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2,3,24-Trihydroxy-12-ursen-28-oic acid

CAS# 89786-83-4

2,3,24-Trihydroxy-12-ursen-28-oic acid

Catalog No. BCN1314----Order now to get a substantial discount!

Product Name & Size Price Stock
2,3,24-Trihydroxy-12-ursen-28-oic acid: 5mg $828 In Stock
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Quality Control of 2,3,24-Trihydroxy-12-ursen-28-oic acid

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Chemical structure

2,3,24-Trihydroxy-12-ursen-28-oic acid

3D structure

Chemical Properties of 2,3,24-Trihydroxy-12-ursen-28-oic acid

Cas No. 89786-83-4 SDF Download SDF
PubChem ID 12308659 Appearance Powder
Formula C30H48O5 M.Wt 488.7
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1S,2R,4aS,6aR,6aS,6bR,8aR,9S,10S,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
SMILES CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)CO)O)O)C)C)C2C1C)C)C(=O)O
Standard InChIKey JXSVIVRDWWRQRT-UMCOSQRYSA-N
Standard InChI InChI=1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24-,26+,27-,28-,29-,30+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 2,3,24-Trihydroxy-12-ursen-28-oic acid

The herbs of Callicarpa bodinieri Levl.

Biological Activity of 2,3,24-Trihydroxy-12-ursen-28-oic acid

Description2α,3α,24-Trihydroxyurs-12-en-28-oic acid, a triterpenoid phytoalexin, shows antifungal activity against the fungus mentioned. It also shows in vitro cytotoxic activity against tumor cell lines including PLC,Hep3B,HepG2,HeLa,SW480,MCF-7 and Bel7402.
TargetsAntifection
In vitro

Four Triterpenoids with Cytotoxic Activity from the Leaves of Actinidia valvata[Reference: WebLink]

Chinese Journal of Natural Medicines, 2010, 8(4):260-3.

To study the chemical constituents of the leaves of Actinidia valvata Dunn.
METHODS AND RESULTS:
Several chromatographic methods were applied to isolate and purify compounds and their structures were elucidated by spectroscopic methods. Four triterpenoids including corosolic acid(1),2α,3β,24-trihydroxyurs-12-en-28-oic acid(2,3,24-Trihydroxy-12-ursen-28-oic acid ,2),2α,3α,24-trihydroxyurs-12-en-28-oic acid(3) and 2α,3α,19α,24-tetrahydroxyurs-12-en-28-oic acid(4) were isolated from Actinidia valvata Dunn.They all showed in vitro cytotoxic activity against tumor cell lines including PLC,Hep3B,HepG2,HeLa,SW480,MCF-7 and Bel7402.
CONCLUSIONS:
These 4 compounds were all obtained from the plant for the first time.

Protocol of 2,3,24-Trihydroxy-12-ursen-28-oic acid

Structure Identification
Phytochemistry, 1999, 52(4):623-9.

Triterpene phytoalexins from nectarine fruits[Reference: WebLink]


METHODS AND RESULTS:
Seven triterpenoid phytoalexins were isolated from peel of unripe fruits of nectarine (Prunus persica cv Fantasia) wounded and inoculated with Colletotrichum musae. Two were new triterpenoids, identified as 1β,2α,3α,24-tetrahydroxyurs-12-en-28-oic acid and 1β,2α,3α,24-tetrahydroxyolean-12-en-28-oic acid. 2α,3α,24-Trihydroxyolean-12-en-28-oic acid, 2α,3α,24-trihydroxyurs-12-en-28-oic acid(2,3,24-Trihydroxy-12-ursen-28-oic acid), 2α,3β,24-trihydroxyolean-12-en-28-oic acid, 2α,3α-dihydroxyolean-12-en-28-oic acid, and 2α,3α-dihydroxyurs-12-en-28-oic acid were previously reported as constitutive natural products from other plants, but were never described as phytoalexins.
CONCLUSIONS:
All showed antifungal activity against the fungus mentioned.

2,3,24-Trihydroxy-12-ursen-28-oic acid Dilution Calculator

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2,3,24-Trihydroxy-12-ursen-28-oic acid Molarity Calculator

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Preparing Stock Solutions of 2,3,24-Trihydroxy-12-ursen-28-oic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0462 mL 10.2312 mL 20.4625 mL 40.9249 mL 51.1561 mL
5 mM 0.4092 mL 2.0462 mL 4.0925 mL 8.185 mL 10.2312 mL
10 mM 0.2046 mL 1.0231 mL 2.0462 mL 4.0925 mL 5.1156 mL
50 mM 0.0409 mL 0.2046 mL 0.4092 mL 0.8185 mL 1.0231 mL
100 mM 0.0205 mL 0.1023 mL 0.2046 mL 0.4092 mL 0.5116 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2,3,24-Trihydroxy-12-ursen-28-oic acid

Triterpene phytoalexins from nectarine fruits

Phytochemistry, 1999, 52(4):623-9.

Seven triterpenoid phytoalexins were isolated from peel of unripe fruits of nectarine (Prunus persica cv Fantasia) wounded and inoculated with Colletotrichum musae. Two were new triterpenoids, identified as 1β,2α,3α,24-tetrahydroxyurs-12-en-28-oic acid and 1β,2α,3α,24-tetrahydroxyolean-12-en-28-oic acid. 2α,3α,24-Trihydroxyolean-12-en-28-oic acid, 2α,3α,24-trihydroxyurs-12-en-28-oic acid, 2α,3β,24-trihydroxyolean-12-en-28-oic acid, 2α,3α-dihydroxyolean-12-en-28-oic acid, and 2α,3α-dihydroxyurs-12-en-28-oic acid were previously reported as constitutive natural products from other plants, but were never described as phytoalexins. All showed antifungal activity against the fungus mentioned.

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