PHP 501 trifluoroacetate

Potent GABAA antagonist CAS# 1236105-75-1

PHP 501 trifluoroacetate

Catalog No. BCC6193----Order now to get a substantial discount!

Product Name & Size Price Stock
PHP 501 trifluoroacetate: 5mg $127 In Stock
PHP 501 trifluoroacetate: 10mg Please Inquire In Stock
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Chemical structure

PHP 501 trifluoroacetate

3D structure

Chemical Properties of PHP 501 trifluoroacetate

Cas No. 1236105-75-1 SDF Download SDF
PubChem ID 90488945 Appearance Powder
Formula C22H22F3N3O3 M.Wt 433.42
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO
Chemical Name 4-[1-hydroxy-5-(3-phenylphenyl)pyrazol-4-yl]piperidine;2,2,2-trifluoroacetic acid
SMILES C1CNCCC1C2=C(N(N=C2)O)C3=CC=CC(=C3)C4=CC=CC=C4.C(=O)(C(F)(F)F)O
Standard InChIKey SULXXKLCQRXMHP-UHFFFAOYSA-N
Standard InChI InChI=1S/C20H21N3O.C2HF3O2/c24-23-20(19(14-22-23)16-9-11-21-12-10-16)18-8-4-7-17(13-18)15-5-2-1-3-6-15;3-2(4,5)1(6)7/h1-8,13-14,16,21,24H,9-12H2;(H,6,7)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of PHP 501 trifluoroacetate

DescriptionPotent GABAA antagonist (Ki = 0.0028 μM at rat GABAA receptors; IC50 = 0.024 μM at human α1β2γ2 GABAA-expressing tsA201 cells). Displays no inhibitory activity at hGAT-1, hGAT-2, hGAT-3 or hBGT-1 GABA transporters.

PHP 501 trifluoroacetate Dilution Calculator

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PHP 501 trifluoroacetate Molarity Calculator

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Preparing Stock Solutions of PHP 501 trifluoroacetate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3072 mL 11.5362 mL 23.0723 mL 46.1446 mL 57.6808 mL
5 mM 0.4614 mL 2.3072 mL 4.6145 mL 9.2289 mL 11.5362 mL
10 mM 0.2307 mL 1.1536 mL 2.3072 mL 4.6145 mL 5.7681 mL
50 mM 0.0461 mL 0.2307 mL 0.4614 mL 0.9229 mL 1.1536 mL
100 mM 0.0231 mL 0.1154 mL 0.2307 mL 0.4614 mL 0.5768 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on PHP 501 trifluoroacetate

Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships.[Pubmed:20355712]

J Med Chem. 2010 Apr 22;53(8):3417-21.

A series of substituted 1-hydroxypyrazole analogues of the GABA(A) receptor partial agonist 5-(4-piperidyl)-3-isoxazolol (4-PIOL) have been synthesized and pharmacologically characterized. Several of the analogues displayed K(i) in the low nanomolar range at the native GABA(A) receptors and potent antagonism of the alpha(1)beta(2)gamma(2) receptor. It appears that several regions situated in proximity to the core of the orthosteric binding site of the GABA(A) receptor are able to accommodate large hydrophobic substituents.

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