Effect of the Phytochemical Agents against the SARS-CoV and Some of them Selected for Application to COVID-19. Many plants including Hopea, Vitis, Shorea and Anisoptera, are sources of these Phytochemical compounds. The epidemic of Covid-19 disease caused by SARS-CoV-19, as well as the lack of targeted drugs and vaccines, has forced the scientific community to search for new antiviral formulations. In this review, we describe the current knowledge of plant extracts containing polyphenols that inhibit Covid-19. Many natural plant-derived compounds (polyphenols) could provide a starting point for research on the use of plant extracts in the treatment and prevention of coronavirus. Antiviral polyphenolic drugs can inhibit coronavirus enzymes, which are essential for virus replication and infection. This group of natural substances (betulinic acid, indigo, aloeemodin, luteolin and quinomethyl triterpenoids, quercitin or gallates) is a potential key to designing antiviral therapies to inhibit viral proteases. The known pharmacophore structures of the bioactive substances may be useful in the development of new anti-Covid-19 formulations. The advantage of using preparations containing phytochemicals is their high safety for patients and the absence of side effects.