Sikokianin CCAS# 159813-69-1 |
- Sikokianin A
Catalog No.:BCN3133
CAS No.:106293-99-6
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 159813-69-1 | SDF | Download SDF |
| PubChem ID | 101676234 | Appearance | Powder |
| Formula | C31H24O10 | M.Wt | 556.52 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2R,3S)-3-[(2S,3R)-5,7-dihydroxy-2-(4-methoxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one | ||
| SMILES | COC1=CC=C(C=C1)C2C(C(=O)C3=C(C=C(C=C3O2)O)O)C4C(OC5=CC(=CC(=C5C4=O)O)O)C6=CC=C(C=C6)O | ||
| Standard InChIKey | QOPUSVUZHPIYER-VGGPVXIDSA-N | ||
| Standard InChI | InChI=1S/C31H24O10/c1-39-19-8-4-15(5-9-19)31-27(29(38)25-21(36)11-18(34)13-23(25)41-31)26-28(37)24-20(35)10-17(33)12-22(24)40-30(26)14-2-6-16(32)7-3-14/h2-13,26-27,30-36H,1H3/t26-,27+,30+,31-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Sikokianin C shows antimalarial activity against the chloroquine-resistant strain of Plasmodium falciparum, with the IC (50) value of 0.56 microg/mL. |
| Targets | NO | NOS | IFN-γ | Antifection |
Sikokianin C Dilution Calculator
Sikokianin C Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.7969 mL | 8.9844 mL | 17.9688 mL | 35.9376 mL | 44.922 mL |
| 5 mM | 0.3594 mL | 1.7969 mL | 3.5938 mL | 7.1875 mL | 8.9844 mL |
| 10 mM | 0.1797 mL | 0.8984 mL | 1.7969 mL | 3.5938 mL | 4.4922 mL |
| 50 mM | 0.0359 mL | 0.1797 mL | 0.3594 mL | 0.7188 mL | 0.8984 mL |
| 100 mM | 0.018 mL | 0.0898 mL | 0.1797 mL | 0.3594 mL | 0.4492 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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In vitro antimalarial activity of biflavonoids from Wikstroemia indica.[Pubmed:14765300]
Planta Med. 2004 Jan;70(1):76-8.
In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect. Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B ( 1) and Sikokianin C ( 2) with IC (50) values 0.54 microg/mL and 0.56 microg/mL, respectively, against the chloroquine-resistant strain of Plasmodium falciparum. This is the first report of the biological activity of 1 and 2. As the structure of l has remained unsettled, we confirmed the conformation by (1)H- and (13)C-NMR.
Anti-inflammatory activity of new guaiane type sesquiterpene from Wikstroemia indica.[Pubmed:15635251]
Chem Pharm Bull (Tokyo). 2005 Jan;53(1):137-9.
In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage-like cell line, RAW 264.7. Fractionation of the active extract led to the isolation of one new guaiane type sesquiterpene, indicanone (1), and two known biflavonoids, sikokianin B (2) and Sikokianin C (3). 1 inhibited NO production with IC50 values at 9.3 microM and also inhibit the inducible nitric oxide synhase (iNOS) gene expression. This is the first report of NO production inhibitory activity of Wikstroemia indica and supports the pharmacological use of it, which has been employed as an herbal medicine for the treatment of inflammation.
