LY2608204

GK activator CAS# 1234703-40-2

LY2608204

Catalog No. BCC4969----Order now to get a substantial discount!

Product Name & Size Price Stock
LY2608204: 5mg $184 In Stock
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Chemical structure

LY2608204

3D structure

Chemical Properties of LY2608204

Cas No. 1234703-40-2 SDF Download SDF
PubChem ID 46832368 Appearance Powder
Formula C28H37N3O3S3 M.Wt 559.81
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : ≥ 100 mg/mL (178.63 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name (1R,2S)-2-cyclohexyl-1-(4-cyclopropylsulfonylphenyl)-N-[5-(2-pyrrolidin-1-ylethylsulfanyl)-1,3-thiazol-2-yl]cyclopropane-1-carboxamide
SMILES C1CCC(CC1)C2CC2(C3=CC=C(C=C3)S(=O)(=O)C4CC4)C(=O)NC5=NC=C(S5)SCCN6CCCC6
Standard InChIKey QIIVJLHCZUTGSD-CUBQBAPOSA-N
Standard InChI InChI=1S/C28H37N3O3S3/c32-26(30-27-29-19-25(36-27)35-17-16-31-14-4-5-15-31)28(18-24(28)20-6-2-1-3-7-20)21-8-10-22(11-9-21)37(33,34)23-12-13-23/h8-11,19-20,23-24H,1-7,12-18H2,(H,29,30,32)/t24-,28-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of LY2608204

DescriptionLY2608204 is an activator of glucokinase (GK) with an EC50 value of 42 nM
TargetsGK    
IC5042 nM(EC50)     

LY2608204 Dilution Calculator

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LY2608204 Molarity Calculator

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Preparing Stock Solutions of LY2608204

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7863 mL 8.9316 mL 17.8632 mL 35.7264 mL 44.658 mL
5 mM 0.3573 mL 1.7863 mL 3.5726 mL 7.1453 mL 8.9316 mL
10 mM 0.1786 mL 0.8932 mL 1.7863 mL 3.5726 mL 4.4658 mL
50 mM 0.0357 mL 0.1786 mL 0.3573 mL 0.7145 mL 0.8932 mL
100 mM 0.0179 mL 0.0893 mL 0.1786 mL 0.3573 mL 0.4466 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on LY2608204

LY2608204 is a novel and potent activates of glucokinase (GK) with the EC50 value of 42nM [1].

LY2608204 has shown the novel and potent stimulant of glucokinase (GK) with the EC50 value of 42nM at lower glucose concentrations. In addition, LY2608204 has been reported to activate glucose metabolism with the EC50 value of 579nM in rat insulinoma INS1-E cell lines. Apart from these, LY2608204 has been revealed to lower plasma glucose in a dose-dependent fashion at the levels of fasted and postprandial [1].

References:
[1] KJ Filipski, BD Stevens . Glucokinase activators in development .2012 books

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Description

LY2608204 is a activator of glucokinase (GK) with EC50 of 42 nM.

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