Wikstrol A

CAS# 159736-35-3

Wikstrol A

Catalog No. BCN7938----Order now to get a substantial discount!

Product Name & Size Price Stock
Wikstrol A: 5mg $978 In Stock
Wikstrol A: 10mg Please Inquire In Stock
Wikstrol A: 20mg Please Inquire Please Inquire
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Quality Control of Wikstrol A

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Chemical structure

Wikstrol A

3D structure

Chemical Properties of Wikstrol A

Cas No. 159736-35-3 SDF Download SDF
PubChem ID 5494382 Appearance Powder
Formula C30H22O10 M.Wt 542.49
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[3,5,7-trihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-8-yl]chromen-4-one
SMILES C1C(C(OC2=C(C(=CC(=C21)O)O)C3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC=C(C=C5)O)C6=CC=C(C=C6)O)O
Standard InChIKey SRCSHETVEHQXLC-UHFFFAOYSA-N
Standard InChI InChI=1S/C30H22O10/c31-15-5-1-13(2-6-15)28-22(37)11-18-19(34)12-21(36)25(30(18)40-28)26-27(38)24-20(35)9-17(33)10-23(24)39-29(26)14-3-7-16(32)8-4-14/h1-10,12,22,28,31-37H,11H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Wikstrol A

The roots of Daphne genkwa

Biological Activity of Wikstrol A

DescriptionWikstrol A is a natural product from Daphne genkwa.
In vitro

Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica.[Pubmed: 10985087]

Planta Med. 2000 Aug;66(6):564-7.


METHODS AND RESULTS:
With guidance of Pyricularia oryzae bioassay, daphnoretin (1), (+)-nortrachelogenin (2), genkwanol A (3), Wikstrol A (4), wikstrol B (5) and daphnodorin B (6) were isolated from the roots of Wikstroemia indica. Compounds 1-6 induced morphological deformation of P. oryzae mycelia with MMDC values of 68.4 +/- 1.3, 31.3 +/- 1.8, 45.8 +/- 0.5, 70.1 +/- 2.4, 52.3 +/- 0.9 and 73.7 +/- 1.6 microM, respectively. Compounds 3-6 showed moderate activity against microtubule polymerization with IC50 values of 112 +/- 4, 131 +/- 3, 184 +/- 6 and 142 +/- 2 microM in vitro, respectively. Compounds 2, 3, 5 and 6 were moderately active against HIV-1 in vitro.
CONCLUSIONS:
The findings of bioactivity of 1-6 support the antifungus, antimitosis and anti-HIV-1 uses for W. indica roots.

Aldose Reductase Inhibitors from Stellera chamaejasme.[Reference: WebLink]

Pharmaceutical Biology, 2005, 43(1):12-14.


METHODS AND RESULTS:
Six biflavonoids (chamaejasmin, 7-methoxyneochamaejasmin, 7-methoxychamaejasmin, chamaejasmenin B, chamaechromone, Wikstrol A) from Stellera chamaejasme. L. have been assayed to show good aldose reductase inhibiting activity.
CONCLUSIONS:
These compounds may be useful to improve diabetic complications such as neuropathy, cataract formation, neophropathy, and retinopathy.

Wikstrol A Dilution Calculator

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Wikstrol A Molarity Calculator

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Preparing Stock Solutions of Wikstrol A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8434 mL 9.2168 mL 18.4335 mL 36.867 mL 46.0838 mL
5 mM 0.3687 mL 1.8434 mL 3.6867 mL 7.3734 mL 9.2168 mL
10 mM 0.1843 mL 0.9217 mL 1.8434 mL 3.6867 mL 4.6084 mL
50 mM 0.0369 mL 0.1843 mL 0.3687 mL 0.7373 mL 0.9217 mL
100 mM 0.0184 mL 0.0922 mL 0.1843 mL 0.3687 mL 0.4608 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Wikstrol A

Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica.[Pubmed:10985087]

Planta Med. 2000 Aug;66(6):564-7.

With guidance of Pyricularia oryzae bioassay, daphnoretin (1), (+)-nortrachelogenin (2), genkwanol A (3), Wikstrol A (4), wikstrol B (5) and daphnodorin B (6) were isolated from the roots of Wikstroemia indica. Compounds 1-6 induced morphological deformation of P. oryzae mycelia with MMDC values of 68.4 +/- 1.3, 31.3 +/- 1.8, 45.8 +/- 0.5, 70.1 +/- 2.4, 52.3 +/- 0.9 and 73.7 +/- 1.6 microM, respectively. Compounds 3-6 showed moderate activity against microtubule polymerization with IC50 values of 112 +/- 4, 131 +/- 3, 184 +/- 6 and 142 +/- 2 microM in vitro, respectively. Compounds 2, 3, 5 and 6 were moderately active against HIV-1 in vitro. The findings of bioactivity of 1-6 support the antifungus, antimitosis and anti-HIV-1 uses for W. indica roots.

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