LY2608204GK activator CAS# 1234703-40-2 |
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| Cas No. | 1234703-40-2 | SDF | Download SDF |
| PubChem ID | 46832368 | Appearance | Powder |
| Formula | C28H37N3O3S3 | M.Wt | 559.81 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 100 mg/mL (178.63 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | (1R,2S)-2-cyclohexyl-1-(4-cyclopropylsulfonylphenyl)-N-[5-(2-pyrrolidin-1-ylethylsulfanyl)-1,3-thiazol-2-yl]cyclopropane-1-carboxamide | ||
| SMILES | C1CCC(CC1)C2CC2(C3=CC=C(C=C3)S(=O)(=O)C4CC4)C(=O)NC5=NC=C(S5)SCCN6CCCC6 | ||
| Standard InChIKey | QIIVJLHCZUTGSD-CUBQBAPOSA-N | ||
| Standard InChI | InChI=1S/C28H37N3O3S3/c32-26(30-27-29-19-25(36-27)35-17-16-31-14-4-5-15-31)28(18-24(28)20-6-2-1-3-7-20)21-8-10-22(11-9-21)37(33,34)23-12-13-23/h8-11,19-20,23-24H,1-7,12-18H2,(H,29,30,32)/t24-,28-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | LY2608204 is an activator of glucokinase (GK) with an EC50 value of 42 nM | |||||
| Targets | GK | |||||
| IC50 | 42 nM(EC50) | |||||
LY2608204 Dilution Calculator
LY2608204 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.7863 mL | 8.9316 mL | 17.8632 mL | 35.7264 mL | 44.658 mL |
| 5 mM | 0.3573 mL | 1.7863 mL | 3.5726 mL | 7.1453 mL | 8.9316 mL |
| 10 mM | 0.1786 mL | 0.8932 mL | 1.7863 mL | 3.5726 mL | 4.4658 mL |
| 50 mM | 0.0357 mL | 0.1786 mL | 0.3573 mL | 0.7145 mL | 0.8932 mL |
| 100 mM | 0.0179 mL | 0.0893 mL | 0.1786 mL | 0.3573 mL | 0.4466 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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LY2608204 is a novel and potent activates of glucokinase (GK) with the EC50 value of 42nM [1].
LY2608204 has shown the novel and potent stimulant of glucokinase (GK) with the EC50 value of 42nM at lower glucose concentrations. In addition, LY2608204 has been reported to activate glucose metabolism with the EC50 value of 579nM in rat insulinoma INS1-E cell lines. Apart from these, LY2608204 has been revealed to lower plasma glucose in a dose-dependent fashion at the levels of fasted and postprandial [1].
References:
[1] KJ Filipski, BD Stevens . Glucokinase activators in development .2012 books
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LY2608204 is a activator of glucokinase (GK) with EC50 of 42 nM.
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