AloeemodinCAS# 481-72-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 481-72-1 | SDF | Download SDF |
PubChem ID | 10207 | Appearance | Orange powder |
Formula | C15H10O5 | M.Wt | 270.2 |
Type of Compound | Anthraquinones | Storage | Desiccate at -20°C |
Synonyms | Rhabarberone; 3-Hydroxymethylchrysazine | ||
Solubility | DMSO : 41.67 mg/mL (154.20 mM; Need ultrasonic) Ethanol : 1 mg/mL (3.70 mM; Need ultrasonic and warming) H2O : < 0.1 mg/mL (insoluble) | ||
Chemical Name | 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione | ||
SMILES | C1=CC2=C(C(=C1)O)C(=O)C3=C(C=C(C=C3C2=O)CO)O | ||
Standard InChIKey | YDQWDHRMZQUTBA-UHFFFAOYSA-N | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Aloeemodin is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71. Aloeemodin has antitumor, neuroprotective, and anti-fibrosis effects, it inhibited β-amyloid aggregation, downregulated the expression of Smad2 mRNA and TGF-β1,TIMP1,and type Ⅰ and Ⅲ collagen proteins,and upregulated the expression of Smad7 mRNA. |
Targets | Calcium Channel | ROS | Beta Amyloid | TGF-β/Smad | MMP(e.g.TIMP) | FAK | VEGFR |
In vitro | Genotoxicity of aloeemodin in vitro and in vivo.[Pubmed: 8600368]Mutat Res. 1996 Mar 1;367(3):123-33.The present in vitro and in vivo experiments were undertaken to clarify the genotoxic potential of the hydroxyanthrachinone Aloeemodin which can be found in different plant derived products for therapy of constipation.
Inhibition of β-Amyloid Aggregation by Albiflorin, Aloeemodin and Neohesperidin and their Neuroprotective Effect on Primary Hippocampal Cells Against β-Amyloid Induced Toxicity.[Pubmed: 25938872]Curr Alzheimer Res. 2015;12(5):424-33.Being one of the hallmarks of Alzheimer's disease, β-amyloid (Aβ) aggregates induce complicated neurotoxicity. Evidences show that the underlying mechanism of neurotoxicity involves a glutamate receptor subtype, N-methyl-D-aspartate (NMDA) receptor, an increase in intracellular calcium(II) ion loading as well as an elevation in oxidation stress.
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In vivo | Effects of combined use of aloeemodin and praziquantel on the transforming growth factor-β/Smad pathway in mice with schistosomiasis-induced liver fibrosis.[Reference: WebLink]World Chinese Journal of Digestology, 2009, 17(27):2778-83.To investigate the effects of combined use of Aloeemodin and praziquantel on the transforming growth factor-β (TGF-β)/Smad pathway in mice with schistosomiasis-induced liver fibrosis. |
Cell Research | Effects of aloeemodin on proliferation cycle and apoptotic of human stomach cancer cell line HGC-27.[Reference: WebLink]J. Modern Oncol., 2008, 16(06):919-21.To study the suppressive role of Aloeemodin on the growth and its effect on the proliferation cycle and apoptosis of human stomach cancer cell line HGC-27.
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Animal Research | Effect of aloeemodin on liver fibrosis induced by Schistosoma Japonicum infections in mice.[Reference: WebLink]Chinese Journal of Integrated Traditional & Western Medicine on Liver Diseases, 2012, 22(02):107-9.To observe the effect of Aloeemodin on liver fibrosis mice in duced by Schistosoma Japonicum. |
Aloeemodin Dilution Calculator
Aloeemodin Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 3.701 mL | 18.5048 mL | 37.0096 mL | 74.0192 mL | 92.5241 mL |
5 mM | 0.7402 mL | 3.701 mL | 7.4019 mL | 14.8038 mL | 18.5048 mL |
10 mM | 0.3701 mL | 1.8505 mL | 3.701 mL | 7.4019 mL | 9.2524 mL |
50 mM | 0.074 mL | 0.3701 mL | 0.7402 mL | 1.4804 mL | 1.8505 mL |
100 mM | 0.037 mL | 0.185 mL | 0.3701 mL | 0.7402 mL | 0.9252 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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Aloe emodin is a hydroxyanthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antitumor activity. IC50 value: Target: in vitro: aloe-emodin treatment led to the dissociation of heat shock protein 90 (HSP90) and ER α and increased ER α ubiquitination. Protein fractionation results suggest that aloe-emodin tended to induce cytosolic ER α degradation [1]. Aloe-emodin, a natural compound found in aloe, inhibited both proliferation and anchorage-independent growth of PC3 cells. Protein content analysis suggested that activation of the downstream substrates of mTORC2, Akt and PKCα, was inhibited by aloe-emodin treatment. Pull-down assay and in vitro kinase assay results indicated that aloe-emodin could bind with mTORC2 in cells and inhibit its kinase activity [2]. Of three anthraquinone derivatives, aloe-emodin, with a lower cytotoxicity showed concentration-dependently reducing virus-induced cytopathic effect and inhibiting replication of influenza A in MDCK cells. Galectin-3 also inhibited influenza A virus replication. Proteomic analysis of treated cells indicated galectin-3 up-regulation as one anti-influenza A virus action by aloe-emodin. Since galectin-3 exhibited cytokine-like regulatory actions via JAK/STAT pathways, aloe-emodin also restored NS1-inhibited STAT1-mediated antiviral responses in transfected cells: e.g., STAT1 phosphorylation of interferon (IFN) stimulation response element (ISRE)-driven promoter, RNA-dependent protein kinase (PKR) and 2'5',-oligoadenylate synthetase (2'5',-OAS) expression [3]. AE downregulated mRNA expression and promoter/gelatinolytic activity of Matrix Metalloproteinase (MMP)-2/9, as well as the RhoB expression at gene and protein level. AE suppressed the nuclear translocation and DNA binding of NF-κB [4]. in vivo: Aloe-emodin also exhibited tumor suppression effects in vivo in an athymic nude mouse model [2].
References:
[1]. Huang PH, et al. Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition. Evid Based Complement Alternat Med. 2013;2013:376123.
[2]. Liu K, et al. Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2. Carcinogenesis. 2012 Jul;33(7):1406-11.
[3]. Li SW, et al. Antiviral activity of aloe-emodin against influenza A virus via galectin-3 up-regulation. Eur J Pharmacol. 2014 Sep 5;738:125-32.
[4]. Suboj P, et al. Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB. Eur J Pharm Sci. 2012 Apr 11;45(5):581-91.
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Inhibition of beta-amyloid Aggregation By Albiflorin, Aloeemodin And Neohesperidin And Their Neuroprotective Effect On Primary Hippocampal Cells Against beta-amyloid Induced Toxicity.[Pubmed:25938872]
Curr Alzheimer Res. 2015;12(5):424-33.
Being one of the hallmarks of Alzheimer's disease, beta-amyloid (Abeta) aggregates induce complicated neurotoxicity. Evidences show that the underlying mechanism of neurotoxicity involves a glutamate receptor subtype, N-methyl-D-aspartate (NMDA) receptor, an increase in intracellular calcium(II) ion loading as well as an elevation in oxidation stress. In this work, among the 35 chemical components of Chinese herbal medicines (CHMs) being screened for inhibitors of Abeta aggregation, four of them, namely albiflorin, Aloeemodin, neohesperidin and physcion, were found for the first time to exhibit a potent inhibitory effect on Abeta(1-40) and Abeta(1-42) aggregation. Their neuroprotective capability on primary hippocampal neuronal cells was also investigated by MTT assay, ROS assay and intracellular calcium(II) ion concentration measurement. It was interesting to find that physcion was rather toxic to neuronal cells while albiflorin, Aloeemodin and neohesperidin reduced the toxicity and ROS induced by both monomeric and oligomeric Abeta species. In addition, albiflorin was particularly powerful in maintaining the intracellular Ca(2+) concentration.
Genotoxicity of aloeemodin in vitro and in vivo.[Pubmed:8600368]
Mutat Res. 1996 Mar 1;367(3):123-33.
The present in vitro and in vivo experiments were undertaken to clarify the genotoxic potential of the hydroxyanthrachinone Aloeemodin which can be found in different plant derived products for therapy of constipation. The results demonstrate that Aloeemodin is able to induce mutagenic effects in vitro. Positive results were obtained in the chromosomal aberration assay with CHO cells, as well as in the Salmonella reverse mutation assay (frameshift mutations in strains TA 1537, TA 1538 and TA 98). No mutagenic potential of Aloeemodin, however, was observed in the gene mutation assay with mammalian cells in vitro (HPRT assay in V79 cells). Each assay was performed in the presence and absence of an extrinsic metabolic activation system (S9-mix). In in vivo studies (micronucleus assay in bone marrow cells of NMRI mice; chromosome aberration assay in bone marrow cells of Wistar rats; mouse spot text [DBA/2JxNMRI]) no indication of a mutagenic activity of Aloeemodin was found. Information about a possible reaction of Aloeemodin with DNA was derived from an in vivo UDS assay. Hepatocytes of Aloeemodin-treated male Wistar rats did not show DNA damage via repair synthesis. All these data suggest that Aloeemodin is able to interact with DNA under certain in vitro conditions. However, in vivo the results that were negative did not indicate a genotoxic potential. Therefore, it may be assumed that a genotoxic risk for man might be unlikely.