Chamaejasmenin CCAS# 89595-70-0 |
- Ruixianglangdusu B
Catalog No.:BCN6869
CAS No.:447454-49-1
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 89595-70-0 | SDF | Download SDF |
| PubChem ID | 102004812 | Appearance | Powder |
| Formula | C33H28O10 | M.Wt | 584.6 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2R,3S)-5,7-dihydroxy-3-[(2S,3R)-5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-2-(4-methoxyphenyl)-2,3-dihydrochromen-4-one | ||
| SMILES | COC1=CC=C(C=C1)C2C(C(=O)C3=C(C=C(C=C3O2)O)O)C4C(OC5=CC(=CC(=C5C4=O)O)OC)C6=CC=C(C=C6)OC | ||
| Standard InChIKey | RCENZFSDCKZBLJ-PPYDQSFFSA-N | ||
| Standard InChI | InChI=1S/C33H28O10/c1-39-19-8-4-16(5-9-19)32-28(30(37)26-22(35)12-18(34)13-24(26)42-32)29-31(38)27-23(36)14-21(41-3)15-25(27)43-33(29)17-6-10-20(40-2)11-7-17/h4-15,28-29,32-36H,1-3H3/t28-,29+,32+,33-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Chamaejasmenin C Dilution Calculator
Chamaejasmenin C Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.7106 mL | 8.5529 mL | 17.1057 mL | 34.2114 mL | 42.7643 mL |
| 5 mM | 0.3421 mL | 1.7106 mL | 3.4211 mL | 6.8423 mL | 8.5529 mL |
| 10 mM | 0.1711 mL | 0.8553 mL | 1.7106 mL | 3.4211 mL | 4.2764 mL |
| 50 mM | 0.0342 mL | 0.1711 mL | 0.3421 mL | 0.6842 mL | 0.8553 mL |
| 100 mM | 0.0171 mL | 0.0855 mL | 0.1711 mL | 0.3421 mL | 0.4276 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Mogroside VI
Catalog No.:BCN2578
CAS No.:89590-98-7
- Mogroside IV
Catalog No.:BCN2532
CAS No.:89590-95-4
- Flumatinib mesylate
Catalog No.:BCC3970
CAS No.:895519-91-2
- SC 144
Catalog No.:BCC1171
CAS No.:895158-95-9
- Methylneoquassin
Catalog No.:BCN3121
CAS No.:89498-93-1
- Picrasinol B
Catalog No.:BCN4440
CAS No.:89498-91-9
- TCS JNK 6o
Catalog No.:BCC7607
CAS No.:894804-07-0
- ST 2825
Catalog No.:BCC1967
CAS No.:894787-30-5
- BIBF 1202
Catalog No.:BCC5298
CAS No.:894783-71-2
- DMOG
Catalog No.:BCC2433
CAS No.:89464-63-1
- [D-Trp7,9,10]-Substance P
Catalog No.:BCC7202
CAS No.:89430-38-6
- STF-118804
Catalog No.:BCC4850
CAS No.:894187-61-2
- Chamaejasmenin A
Catalog No.:BCN3044
CAS No.:89595-71-1
- 2-Acetamidoethyl phosphate
Catalog No.:BCN1760
CAS No.:89603-45-2
- Imiquimod maleate
Catalog No.:BCC4197
CAS No.:896106-16-4
- trans-3-Oxo-alpha-ionol
Catalog No.:BCN3385
CAS No.:896107-70-3
- AT9283
Catalog No.:BCC2173
CAS No.:896466-04-9
- BMH-21
Catalog No.:BCC5580
CAS No.:896705-16-1
- VX-11e
Catalog No.:BCC2051
CAS No.:896720-20-0
- Androstadienedione
Catalog No.:BCC8824
CAS No.:897-06-3
- KX2-391
Catalog No.:BCC5080
CAS No.:897016-82-9
- 7-O-Acetyl-4-O-demethylpolysyphorin
Catalog No.:BCN3984
CAS No.:89706-39-8
- AST-1306
Catalog No.:BCC3727
CAS No.:897383-62-9
- Toremifene
Catalog No.:BCC2010
CAS No.:89778-26-7
In vitro anti-cancer activity of chamaejasmenin B and neochamaejasmin C isolated from the root of Stellera chamaejasme L.[Pubmed:23222270]
Acta Pharmacol Sin. 2013 Feb;34(2):262-70.
AIM: To examine the anti-cancer effects of chamaejasmenin B and neochamaejasmin C, two biflavonones isolated from the root of Stellera chamaejasme L (known as the traditional Chinese herb Rui Xiang Lang Du) in vitro. METHODS: Human liver carcinoma cell lines (HepG2 and SMMC-7721), a human non-small cell lung cancer cell line (A549), human osteosarcoma cell lines (MG63, U2OS, and KHOS), a human colon cancer cell line (HCT-116) and a human cervical cancer cell line (HeLa) were used. The anti-proliferative effects of the compounds were measured using SRB cytotoxicity assay. DNA damage was detected by immunofluorescence and Western blotting. Apoptosis and cell cycle distribution were assessed using flow cytometry analysis. The expression of the related proteins was examined with Western blotting analysis. RESULTS: Both chamaejasmenin B and neochamaejasmin C exerted potent anti-proliferative effects in the 8 human solid tumor cell lines. Chamaejasmenin B (the IC(50) values ranged from 1.08 to 10.8 mumol/L) was slightly more potent than neochamaejasmin C (the IC(50) values ranged from 3.07 to 15.97 mumol/L). In the most sensitive A549 and KHOS cells, the mechanisms underlying the anti-proliferative effects were characterized. The two compounds induced prominent expression of the DNA damage marker gamma-H2AX as well as apoptosis. Furthermore, treatment of the cells with the two compounds caused prominent G(0)/G(1) phase arrest. CONCLUSION: Chamaejasmenin B and neochamaejasmin C are potential anti-proliferative agents in 8 human solid tumor cell lines in vitro via inducing cell cycle arrest, apoptosis and DNA damage.
