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Quercetin Dihydrate

PLA2 and PI 3-kinase inhibitor CAS# 6151-25-3

Quercetin Dihydrate

Catalog No. BCN2967----Order now to get a substantial discount!

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Quality Control of Quercetin Dihydrate

Number of papers citing our products

Chemical structure

Quercetin Dihydrate

3D structure

Chemical Properties of Quercetin Dihydrate

Cas No. 6151-25-3 SDF Download SDF
PubChem ID 5284452 Appearance Yellow powder
Formula C15H14O9 M.Wt 338.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Synonyms 3,3',4',5,7-Pentahydroxyflavone dihydrate
Solubility Soluble in DMSO > 10 mM
Chemical Name 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one;dihydrate
SMILES C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O.O.O
Standard InChIKey GMGIWEZSKCNYSW-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H10O7.2H2O/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6;;/h1-5,16-19,21H;2*1H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Quercetin Dihydrate

The flower bud of Sophora flavescens Ait.

Biological Activity of Quercetin Dihydrate

DescriptionQuercetin dihydrate loaded electrospun nanofibrous membrane show antimycotic effect on candida albicans. Clinoptilolite modified with quercetin dihydrate has shown better cytotoxicity compared with clinoptilolite modified with quercetin. The supplementation of quercetin dihydrate and gallate promotes an increase in fecal sterols, which in turn leads to a decreased absorption of dietary cholesterol as well as lower plasma and hepatic cholesterol.
TargetsHMG-CoA Reductase | SOD | Antifection
In vitro

Modified natural clinoptilolite with quercetin and quercetin dihydrate and the study of their anticancer activity[Reference: WebLink]

Microporous and Mesoporous Materials, 2012,147( 1): 59-67.

Natural zeolite of the clinoptilolite type and their modified forms CTQ and CTQD with low content (0.06% and 1%) of Q and QD have been used for the study of their anticancer activity.
METHODS AND RESULTS:
Carcinoma cell lines Jurkat, CEM, HeLa, MCF7, A549 and MDA were treated with various amounts of natural clinoptilolite and their modified forms CTQ and CTQD. The water content of the channel system influences the cytotoxicity of zeolite. The results of the study of pure CT thermally activated at two different temperatures 110 and 400 °C confirmed the better cytotoxicity of CT activated at 110 °C (CT110) with higher content of water in comparison with CT activated at 400 °C (CT400).
CONCLUSIONS:
Clinoptilolite modified with Quercetin Dihydrate (CTQD) has shown better cytotoxicity compared with clinoptilolite modified with quercetin (CTQ).

In vivo

Quercetin dihydrate and gallate supplements lower plasma and hepatic lipids and change activities of hepatic antioxidant enzymes in high cholesterol-fed rats.[Pubmed: 12098884 ]

Int J Vitam Nutr Res. 2002 May;72(3):161-9.

This study was designed to test the lipid-lowering and antioxidant activity of two bioflavonoids, Quercetin Dihydrate and gallate.
METHODS AND RESULTS:
Four groups of rats were given a semisynthetic diet containing 10 g cholesterol/kg for six weeks. The control group received only a high-cholesterol diet, whereas the other three groups received a diet including 1 g lovastatin, 1 g Quercetin Dihydrate, or 1 g gallate/kg. The Quercetin Dihydrate and gallate supplements both significantly lowered the plasma lipid and hepatic cholesterol levels compared to those of the control. The hepatic 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase activity was significantly lowered by the Quercetin Dihydrate when compared to the other groups, while the hepatic acyl CoA: cholesterol acyltransferase (ACAT) activity was only significantly higher in the control group. The overall potential for antioxidant protection was significantly enhanced by the Quercetin Dihydrate and gallate supplements through lowering the plasma and hepatic thiobarbituric acid reactive substances (TBARS) levels and increasing the hepatic superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in high-cholesterol-fed rats.
CONCLUSIONS:
These results suggest that the supplementation of Quercetin Dihydrate and gallate promotes an increase in fecal sterols, which in turn leads to a decreased absorption of dietary cholesterol as well as lower plasma and hepatic cholesterol.

Protocol of Quercetin Dihydrate

Structure Identification
J Biotechnol Biomater 2012, 2(6):248.

Antimycolytic effect of quercetin dihydrate loaded electrospun nanofibrous membrane on Candida albicans[Reference: WebLink]

Candida is an opportunistic fungus, known to cause systemic and life threatening infections in immunosuppressed patients. In our attempt to dealt with this ominous fungal pathogen we have successfully fabricated ultrafine poly (D,L-lactide-coglycolide), PLGA, nanofibrous membrane loaded with different concentrations of Quercetin Dihydrate, natural flavones with antioxidant and antimycolytic activity, using acetone-dichloromethane as solvent system.
CONCLUSIONS:
The bulk fabrication of these nanofibrous membrane was performed via electrospinning technique. The morphology of resulting nanofibrous membrane with or without Quercetin Dihydrate was examined using field emission scanning electron microscopy (FE-SEM). The nanofibrous membrane was also subjected to detailed analysis by Fourier transform infrared spectrometry (FTIR). The antimycolytic effect of these Quercetin Dihydrate loaded nanofibrous membrane on to the viability of C. albicans cells was established using modified XTT (2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide) reduction assay in 6 well polystyrene microtiter plates.

Quercetin Dihydrate Dilution Calculator

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Quercetin Dihydrate Molarity Calculator

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Preparing Stock Solutions of Quercetin Dihydrate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.956 mL 14.7798 mL 29.5596 mL 59.1191 mL 73.8989 mL
5 mM 0.5912 mL 2.956 mL 5.9119 mL 11.8238 mL 14.7798 mL
10 mM 0.2956 mL 1.478 mL 2.956 mL 5.9119 mL 7.3899 mL
50 mM 0.0591 mL 0.2956 mL 0.5912 mL 1.1824 mL 1.478 mL
100 mM 0.0296 mL 0.1478 mL 0.2956 mL 0.5912 mL 0.739 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Quercetin Dihydrate

Quercetin Dihydrate is the dihydrate preparation of Quercetin, a ubiquitous natural flavonoid with antiproliferative properties. Quercetin is described to inhibit PLA2 and PI 3-kinase (IC50 = 3.8 microM), blocking the ATP binding site of this kinase and i

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References on Quercetin Dihydrate

Quercetin dihydrate and gallate supplements lower plasma and hepatic lipids and change activities of hepatic antioxidant enzymes in high cholesterol-fed rats.[Pubmed:12098884]

Int J Vitam Nutr Res. 2002 May;72(3):161-9.

This study was designed to test the lipid-lowering and antioxidant activity of two bioflavonoids, Quercetin Dihydrate and gallate. Four groups of rats were given a semisynthetic diet containing 10 g cholesterol/kg for six weeks. The control group received only a high-cholesterol diet, whereas the other three groups received a diet including 1 g lovastatin, 1 g Quercetin Dihydrate, or 1 g gallate/kg. The Quercetin Dihydrate and gallate supplements both significantly lowered the plasma lipid and hepatic cholesterol levels compared to those of the control. The hepatic 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase activity was significantly lowered by the Quercetin Dihydrate when compared to the other groups, while the hepatic acyl CoA: cholesterol acyltransferase (ACAT) activity was only significantly higher in the control group. The overall potential for antioxidant protection was significantly enhanced by the Quercetin Dihydrate and gallate supplements through lowering the plasma and hepatic thiobarbituric acid reactive substances (TBARS) levels and increasing the hepatic superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in high-cholesterol-fed rats. These results suggest that the supplementation of Quercetin Dihydrate and gallate promotes an increase in fecal sterols, which in turn leads to a decreased absorption of dietary cholesterol as well as lower plasma and hepatic cholesterol.

Description

Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

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