer.

BCC7669 WAY 200070 WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM.

BCC1036 Angiotensin 1/2 (1-6) Angiotensin I/II 1-6 contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. Angiotensin I is formed by the action of renin on angiotensinogen. Angiotensin II is produced from angiotensin I. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy. Angiotensin 1/2 (1-6)

BCC4481 Epiandrosterone Epiandrosterone is a steroid hormone with weak androgenic activity.

BCC1004 Angiotensin I (human, mouse, rat) Angiotensin 1 (Human) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE).

BCN2235 Estriol Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells. Estriol

BCN2194 beta-Estradiol Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.

BCC4480 Clomiphene citrate Clomiphene citrate (Clomifene citrate) is a selective estrogen receptor modulator.

Endocrinology and Hormones

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