Imiquimod maleateImmune response modifier CAS# 896106-16-4 |
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Quality Control & MSDS
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| Cas No. | 896106-16-4 | SDF | Download SDF |
| PubChem ID | 11595577 | Appearance | Powder |
| Formula | C18H20N4O4 | M.Wt | 356.38 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | R 837 maleate | ||
| Solubility | Soluble in DMSO | ||
| Chemical Name | (Z)-but-2-enedioic acid;1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine | ||
| SMILES | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N.C(=CC(=O)O)C(=O)O | ||
| Standard InChIKey | KYQFLNAOJRNEDV-BTJKTKAUSA-N | ||
| Standard InChI | InChI=1S/C14H16N4.C4H4O4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15;5-3(6)1-2-4(7)8/h3-6,8-9H,7H2,1-2H3,(H2,15,17);1-2H,(H,5,6)(H,7,8)/b;2-1- | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7agonist.In Vivo:In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete
cytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α[1]. References: | |||||
Imiquimod maleate Dilution Calculator
Imiquimod maleate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.806 mL | 14.03 mL | 28.0599 mL | 56.1199 mL | 70.1498 mL |
| 5 mM | 0.5612 mL | 2.806 mL | 5.612 mL | 11.224 mL | 14.03 mL |
| 10 mM | 0.2806 mL | 1.403 mL | 2.806 mL | 5.612 mL | 7.015 mL |
| 50 mM | 0.0561 mL | 0.2806 mL | 0.5612 mL | 1.1224 mL | 1.403 mL |
| 100 mM | 0.0281 mL | 0.1403 mL | 0.2806 mL | 0.5612 mL | 0.7015 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.
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Open-label nonrandomized left-right comparison of imiquimod 5% ointment and timolol maleate 0.5% eye drops in the treatment of proliferating superficial infantile hemangioma.[Pubmed:25633200]
Dermatology. 2015;230(2):150-5.
BACKGROUND: Infantile hemangiomas (IHs) are common childhood tumors. OBJECTIVE: Our study aimed to compare the efficacy and side effects of imiquimod and timolol maleate for the treatment of proliferating superficial IHs. METHODS: A total of 54 patients with superficial IHs were enrolled in this study. Each lesion was evenly divided into two parts. One part was treated with 5% imiquimod cream once every other day, and the other part was smeared with 0.5% timolol maleate eye drops thrice daily. After 16 weeks of treatment, the thickness, color and size of each lesion were measured, and the side effects were recorded. RESULTS: The efficacy rates for imiquimod and timolol maleate were 81.4 and 88.9%, respectively, but the difference between treatments was not significant. However, timolol maleate showed better effects for color involution, onset time and side effects than imiquimod. CONCLUSION: Timolol maleate might be the first choice for the topical treatment of superficial IHs.
Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7agonist.
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