PF 998425Non-steroidal androgen receptor antagonist CAS# 1076225-27-8 |
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| Cas No. | 1076225-27-8 | SDF | Download SDF |
| PubChem ID | 25093231 | Appearance | Powder |
| Formula | C14H14F3NO | M.Wt | 269.26 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol | ||
| Chemical Name | 4-[(1R,2R)-2-hydroxycyclohexyl]-2-(trifluoromethyl)benzonitrile | ||
| SMILES | C1CCC(C(C1)C2=CC(=C(C=C2)C#N)C(F)(F)F)O | ||
| Standard InChIKey | MENRRRXHFQYXDW-DGCLKSJQSA-N | ||
| Standard InChI | InChI=1S/C14H14F3NO/c15-14(16,17)12-7-9(5-6-10(12)8-18)11-3-1-2-4-13(11)19/h5-7,11,13,19H,1-4H2/t11-,13-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Selective non-steroidal androgen receptor (AR) antagonist (IC50 values are 26 nM and 90 nM in AR binding assays and cellular assays respectively). Displays low affinity for progesterone receptor (IC50 > 10 μM). Active in vivo. |
PF 998425 Dilution Calculator
PF 998425 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.7139 mL | 18.5694 mL | 37.1388 mL | 74.2776 mL | 92.8471 mL |
| 5 mM | 0.7428 mL | 3.7139 mL | 7.4278 mL | 14.8555 mL | 18.5694 mL |
| 10 mM | 0.3714 mL | 1.8569 mL | 3.7139 mL | 7.4278 mL | 9.2847 mL |
| 50 mM | 0.0743 mL | 0.3714 mL | 0.7428 mL | 1.4856 mL | 1.8569 mL |
| 100 mM | 0.0371 mL | 0.1857 mL | 0.3714 mL | 0.7428 mL | 0.9285 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications.[Pubmed:18921992]
J Med Chem. 2008 Nov 13;51(21):7010-4.
4-((1 R,2 R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile [PF-0998425, (-)- 6a] is a novel, nonsteroidal androgen receptor antagonist for sebum control and treatment of androgenetic alopecia. It is potent, selective, and active in vivo. The compound is rapidly metabolized systemically, thereby reducing the risk of unwanted systemic side effects due to its primary pharmacology. (-)- 6a was tested negative in the 3T3 NRU assay, validating our rationale that reduction of conjugation might reduce potential phototoxicity.
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