Immunology/Inflammation
Immunology studies the human body’s defense mechanisms against foreign subjects such as viruses and bacteria. The primary immune system organs are the thymus and bone marrow, both of which produce immune cells. Other organs or tissues such as spleen, lymph nodes and vessels, tonsils, adenoids and skin also participate in our body’s immune defense. The immune system is divided into an innate immune system, which provides immediate but non-specific response to pathogens, and an adaptive immune system, which is mediated by immune cells such as T and B lymphocytes and only responds to foreign subjects that they previously encountered.
Products for Immunology/Inflammation
- Cat.No. Product Name Information
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BCC4065
HPGDS inhibitor 1
HPGDS inhibitor 1 is a novel and selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM.
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BCC2515
Zileuton
Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
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BCC6245
Pam3CSK4
Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2.
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BCC7017
MK 886
MK886 is a potent 5-lipoxygenase activating protein inhibitor (FLAP) also a non-competitive inhibitor of PPAR alpha. a potent inhibitor of leukotriene (LT) biosynthesis in intact human polymorphonuclear leukocytes with IC 50 of 2.5 nM. Block the synthessis of leukotrien intact activate leukocyte.
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BCC4216
Zileuton sodium
Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of 5-lipoxygenase, exhibiting inflammatory activities.
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BCC1006
Anti-Inflammatory Peptide 1
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BCC7460
RWJ 21757
Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist.
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BCC6319
CU CPT 4a
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BCC6038
BAY-X 1005
Veliflapon (BAY X 1005; DG-031) is an orally active and selective 5-lipoxygenase activating protein (FLAP) inhibitor. Veliflapon inhibits the synthesis of the leukotrienes B4 and C4.
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BCC6735
2-TEDC
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BCC7013
BW-B 70C
5-Lipoxygenase inhibitor
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BCC6320
CU CPT 22
CU-CPT22 is a potent protein complex of toll-like receptor 1 and 2 (TLR1/2) inhibitor, and competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 with a Ki of 0.41 µM. CU-CPT22 blocks Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58 µM.
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BCC4071
HG-9-91-01
HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.
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BCC8060
ML355
ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties.
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BCC1977
TAK-242
Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-R and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases.
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BCC6138
Poly(I:C)
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BCC7504
PD 146176
PD146176 (NSC168807) is a 15-Lipoxygenase (15-LO) inhibitor, which inhibits rabbit reticulocyte 15-LO with a Ki of 197 nM. PD146176 (NSC168807) has a dramatic effect in reducing atherogenesis.
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BCC4943
Suprofen
Suprofen (TN-762) is a non-steroidal anti-inflammatory drug (NSAID).
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BCC3781
Flurbiprofen
Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.
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BCC1196
Malotilate
Malotilate is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase.
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BCC6444
Cyclosporin D
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A. Cyclosporin A is a potent immunosuppressant drug, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc).
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BCC1024
Papain Inhibitor
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BCC6247
Pam2CSK4
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BCC4798
Mesalamine
5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
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BCC4197
Imiquimod maleate
Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7agonist.
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BCC4196
Imiquimod hydrochloride
Imiquimod hydrochloride is an immune response modifier that acts as a toll-like receptor 7agonist.