Home >> Research Area >>Endocrinology and Hormones>>Opioid Receptor>> ICI 199,441 hydrochloride

ICI 199,441 hydrochloride

CAS# 115199-84-3

ICI 199,441 hydrochloride

Catalog No. BCC6792----Order now to get a substantial discount!

Product Name & Size Price Stock
ICI 199,441 hydrochloride: 5mg $92 In Stock
ICI 199,441 hydrochloride: 10mg Please Inquire In Stock
ICI 199,441 hydrochloride: 20mg Please Inquire Please Inquire
ICI 199,441 hydrochloride: 50mg Please Inquire Please Inquire
ICI 199,441 hydrochloride: 100mg Please Inquire Please Inquire
ICI 199,441 hydrochloride: 200mg Please Inquire Please Inquire
ICI 199,441 hydrochloride: 500mg Please Inquire Please Inquire
ICI 199,441 hydrochloride: 1000mg Please Inquire Please Inquire
Related Products
  • KY 02111

    Catalog No.:BCC3628
    CAS No.:1118807-13-8
  • IWR-1-endo

    Catalog No.:BCC5102
    CAS No.:1127442-82-3
  • CCT 031374 hydrobromide

    Catalog No.:BCC6258
    CAS No.:1219184-91-4
  • XAV-939

    Catalog No.:BCC1120
    CAS No.:284028-89-3
  • iCRT 14

    Catalog No.:BCC5401
    CAS No.:677331-12-3
  • IWP-2

    Catalog No.:BCC1665
    CAS No.:686770-61-6

Quality Control of ICI 199,441 hydrochloride

Number of papers citing our products

Chemical structure

ICI 199,441 hydrochloride

3D structure

Chemical Properties of ICI 199,441 hydrochloride

Cas No. 115199-84-3 SDF Download SDF
PubChem ID 3082717 Appearance Powder
Formula C21H25Cl3N2O M.Wt 427.8
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO and to 50 mM in ethanol
Chemical Name 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide;hydrochloride
SMILES CN(C(CN1CCCC1)C2=CC=CC=C2)C(=O)CC3=CC(=C(C=C3)Cl)Cl.Cl
Standard InChIKey VFLWVWZSDBTGQJ-VEIFNGETSA-N
Standard InChI InChI=1S/C21H24Cl2N2O.ClH/c1-24(21(26)14-16-9-10-18(22)19(23)13-16)20(15-25-11-5-6-12-25)17-7-3-2-4-8-17;/h2-4,7-10,13,20H,5-6,11-12,14-15H2,1H3;1H/t20-;/m1./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of ICI 199,441 hydrochloride

DescriptionHighly potent κ agonist, 146-fold more active than U-50488 in vitro.

ICI 199,441 hydrochloride Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

ICI 199,441 hydrochloride Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of ICI 199,441 hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3375 mL 11.6877 mL 23.3754 mL 46.7508 mL 58.4385 mL
5 mM 0.4675 mL 2.3375 mL 4.6751 mL 9.3502 mL 11.6877 mL
10 mM 0.2338 mL 1.1688 mL 2.3375 mL 4.6751 mL 5.8439 mL
50 mM 0.0468 mL 0.2338 mL 0.4675 mL 0.935 mL 1.1688 mL
100 mM 0.0234 mL 0.1169 mL 0.2338 mL 0.4675 mL 0.5844 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on ICI 199,441 hydrochloride

Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]acetamides: a novel series of potent and selective kappa-opioid agonists.[Pubmed:1659636]

J Med Chem. 1991 Nov;34(11):3149-58.

This paper describes the synthesis of a series of N-[2-(1-pyrrolidinyl)ethyl]acetamides 1, variously substituted at the carbon adjacent to the amide nitrogen (C1), and related analogues, together with their biological evaluation as opioid kappa agonists. In the first part of the study, the variants in N-acyl, N-alkyl, and amino functions were explored when the substituent at C1 was 1-methylethyl and the optimum was found to be exemplified by 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-(1-methylethyl)-2- (1-pyrrolidinyl)ethyl]acetamide (13). Subsequently, racemic or chiral amino acids were used to introduce other alkyl and aryl substituents at C1 of the ethyl linking moiety. A series of potent compounds, bearing substituted-aryl groups at C1, were discovered, typified by 2-(3,4-dichloro-phenyl)-N-methyl-N-[(1R,S)-1-(3-aminophenyl)-2-(1- pyrrolidinyl)ethyl]acetamide (48), which was 5-fold more active as the racemate than 13 in vitro and exhibited potent naloxone-reversible analgesic effects (ED50 = 0.04 mg/kg sc) in a mouse abdominal constriction model.

2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid kappa agonists.[Pubmed:1846918]

J Med Chem. 1991 Jan;34(1):181-9.

This paper describes the synthesis of a series of N-[2-(1-pyrrolidinyl)ethyl]acetamides (1), methylated at C1 and/or C2 of the ethyl linking group, and their biological evaluation as opioid kappa agonists. Conformational analysis of corresponding desaryl analogues 2 suggested that only those compounds capable of occupying an energy minimum close to that of the known kappa agonist N-[2-(1-pyrrolidinyl)cyclohexyl] acetamide U-50488 might possess kappa agonist properties. Starting from chiral amino acids, other alkyl and aryl substituents were introduced at C1 of the ethyl-linking moiety, giving compounds capable of adopting the same conformation as U-50488. The most potent of these, 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl] acetamide (8), was 146-fold more active than U-50488 in vitro in the mouse vas deferens model and exhibited potent naloxone-reversible analgesic effects (ED50 = 0.004 mg/kg sc) in an abdominal constriction model.

Keywords:

ICI 199,441 hydrochloride,115199-84-3,Natural Products,Opioid Receptor, buy ICI 199,441 hydrochloride , ICI 199,441 hydrochloride supplier , purchase ICI 199,441 hydrochloride , ICI 199,441 hydrochloride cost , ICI 199,441 hydrochloride manufacturer , order ICI 199,441 hydrochloride , high purity ICI 199,441 hydrochloride

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: