EcgonineCAS# 481-37-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 481-37-8 | SDF | Download SDF |
PubChem ID | 443003 | Appearance | Oil |
Formula | C9H15NO3 | M.Wt | 185.22 |
Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | (3S,4R)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylic acid | ||
SMILES | CN1C2CCC1C(C(C2)O)C(=O)O | ||
Standard InChIKey | PHMBVCPLDPDESM-RLXKETGRSA-N | ||
Standard InChI | InChI=1S/C9H15NO3/c1-10-5-2-3-6(10)8(9(12)13)7(11)4-5/h5-8,11H,2-4H2,1H3,(H,12,13)/t5?,6?,7-,8+/m0/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 1. Ecgonine is a promising marker of cocaine ingestion. |
Ecgonine Dilution Calculator
Ecgonine Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 5.399 mL | 26.9949 mL | 53.9898 mL | 107.9797 mL | 134.9746 mL |
5 mM | 1.0798 mL | 5.399 mL | 10.798 mL | 21.5959 mL | 26.9949 mL |
10 mM | 0.5399 mL | 2.6995 mL | 5.399 mL | 10.798 mL | 13.4975 mL |
50 mM | 0.108 mL | 0.5399 mL | 1.0798 mL | 2.1596 mL | 2.6995 mL |
100 mM | 0.054 mL | 0.2699 mL | 0.5399 mL | 1.0798 mL | 1.3497 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Epiandrosterone
Catalog No.:BCC4481
CAS No.:481-29-8
- alpha-Spinasterol
Catalog No.:BCN5564
CAS No.:481-18-5
- Alpha-Santonin
Catalog No.:BCN7828
CAS No.:481-06-1
- Edoxaban tosylate
Catalog No.:BCC1544
CAS No.:480449-71-6
- Edoxaban
Catalog No.:BCC1543
CAS No.:480449-70-5
- Lucialdehyde B
Catalog No.:BCN2450
CAS No.:480439-84-7
- TFB-TBOA
Catalog No.:BCC5919
CAS No.:480439-73-4
- Carbenicillin, Disodium Salt
Catalog No.:BCC1200
CAS No.:4800-94-6
- Benzofuroxan
Catalog No.:BCC8852
CAS No.:480-96-6
- Dicrotaline
Catalog No.:BCN2079
CAS No.:480-87-5
- Retusine
Catalog No.:BCN2123
CAS No.:480-86-4
- Retronecine
Catalog No.:BCN2034
CAS No.:480-85-3
- Juglone
Catalog No.:BCN2639
CAS No.:481-39-0
- Plumbagin
Catalog No.:BCN2586
CAS No.:481-42-5
- Ginkgetin
Catalog No.:BCN2319
CAS No.:481-46-9
- Cepharanthine
Catalog No.:BCN5393
CAS No.:481-49-2
- Tangeretin
Catalog No.:BCN2386
CAS No.:481-53-8
- Aloeemodin
Catalog No.:BCN5565
CAS No.:481-72-1
- Citreorosein
Catalog No.:BCN5566
CAS No.:481-73-2
- Chrysophanol
Catalog No.:BCN5567
CAS No.:481-74-3
- Estriol 3-sulfate
Catalog No.:BCN2236
CAS No.:481-95-8
- Homoferreirin
Catalog No.:BCN4765
CAS No.:482-01-9
- Byakangelicin 2'-O-Isovalerate
Catalog No.:BCC8899
CAS No.:108006-56-0
- Isopimpinellin
Catalog No.:BCN5568
CAS No.:482-27-9
Determination of ecgonine and seven other cocaine metabolites in human urine and whole blood by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry.[Pubmed:24202193]
Anal Bioanal Chem. 2013 Dec;405(30):9805-16.
Ecgonine is suggested to be a promising marker of cocaine (COC) ingestion. A combined mass spectrometry (MS) and tandem MS (MS/MS) method was developed to simultaneously determine Ecgonine and seven other metabolites of cocaine in human urine and whole blood with ultra-high-pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. The compounds were extracted from as little as 100 muL of sample by solid-phase extraction with a 96-well muElution solid-phase extraction plate. The protonated molecules or fragment ions at accurate mass acquired in MS mode were used to quantify specific analytes, following by dedicated MS/MS identification. The assay was linear in the range from 5 to 50-100 ng/mL for urine samples, except for Ecgonine methyl ester (10-200 ng/mL) and Ecgonine (40-400 ng/mL), and was linear from 1-2 to 50 ng/mL for whole blood samples, except for Ecgonine methyl ester (20-1,000 ng/mL) and Ecgonine (40-2,000 ng/mL). The correlation coefficients were all greater than 0.99. The limits of detection ranged from 0.2 to 16 ng/mL, and the lower limits of quantification ranged from 1 to 40 ng/mL. The repeatability and intermediate precision were 18.1% or less. The accuracy was in the range from 80.0 to 122.9%, process efficiencies were in the range from 8.6 to 177.4%, matrix effects were in the range from 28.7 to 171.0%, and extraction recoveries were in the range from 41.0 to 114.3%, except for Ecgonine (12.8% and 9.3% at low and high concentrations, respectively). This method was highly sensitive in comparison with previously published methods. The validated method was successfully applied to the analysis of real samples derived from forensic cases, and the results verified that, on the basis of data from four positive samples, Ecgonine is a promising marker of cocaine ingestion.
Urinary excretion of ecgonine and five other cocaine metabolites following controlled oral, intravenous, intranasal, and smoked administration of cocaine.[Pubmed:20223096]
J Anal Toxicol. 2010 Mar;34(2):57-63.
Urinary excretion of Ecgonine (EC) was compared to that of cocaine, benzoylEcgonine, Ecgonine methyl ester and minor metabolites, meta-hydroxybenzoylEcgonine, para-hydroxybenzoylEcgonine, and norbenzoylEcgonine, following controlled administration of oral, intravenous, intranasal, and smoked cocaine. Urine EC concentrations peaked later than all other analytes and had longer detection times than the other minor metabolites. With a 50 ng/mL cutoff concentration and following low doses of 10 to 45 mg cocaine by multiple routes, detection times extended up to 98 h. Maximum concentrations (Cmax) were 6-14 mole % of those for benzoylEcgonine, Cmax increased with dose, time to maximum concentration (Tmax) was independent of dose, and route of administration did not have a significant impact on Cmax or Tmax for metabolites. EC is an analyte to consider for identifying cocaine use due to its stability in urine and long detection times.