Mc-Val-Cit-PABC-PNPCAS# 159857-81-5 |
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Quality Control & MSDS
3D structure
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| Cas No. | 159857-81-5 | SDF | Download SDF |
| PubChem ID | 57587849 | Appearance | Powder |
| Formula | C35H43N7O11 | M.Wt | 737.76 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate | ||
| Solubility | DMSO : ≥ 37 mg/mL (50.15 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate | ||
| SMILES | CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)CCCCCN3C(=O)C=CC3=O | ||
| Standard InChIKey | HYSPJPGXSALJRR-DHIFEGFHSA-N | ||
| Standard InChI | InChI=1S/C35H43N7O11/c1-22(2)31(40-28(43)8-4-3-5-20-41-29(44)17-18-30(41)45)33(47)39-27(7-6-19-37-34(36)48)32(46)38-24-11-9-23(10-12-24)21-52-35(49)53-26-15-13-25(14-16-26)42(50)51/h9-18,22,27,31H,3-8,19-21H2,1-2H3,(H,38,46)(H,39,47)(H,40,43)(H3,36,37,48)/t27-,31-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC peptide linker. FDA approved drug, brentuximab vedotin, adopts this linker. References: | |||||
Mc-Val-Cit-PABC-PNP Dilution Calculator
Mc-Val-Cit-PABC-PNP Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.3555 mL | 6.7773 mL | 13.5545 mL | 27.1091 mL | 33.8864 mL |
| 5 mM | 0.2711 mL | 1.3555 mL | 2.7109 mL | 5.4218 mL | 6.7773 mL |
| 10 mM | 0.1355 mL | 0.6777 mL | 1.3555 mL | 2.7109 mL | 3.3886 mL |
| 50 mM | 0.0271 mL | 0.1355 mL | 0.2711 mL | 0.5422 mL | 0.6777 mL |
| 100 mM | 0.0136 mL | 0.0678 mL | 0.1355 mL | 0.2711 mL | 0.3389 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker.
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Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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