Peptide YY(3-36), PYY, humanY2R agonist CAS# 123583-37-9 |
- VTP-27999 Hydrochloride
Catalog No.:BCC2050
CAS No.:1264191-73-2
- Aliskiren Hemifumarate
Catalog No.:BCC5018
CAS No.:173334-58-2
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 123583-37-9 | SDF | Download SDF |
| PubChem ID | 71581482 | Appearance | Powder |
| Formula | C180H279N53O54 | M.Wt | 4049.6 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 1 mg/ml in sterile water | ||
| Sequence | H2N-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2 | ||
| SMILES | CCC(C)C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)N2CCCC2C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CO)C(=O)N3CCCC3C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC6=CNC=N6)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)N | ||
| Standard InChIKey | AUHJXHCVECGTKR-RIBGVNDISA-N | ||
| Standard InChI | InChI=1S/C180H279N53O54/c1-17-91(12)141(185)171(282)214-114(27-18-19-61-181)175(286)232-67-25-33-130(232)169(280)211-111(53-58-137(247)248)147(258)204-94(15)174(285)231-66-24-32-129(231)168(279)200-82-135(244)205-109(52-57-136(245)246)152(263)226-126(80-140(253)254)157(268)203-93(14)146(257)228-128(84-235)176(287)233-68-26-34-131(233)170(281)212-113(55-60-139(251)252)154(265)210-112(54-59-138(249)250)155(266)216-117(70-87(4)5)159(270)224-124(78-133(183)242)164(275)208-106(29-21-63-197-178(189)190)150(261)220-121(75-98-39-47-103(239)48-40-98)162(273)221-120(74-97-37-45-102(238)46-38-97)156(267)202-92(13)145(256)227-127(83-234)167(278)219-116(69-86(2)3)158(269)207-107(30-22-64-198-179(191)192)151(262)223-123(77-100-81-195-85-201-100)163(274)222-122(76-99-41-49-104(240)50-42-99)161(272)217-118(71-88(6)7)160(271)225-125(79-134(184)243)165(276)218-119(72-89(8)9)166(277)229-142(90(10)11)172(283)230-143(95(16)236)173(284)213-108(31-23-65-199-180(193)194)148(259)209-110(51-56-132(182)241)153(264)206-105(28-20-62-196-177(187)188)149(260)215-115(144(186)255)73-96-35-43-101(237)44-36-96/h35-50,81,85-95,105-131,141-143,234-240H,17-34,51-80,82-84,181,185H2,1-16H3,(H2,182,241)(H2,183,242)(H2,184,243)(H2,186,255)(H,195,201)(H,200,279)(H,202,267)(H,203,268)(H,204,258)(H,205,244)(H,206,264)(H,207,269)(H,208,275)(H,209,259)(H,210,265)(H,211,280)(H,212,281)(H,213,284)(H,214,282)(H,215,260)(H,216,266)(H,217,272)(H,218,276)(H,219,278)(H,220,261)(H,221,273)(H,222,274)(H,223,262)(H,224,270)(H,225,271)(H,226,263)(H,227,256)(H,228,257)(H,229,277)(H,230,283)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t91?,92-,93+,94+,95?,105-,106+,107-,108-,109+,110-,111+,112+,113+,114+,115-,116-,117+,118-,119-,120-,121-,122-,123-,124+,125-,126+,127-,128+,129?,130?,131?,141+,142-,143-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | NPY Y2 receptor agonist. Peripheral administration inhibits food intake in mice. This effect is greater when Peptide YY (3-36) is administered in combination with GLP-1 (7-36) (Cat.No. 2082). |
Peptide YY(3-36), PYY, human Dilution Calculator
Peptide YY(3-36), PYY, human Molarity Calculator
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Peptide YY (PYY) is a short (36-amino acid) peptide released by cells in the ileum and colon in response to feeding. It is also known as peptide tyrosine tyrosine or pancreatic peptide YY3-36. [1]
Studies have shown an important role of PYY (3-36) in the regulation of appetite control. It is the major circulating form of the peptide, is considered to reduce food intake in humans and rodents via high affinity binding to the auto-inhibitory neuropeptide Y receptor Y2R in the hypothalamic arcuate nucleus (ARC), a brain area responsible for the regulation of food intake. PYY (3-36) may represent a promising tool for the treatment of obesity.
PYY exerts its action through NPY receptors; it inhibits gastric motility and increases water and electrolyte absorption in the colon. [2] PYY may also suppress pancreatic secretion. Several studies have shown acute peripheral administration of PYY3-36 inhibits feeding of rodents and primates. Other studies on Y2R-knockout mice have shown no anorectic effect on them. These findings indicate PYY3-36 has an anorectic (losing appetite) effect, which is suggested to be mediated by Y2R. PYY works by slowing the gastric emptying; hence, it increases efficiency of digestion and nutrient absorption after a meal. Research has also indicated PYY may be useful in removing aluminum accumulated in the brain.
Fig 1. Structure of PPY
Ref:
1. Entrez Gene: PYY peptide YY
2. DeGroot, Leslie Jacob (1989). In J. E. McGuigan. Endocrinology. Philadelphia: Saunders. p. 2754.
- rac BHFF
Catalog No.:BCC7644
CAS No.:123557-91-5
- AQ-RA 741
Catalog No.:BCC7314
CAS No.:123548-16-3
- Azelnidipine
Catalog No.:BCC4400
CAS No.:123524-52-7
- Linderaspirone A
Catalog No.:BCN6122
CAS No.:1235126-46-1
- Biperiden HCl
Catalog No.:BCC4565
CAS No.:1235-82-1
- Demethylmurrayanine
Catalog No.:BCN4721
CAS No.:123497-84-7
- 3-O-Caffeoylquinic acid methyl ester
Catalog No.:BCN3484
CAS No.:123483-19-2
- SAR191801
Catalog No.:BCC6393
CAS No.:1234708-04-3
- LY2608204
Catalog No.:BCC4969
CAS No.:1234703-40-2
- PNU 282987
Catalog No.:BCC7318
CAS No.:123464-89-1
- PM 102
Catalog No.:BCC6105
CAS No.:1234564-95-4
- LRRK2-IN-1
Catalog No.:BCC1706
CAS No.:1234480-84-2
- Curcumadionol
Catalog No.:BCN3561
CAS No.:1235984-45-8
- PHP 501 trifluoroacetate
Catalog No.:BCC6193
CAS No.:1236105-75-1
- 740 Y-P
Catalog No.:BCC5861
CAS No.:1236188-16-1
- Clerosterol glucoside
Catalog No.:BCN6123
CAS No.:123621-00-1
- Salviaplebeiaside
Catalog No.:BCN7304
CAS No.:1236273-88-3
- Diosbulbin L
Catalog No.:BCN7305
CAS No.:1236285-87-2
- Tenofovir maleate
Catalog No.:BCC4262
CAS No.:1236287-04-9
- Fmoc-Glu(OBzl)-OH
Catalog No.:BCC3493
CAS No.:123639-61-2
- NS 398
Catalog No.:BCC6857
CAS No.:123653-11-2
- Iguratimod
Catalog No.:BCC1641
CAS No.:123663-49-0
- Pimasertib (AS-703026)
Catalog No.:BCC2529
CAS No.:1236699-92-5
- Trigoxyphin A
Catalog No.:BCN6875
CAS No.:1236874-00-2
Two molecular forms of peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY 1-36 and PYY 3-36.[Pubmed:8059011]
Regul Pept. 1994 May 5;51(2):151-9.
Two endogenous forms of PYY are abundant in man and dog, PYY 1-36 (PYY-I) and PYY 3-36 (PYY-II). PYY-II is a major molecular form of PYY in human colon, but it is not known, whether PYY-II is also released into the circulating blood. Several radioimmunoassays for measuring PYY-I in plasma have been developed, but it has not been reported, whether they equally detect PYY-II. We characterize a radioimmunoassay for measuring PYY in human plasma which equally recognizes PYY-I and PYY-II. Using this radioimmunoassay and reversed phase HPLC we demonstrate the existence of two forms of PYY in human blood, coeluting with synthetic PYY-I and PYY-II.
