SC 144Gp130 inhibitor CAS# 895158-95-9 |
- Verteporfin
Catalog No.:BCC3690
CAS No.:129497-78-5
- Methylcobalamin
Catalog No.:BCC5188
CAS No.:13422-55-4
- Miglustat hydrochloride
Catalog No.:BCC5186
CAS No.:210110-90-0
- Miglustat
Catalog No.:BCC5187
CAS No.:72599-27-0
- Grape Seed Extract
Catalog No.:BCC5317
CAS No.:84929-27-1
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 895158-95-9 | SDF | Download SDF |
| PubChem ID | 400169 | Appearance | Powder |
| Formula | C16H11FN6O | M.Wt | 322.3 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 16.67 mg/mL (51.72 mM; Need ultrasonic) | ||
| Chemical Name | N'-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide | ||
| SMILES | C1=CN2C3=C(C=C(C=C3)F)N=C(C2=C1)NNC(=O)C4=NC=CN=C4 | ||
| Standard InChIKey | UEADAWQSJOWXBK-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C16H11FN6O/c17-10-3-4-13-11(8-10)20-15(14-2-1-7-23(13)14)21-22-16(24)12-9-18-5-6-19-12/h1-9H,(H,20,21)(H,22,24) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | SC144 is an inhibitor of gp130 with IC50 values of 0.43 μmol/L and 0.88 μmol/L in NCI/ADR-RES and HEY cell lines, respectively | |||||
| Targets | gp130 | |||||
SC 144 Dilution Calculator
SC 144 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.1027 mL | 15.5135 mL | 31.027 mL | 62.054 mL | 77.5675 mL |
| 5 mM | 0.6205 mL | 3.1027 mL | 6.2054 mL | 12.4108 mL | 15.5135 mL |
| 10 mM | 0.3103 mL | 1.5513 mL | 3.1027 mL | 6.2054 mL | 7.7567 mL |
| 50 mM | 0.0621 mL | 0.3103 mL | 0.6205 mL | 1.2411 mL | 1.5513 mL |
| 100 mM | 0.031 mL | 0.1551 mL | 0.3103 mL | 0.6205 mL | 0.7757 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
SC144 is an inhibitor of gp130 with IC50 values of 0.43 μmol/L and 0.88 μmol/L in NCI/ADR-RES and HEY cell lines, respectively [1].
SC144 is a first-in-class small-molecule gp130 inhibitor with oral activity in ovarian cancer. It can substantially increase the phosphorylation of gp130 (S782) in both OVCAR-8 and Caov-3 cells in a time- and dose-dependent manner. The increase phosphorylation then suppresses Stat3 signaling pathway since the constitutive Stat3 activation is maintained by extracellular gp130 ligands, Besides that, SC144 also causes substantial cell apoptosis in these cells. [1].
Apart from the effect on gp130, it has been reported that SC144 can directly bind and stabilize IL-24 in cancer cells. Additionally, SC144 has shown to have effects on cell cycle perturbation and apoptosis induction [2].
SC144 may also have other cellular protein targets, resulting in multiple potential molecular mechanisms. SC144’s anticancer potency may be a sum of these effects [2].
References:
[1] Shili Xu, Fedora Grande, Antonio Garofalo, et al. Discovery of a Novel Orally Active Small-Molecule gp130 Inhibitor for the Treatment of Ovarian Cancer. Molecular Cancer Therapeutics. 2013 (12): 937-949.
[2] Shili Xu, Takashi Oshima, Toshio Imada, Munetaka Masuda, Bikash Debnath, Fedora Grande, Antonio Garofalo, Nouri Neamati. Stabilization of MDA-7/IL-24 for colon cancer therapy. Cancer Letters. 2013 Feb(335):421-430.
- Methylneoquassin
Catalog No.:BCN3121
CAS No.:89498-93-1
- Picrasinol B
Catalog No.:BCN4440
CAS No.:89498-91-9
- TCS JNK 6o
Catalog No.:BCC7607
CAS No.:894804-07-0
- ST 2825
Catalog No.:BCC1967
CAS No.:894787-30-5
- BIBF 1202
Catalog No.:BCC5298
CAS No.:894783-71-2
- DMOG
Catalog No.:BCC2433
CAS No.:89464-63-1
- [D-Trp7,9,10]-Substance P
Catalog No.:BCC7202
CAS No.:89430-38-6
- STF-118804
Catalog No.:BCC4850
CAS No.:894187-61-2
- Raddeanin A
Catalog No.:BCN1084
CAS No.:89412-79-3
- LDN 212320
Catalog No.:BCC6361
CAS No.:894002-50-7
- VU 0240551
Catalog No.:BCC5424
CAS No.:893990-34-6
- Imidapril HCl
Catalog No.:BCC3792
CAS No.:89396-94-1
- Flumatinib mesylate
Catalog No.:BCC3970
CAS No.:895519-91-2
- Mogroside IV
Catalog No.:BCN2532
CAS No.:89590-95-4
- Mogroside VI
Catalog No.:BCN2578
CAS No.:89590-98-7
- Chamaejasmenin C
Catalog No.:BCN3043
CAS No.:89595-70-0
- Chamaejasmenin A
Catalog No.:BCN3044
CAS No.:89595-71-1
- 2-Acetamidoethyl phosphate
Catalog No.:BCN1760
CAS No.:89603-45-2
- Imiquimod maleate
Catalog No.:BCC4197
CAS No.:896106-16-4
- trans-3-Oxo-alpha-ionol
Catalog No.:BCN3385
CAS No.:896107-70-3
- AT9283
Catalog No.:BCC2173
CAS No.:896466-04-9
- BMH-21
Catalog No.:BCC5580
CAS No.:896705-16-1
- VX-11e
Catalog No.:BCC2051
CAS No.:896720-20-0
- Androstadienedione
Catalog No.:BCC8824
CAS No.:897-06-3
Electrospray ionization mass spectrometry of intrinsically cationized nanoparticles, [Au(144/146)(SC(11)H(22)N(CH(2)CH(3))(3)(+))(x)(S(CH(2))(5)CH(3))(y)](x+).[Pubmed:19845358]
J Am Chem Soc. 2009 Nov 11;131(44):16266-71.
Electrospray ionization triple-quadrupole mass spectrometry of ca. 1.6 nm diameter thiolate-protected gold nanoparticles has been achieved at higher resolution than in previous reports. The results reveal the presence of nanoparticles with formulas Au(144)L(60) and Au(146)L(59), present in the sample as a mixture. The improved resolution is based on lowering m/z by exchanging multiple [-SC(11)H(22)N(CH(2)CH(3))(3)(+)] ligands into the original [-S(CH(2))(5)CH(3)] ligand shell. The nanoparticles are thus intrinsically cationized and appear as a series of 10+ to 15+ mass spectral peaks. The assigned state of charge was confirmed by a collision-induced dissociation measurement.
