IPI-145 (INK1197)PI3K-δ/PI3K-γ inhibitor CAS# 1201438-56-3 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 1201438-56-3 | SDF | Download SDF |
| PubChem ID | 50905713 | Appearance | Powder |
| Formula | C22H17ClN6O | M.Wt | 416.86 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | IPI-145; INK1197 | ||
| Solubility | Soluble in DMSO > 10 mM | ||
| Chemical Name | 8-chloro-2-phenyl-3-[(1S)-1-(7H-purin-6-ylamino)ethyl]isoquinolin-1-one | ||
| SMILES | CC(C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5 | ||
| Standard InChIKey | SJVQHLPISAIATJ-ZDUSSCGKSA-N | ||
| Standard InChI | InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | IPI-145 is an orally bioavailable and highly selective inhibitor of PI3K-δ and PI3K-γ with IC50 values of 0.36 nM and 19.6 nM, respectively. | |||||
| Targets | PI3K-δ | PI3K-γ | ||||
| IC50 | 0.36 nM | 19.6 nM | ||||
IPI-145 (INK1197) Dilution Calculator
IPI-145 (INK1197) Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3989 mL | 11.9944 mL | 23.9889 mL | 47.9777 mL | 59.9722 mL |
| 5 mM | 0.4798 mL | 2.3989 mL | 4.7978 mL | 9.5955 mL | 11.9944 mL |
| 10 mM | 0.2399 mL | 1.1994 mL | 2.3989 mL | 4.7978 mL | 5.9972 mL |
| 50 mM | 0.048 mL | 0.2399 mL | 0.4798 mL | 0.9596 mL | 1.1994 mL |
| 100 mM | 0.024 mL | 0.1199 mL | 0.2399 mL | 0.4798 mL | 0.5997 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
IPI-145 (also known as INK1197), an isoquinolinone derivative, is a small-molecule phosphoinositide-3 kinases (PI3K) inhibitor that selectively and potently inhibits two PI3K isoforms, PI3K-δ and PI3K-γ, with half maximal inhibition concentration IC50 of 2.5 nM and 27 nM respectively. Despite of preference for PI3K-δ and PI3K-γ, IPI-145 also inhibits other PI3K isoforms, PI3K-α and PI3K-β, to a lesser extent with IC50 of 1602 nM and 85 nM respectively.
Due to the essential role of PI3K-δ in the proliferation of B cell and T cell, IPI-145 exhibits potent anti-proliferative activity against both cells with IC50 of 0.5 nM and 9.5 nM respectively leading to inhibition of neutrophil migration and basophil activation.
Inhibition of immune function through IPI-145-induced PI3K-δ and PI3K-γ blockade potentiates its application in the treatment of multiple inflammatory, autoimmune and hematologic diseases.
References:
[1] Winkler DG1, Faia KL, DiNitto JP, Ali JA, White KF, Brophy EE, Pink MM, Proctor JL, Lussier J, Martin CM, Hoyt JG, Tillotson B, Murphy EL, Lim AR, Thomas BD, Macdougall JR, Ren P, Liu Y, Li LS, Jessen KA, Fritz CC, Dunbar JL, Porter JR, Rommel C, Palombella VJ, Changelian PS, Kutok JL. PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models. Chem Biol. 2013 Nov 21;20(11):1364-74. doi: 10.1016/j.chembiol.2013.09.017. Epub 2013 Nov 7.
- Flavanthrin
Catalog No.:BCN3687
CAS No.:120090-80-4
- Fmoc-D-Arg(Mtr)-OH
Catalog No.:BCC3078
CAS No.:120075-24-3
- CRF (6-33)
Catalog No.:BCC5791
CAS No.:120066-38-8
- Shizukanolide F
Catalog No.:BCN6411
CAS No.:120061-96-3
- Meridinol
Catalog No.:BCN6087
CAS No.:120051-54-9
- Edgeworin
Catalog No.:BCN6561
CAS No.:120028-43-5
- VCH-916
Catalog No.:BCC2031
CAS No.:1200133-34-1
- Donepezil HCl
Catalog No.:BCC4569
CAS No.:120011-70-3
- Dichlorphenamide
Catalog No.:BCC3761
CAS No.:120-97-8
- 1,2-Benzenediol
Catalog No.:BCN6103
CAS No.:120-80-9
- N,N'-Bis(salicylidene)-1,3-propanediamine
Catalog No.:BCC9063
CAS No.:120-70-7
- 2'-Methylacetanilide
Catalog No.:BCC8581
CAS No.:120-66-1
- Crotaleschenine
Catalog No.:BCN2077
CAS No.:120154-95-2
- Vinflunine Tartrate
Catalog No.:BCC4602
CAS No.:1201898-17-0
- MLN9708
Catalog No.:BCC2091
CAS No.:1201902-80-8
- TCS 2210
Catalog No.:BCC7798
CAS No.:1201916-31-5
- Cynoglossamine
Catalog No.:BCN1970
CAS No.:120193-39-7
- 3,4-Dihydroxycinnamamide
Catalog No.:BCN6090
CAS No.:1202-41-1
- Clopidogrel
Catalog No.:BCC2497
CAS No.:120202-66-6
- Clopidogrel Related Compound C
Catalog No.:BCN2689
CAS No.:120202-71-3
- NMS-P715
Catalog No.:BCC6373
CAS No.:1202055-34-2
- Tenidap
Catalog No.:BCC7419
CAS No.:120210-48-2
- 1beta-Hydroxyeuscaphic acid
Catalog No.:BCN3517
CAS No.:120211-98-5
- CGS 21680
Catalog No.:BCC1475
CAS No.:120225-54-9
