CU CPT 4aSelective TLR3 inhibitor CAS# 1279713-77-7 |
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| Cas No. | 1279713-77-7 | SDF | Download SDF |
| PubChem ID | 53242268 | Appearance | Powder |
| Formula | C18H13ClFNO3S | M.Wt | 377.82 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH | ||
| Chemical Name | (2R)-2-[(3-chloro-6-fluoro-1-benzothiophene-2-carbonyl)amino]-3-phenylpropanoic acid | ||
| SMILES | C1=CC=C(C=C1)CC(C(=O)O)NC(=O)C2=C(C3=C(S2)C=C(C=C3)F)Cl | ||
| Standard InChIKey | IAASQMCXDRISAV-CYBMUJFWSA-N | ||
| Standard InChI | InChI=1S/C18H13ClFNO3S/c19-15-12-7-6-11(20)9-14(12)25-16(15)17(22)21-13(18(23)24)8-10-4-2-1-3-5-10/h1-7,9,13H,8H2,(H,21,22)(H,23,24)/t13-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Selective TLR3 inhibitor (IC50 = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF-α and IL-1β production in whole cells. |
CU CPT 4a Dilution Calculator
CU CPT 4a Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6468 mL | 13.2338 mL | 26.4676 mL | 52.9353 mL | 66.1691 mL |
| 5 mM | 0.5294 mL | 2.6468 mL | 5.2935 mL | 10.5871 mL | 13.2338 mL |
| 10 mM | 0.2647 mL | 1.3234 mL | 2.6468 mL | 5.2935 mL | 6.6169 mL |
| 50 mM | 0.0529 mL | 0.2647 mL | 0.5294 mL | 1.0587 mL | 1.3234 mL |
| 100 mM | 0.0265 mL | 0.1323 mL | 0.2647 mL | 0.5294 mL | 0.6617 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Small-molecule inhibitors of the TLR3/dsRNA complex.[Pubmed:21355588]
J Am Chem Soc. 2011 Mar 23;133(11):3764-7.
The protein-RNA interface has been regarded as "undruggable" despite its importance in many biological processes. The toll-like receptor 3 (TLR3)/double-stranded RNA (dsRNA) complex provides an exciting target for a number of infectious diseases and cancers. We describe the development of a series of small-molecule probes that were shown to be competitive inhibitors of dsRNA binding to TLR3 with high affinity and specificity. In a multitude of assays, compound 4a was profiled as a potent antagonist to TLR3 signaling and also repressed the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-alpha and IL-1beta.
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