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Clerosterol glucoside

CAS# 123621-00-1

Clerosterol glucoside

Catalog No. BCN6123----Order now to get a substantial discount!

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Clerosterol glucoside: 5mg $615 In Stock
Clerosterol glucoside: 10mg Please Inquire In Stock
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Quality Control of Clerosterol glucoside

Number of papers citing our products

Chemical structure

Clerosterol glucoside

3D structure

Chemical Properties of Clerosterol glucoside

Cas No. 123621-00-1 SDF Download SDF
PubChem ID 91895415 Appearance Powder
Formula C35H58O6 M.Wt 574.8
Type of Compound Steroids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2R,3R,4S,5S,6R)-2-[[(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5S)-5-ethyl-6-methylhept-6-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
SMILES CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC5C(C(C(C(O5)CO)O)O)O)C)C)C(=C)C
Standard InChIKey FKZKAGYCKXYXKP-VPFCYKORSA-N
Standard InChI InChI=1S/C35H58O6/c1-7-22(20(2)3)9-8-21(4)26-12-13-27-25-11-10-23-18-24(14-16-34(23,5)28(25)15-17-35(26,27)6)40-33-32(39)31(38)30(37)29(19-36)41-33/h10,21-22,24-33,36-39H,2,7-9,11-19H2,1,3-6H3/t21-,22+,24+,25+,26-,27+,28+,29-,30-,31+,32-,33-,34+,35-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Clerosterol glucoside

The fresh fruits of Momordica charantia L.

Biological Activity of Clerosterol glucoside

DescriptionClerosterol exerts its cytotoxic effect in A2058 human melanoma cells by caspases-dependent apoptosis.

Protocol of Clerosterol glucoside

Cell Research

Cytotoxic Effect of Clerosterol Isolated from Codium fragile on A2058 Human Melanoma Cells.[Reference: WebLink]

Marine Drugs, 2013, 11(2):418-430.


METHODS AND RESULTS:
The cytotoxic effects and mechanism of action of clerosterol(Clerosterol glucoside), isolated from the marine alga Codium fragile, were investigated in A2058 human melanoma cells. Clerosterol inhibited the growth of A2058 cells with an IC50 of 150 µM and induced apoptotic cell death, as evidenced by DNA fragmentation, an increase in the number of sub-G1 hypodiploid cells and the presence of apoptotic bodies. Clerosterol treatment caused the loss of mitochondrial membrane potential. Alterations in the expression of apoptosis-associated proteins in response to clerosterol treatment included upregulation of Bax, downregulation of Bcl-2 and activation of caspases 3 and 9. The pan-caspase inhibitor treatment attenuated the expression of the active form of caspases and cell death induced by clerosterol.
CONCLUSIONS:
The present results show that clerosterol exerts its cytotoxic effect in A2058 human melanoma cells by caspases-dependent apoptosis.

Clerosterol glucoside Dilution Calculator

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Clerosterol glucoside Molarity Calculator

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Preparing Stock Solutions of Clerosterol glucoside

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7397 mL 8.6987 mL 17.3974 mL 34.7947 mL 43.4934 mL
5 mM 0.3479 mL 1.7397 mL 3.4795 mL 6.9589 mL 8.6987 mL
10 mM 0.174 mL 0.8699 mL 1.7397 mL 3.4795 mL 4.3493 mL
50 mM 0.0348 mL 0.174 mL 0.3479 mL 0.6959 mL 0.8699 mL
100 mM 0.0174 mL 0.087 mL 0.174 mL 0.3479 mL 0.4349 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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