Immunology/Inflammation
Immunology studies the human body’s defense mechanisms against foreign subjects such as viruses and bacteria. The primary immune system organs are the thymus and bone marrow, both of which produce immune cells. Other organs or tissues such as spleen, lymph nodes and vessels, tonsils, adenoids and skin also participate in our body’s immune defense. The immune system is divided into an innate immune system, which provides immediate but non-specific response to pathogens, and an adaptive immune system, which is mediated by immune cells such as T and B lymphocytes and only responds to foreign subjects that they previously encountered.
Products for Immunology/Inflammation
- Cat.No. Product Name Information
- BCC4065 HPGDS inhibitor 1 HPGDS inhibitor 1 is a novel and selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM.
- BCC2515 Zileuton Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
- BCC6245 Pam3CSK4 Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2.
- BCC7017 MK 886 MK886 is a potent 5-lipoxygenase activating protein inhibitor (FLAP) also a non-competitive inhibitor of PPAR alpha. a potent inhibitor of leukotriene (LT) biosynthesis in intact human polymorphonuclear leukocytes with IC 50 of 2.5 nM. Block the synthessis of leukotrien intact activate leukocyte.
- BCC4216 Zileuton sodium Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of 5-lipoxygenase, exhibiting inflammatory activities.
- BCC1006 Anti-Inflammatory Peptide 1
- BCC7460 RWJ 21757 Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist.
- BCC6319 CU CPT 4a
- BCC6038 BAY-X 1005 Veliflapon (BAY X 1005; DG-031) is an orally active and selective 5-lipoxygenase activating protein (FLAP) inhibitor. Veliflapon inhibits the synthesis of the leukotrienes B4 and C4.
- BCC6735 2-TEDC
- BCC7013 BW-B 70C 5-Lipoxygenase inhibitor
- BCC6320 CU CPT 22 CU-CPT22 is a potent protein complex of toll-like receptor 1 and 2 (TLR1/2) inhibitor, and competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 with a Ki of 0.41 µM. CU-CPT22 blocks Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58 µM.
- BCC4071 HG-9-91-01 HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.
- BCC8060 ML355 ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties.
- BCC1977 TAK-242 Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-R and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases.
- BCC6138 Poly(I:C)
- BCC7504 PD 146176 PD146176 (NSC168807) is a 15-Lipoxygenase (15-LO) inhibitor, which inhibits rabbit reticulocyte 15-LO with a Ki of 197 nM. PD146176 (NSC168807) has a dramatic effect in reducing atherogenesis.
- BCC4943 Suprofen Suprofen (TN-762) is a non-steroidal anti-inflammatory drug (NSAID).
- BCC3781 Flurbiprofen Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.
- BCC1196 Malotilate Malotilate is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase.
- BCC6444 Cyclosporin D Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A. Cyclosporin A is a potent immunosuppressant drug, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc).
- BCC1024 Papain Inhibitor
- BCC6247 Pam2CSK4
- BCC4798 Mesalamine 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
- BCC4197 Imiquimod maleate Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7agonist.
- BCC4196 Imiquimod hydrochloride Imiquimod hydrochloride is an immune response modifier that acts as a toll-like receptor 7agonist.