Ecgonine

CAS# 481-37-8

Ecgonine

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Quality Control of Ecgonine

Number of papers citing our products

Chemical structure

Ecgonine

3D structure

Chemical Properties of Ecgonine

Cas No. 481-37-8 SDF Download SDF
PubChem ID 443003 Appearance Oil
Formula C9H15NO3 M.Wt 185.22
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3S,4R)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylic acid
SMILES CN1C2CCC1C(C(C2)O)C(=O)O
Standard InChIKey PHMBVCPLDPDESM-RLXKETGRSA-N
Standard InChI InChI=1S/C9H15NO3/c1-10-5-2-3-6(10)8(9(12)13)7(11)4-5/h5-8,11H,2-4H2,1H3,(H,12,13)/t5?,6?,7-,8+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Ecgonine

Description1. Ecgonine is a promising marker of cocaine ingestion.

Ecgonine Dilution Calculator

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Ecgonine Molarity Calculator

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Preparing Stock Solutions of Ecgonine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.399 mL 26.9949 mL 53.9898 mL 107.9797 mL 134.9746 mL
5 mM 1.0798 mL 5.399 mL 10.798 mL 21.5959 mL 26.9949 mL
10 mM 0.5399 mL 2.6995 mL 5.399 mL 10.798 mL 13.4975 mL
50 mM 0.108 mL 0.5399 mL 1.0798 mL 2.1596 mL 2.6995 mL
100 mM 0.054 mL 0.2699 mL 0.5399 mL 1.0798 mL 1.3497 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Ecgonine

Determination of ecgonine and seven other cocaine metabolites in human urine and whole blood by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry.[Pubmed:24202193]

Anal Bioanal Chem. 2013 Dec;405(30):9805-16.

Ecgonine is suggested to be a promising marker of cocaine (COC) ingestion. A combined mass spectrometry (MS) and tandem MS (MS/MS) method was developed to simultaneously determine Ecgonine and seven other metabolites of cocaine in human urine and whole blood with ultra-high-pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. The compounds were extracted from as little as 100 muL of sample by solid-phase extraction with a 96-well muElution solid-phase extraction plate. The protonated molecules or fragment ions at accurate mass acquired in MS mode were used to quantify specific analytes, following by dedicated MS/MS identification. The assay was linear in the range from 5 to 50-100 ng/mL for urine samples, except for Ecgonine methyl ester (10-200 ng/mL) and Ecgonine (40-400 ng/mL), and was linear from 1-2 to 50 ng/mL for whole blood samples, except for Ecgonine methyl ester (20-1,000 ng/mL) and Ecgonine (40-2,000 ng/mL). The correlation coefficients were all greater than 0.99. The limits of detection ranged from 0.2 to 16 ng/mL, and the lower limits of quantification ranged from 1 to 40 ng/mL. The repeatability and intermediate precision were 18.1% or less. The accuracy was in the range from 80.0 to 122.9%, process efficiencies were in the range from 8.6 to 177.4%, matrix effects were in the range from 28.7 to 171.0%, and extraction recoveries were in the range from 41.0 to 114.3%, except for Ecgonine (12.8% and 9.3% at low and high concentrations, respectively). This method was highly sensitive in comparison with previously published methods. The validated method was successfully applied to the analysis of real samples derived from forensic cases, and the results verified that, on the basis of data from four positive samples, Ecgonine is a promising marker of cocaine ingestion.

Urinary excretion of ecgonine and five other cocaine metabolites following controlled oral, intravenous, intranasal, and smoked administration of cocaine.[Pubmed:20223096]

J Anal Toxicol. 2010 Mar;34(2):57-63.

Urinary excretion of Ecgonine (EC) was compared to that of cocaine, benzoylEcgonine, Ecgonine methyl ester and minor metabolites, meta-hydroxybenzoylEcgonine, para-hydroxybenzoylEcgonine, and norbenzoylEcgonine, following controlled administration of oral, intravenous, intranasal, and smoked cocaine. Urine EC concentrations peaked later than all other analytes and had longer detection times than the other minor metabolites. With a 50 ng/mL cutoff concentration and following low doses of 10 to 45 mg cocaine by multiple routes, detection times extended up to 98 h. Maximum concentrations (Cmax) were 6-14 mole % of those for benzoylEcgonine, Cmax increased with dose, time to maximum concentration (Tmax) was independent of dose, and route of administration did not have a significant impact on Cmax or Tmax for metabolites. EC is an analyte to consider for identifying cocaine use due to its stability in urine and long detection times.

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